WO1999024553A8 - X-ray crystal comprising hiv-1 gp120 - Google Patents

X-ray crystal comprising hiv-1 gp120

Info

Publication number
WO1999024553A8
WO1999024553A8 PCT/US1998/023905 US9823905W WO9924553A8 WO 1999024553 A8 WO1999024553 A8 WO 1999024553A8 US 9823905 W US9823905 W US 9823905W WO 9924553 A8 WO9924553 A8 WO 9924553A8
Authority
WO
WIPO (PCT)
Prior art keywords
subject invention
provides
interaction
crystal
hiv
Prior art date
Application number
PCT/US1998/023905
Other languages
French (fr)
Other versions
WO1999024553A9 (en
WO1999024553A3 (en
WO1999024553A2 (en
Inventor
Peter D Kwong
Wayne A Hendrickson
Joseph G Sodroski
Richard T Wyatt
Original Assignee
Univ Columbia
Dana Farber Cancer Inst Inc
Peter D Kwong
Wayne A Hendrickson
Joseph G Sodroski
Richard T Wyatt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Dana Farber Cancer Inst Inc, Peter D Kwong, Wayne A Hendrickson, Joseph G Sodroski, Richard T Wyatt filed Critical Univ Columbia
Priority to AU15211/99A priority Critical patent/AU1521199A/en
Priority to EP98959406A priority patent/EP1037963A4/en
Publication of WO1999024553A2 publication Critical patent/WO1999024553A2/en
Publication of WO1999024553A8 publication Critical patent/WO1999024553A8/en
Publication of WO1999024553A9 publication Critical patent/WO1999024553A9/en
Publication of WO1999024553A3 publication Critical patent/WO1999024553A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/207—Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The subject invention provides a crystal suitable for X-ray diffraction comprising a polypeptide having an amino acid sequence of a portion of a Human Immunodeficiency Virus envelope glycoprotein gp120. The subject invention also provides the above-described crystals, wherein the crystal is arranged in a space group P2221, so as to form a unit cell of dimensions a=71.6 Å, b=88.1 Å, c=196.7 Å, and which effectively diffracts X-rays for determination of the atomic coordinates of the gp120 to a resolution of 2.5 Å or better. The subject invention additionally provides compounds inhibiting the CD4-gp 120 interaction, compounds inhibiting chemokine receptor-gp120 interaction, mimics of CD4, gp120 variants and uses thereof.
PCT/US1998/023905 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120 WO1999024553A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU15211/99A AU1521199A (en) 1997-11-10 1998-11-10 Crystal comprising human immunodeficiency virus envelope glycoprotein gp120, compounds inhibiting cd4-gp120 interaction, compounds inhibiting chemokine receptor-gp120 interaction, mimics of cd4 and gp120 variants
EP98959406A EP1037963A4 (en) 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US96698797A 1997-11-10 1997-11-10
US96714897A 1997-11-10 1997-11-10
US96740397A 1997-11-10 1997-11-10
US96693297A 1997-11-10 1997-11-10
US08/966,987 1997-11-10
US08/967,148 1997-11-10
US08/967,403 1997-11-10
US08/966,932 1997-11-10
US97674197A 1997-11-24 1997-11-24
US08/976,741 1997-11-24
US8958198P 1998-06-17 1998-06-17
US8958098P 1998-06-17 1998-06-17
US60/089,581 1998-06-17
US60/089,580 1998-06-17
US10063198A 1998-06-18 1998-06-18
US10052998A 1998-06-18 1998-06-18
US10076298A 1998-06-18 1998-06-18
US10076398A 1998-06-18 1998-06-18
US10052198A 1998-06-18 1998-06-18
US09/100,631 1998-06-18
US09/100,763 1998-06-18
US09/100,762 1998-06-18
US09/100,529 1998-06-18
US09/100,521 1998-06-18

Publications (4)

Publication Number Publication Date
WO1999024553A2 WO1999024553A2 (en) 1999-05-20
WO1999024553A8 true WO1999024553A8 (en) 1999-07-22
WO1999024553A9 WO1999024553A9 (en) 2001-05-31
WO1999024553A3 WO1999024553A3 (en) 2003-12-11

Family

ID=27583731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023905 WO1999024553A2 (en) 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120

Country Status (2)

Country Link
EP (1) EP1037963A4 (en)
WO (1) WO1999024553A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US20030125518A1 (en) * 2001-12-01 2003-07-03 Crevecoeur Harry F. Surface simulation synthetic peptides useful in the treatment of hyper-variable viral pathogens
EP1940867A2 (en) 2005-09-06 2008-07-09 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Hiv gp120 crystal structure and its use to identify immunogens
US20130101617A1 (en) * 2010-06-30 2013-04-25 Torrey Pines Institute For Molecular Studies Env trimer immunogens
CN114609392A (en) * 2022-03-08 2022-06-10 武汉科技大学 Screening method and application of HIV (human immunodeficiency virus) fully-humanized broad-spectrum neutralizing antibody

Also Published As

Publication number Publication date
WO1999024553A9 (en) 2001-05-31
WO1999024553A3 (en) 2003-12-11
WO1999024553A2 (en) 1999-05-20
EP1037963A4 (en) 2004-09-22
EP1037963A1 (en) 2000-09-27

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