JP2025065142A5 - - Google Patents
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- JP2025065142A5 JP2025065142A5 JP2025004349A JP2025004349A JP2025065142A5 JP 2025065142 A5 JP2025065142 A5 JP 2025065142A5 JP 2025004349 A JP2025004349 A JP 2025004349A JP 2025004349 A JP2025004349 A JP 2025004349A JP 2025065142 A5 JP2025065142 A5 JP 2025065142A5
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425398P | 2016-11-22 | 2016-11-22 | |
| US62/425,398 | 2016-11-22 | ||
| US201762543696P | 2017-08-10 | 2017-08-10 | |
| US62/543,696 | 2017-08-10 | ||
| PCT/US2017/063048 WO2018098306A1 (en) | 2016-11-22 | 2017-11-22 | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| JP2019547605A JP7778468B2 (ja) | 2016-11-22 | 2017-11-22 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
| JP2023012793A JP2023059873A (ja) | 2016-11-22 | 2023-01-31 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023012793A Division JP2023059873A (ja) | 2016-11-22 | 2023-01-31 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025065142A JP2025065142A (ja) | 2025-04-17 |
| JP2025065142A5 true JP2025065142A5 (enExample) | 2025-05-09 |
Family
ID=62193475
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547605A Active JP7778468B2 (ja) | 2016-11-22 | 2017-11-22 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
| JP2023012793A Pending JP2023059873A (ja) | 2016-11-22 | 2023-01-31 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
| JP2025004349A Pending JP2025065142A (ja) | 2016-11-22 | 2025-01-10 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547605A Active JP7778468B2 (ja) | 2016-11-22 | 2017-11-22 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
| JP2023012793A Pending JP2023059873A (ja) | 2016-11-22 | 2023-01-31 | T細胞悪性腫瘍の免疫療法のためのcd7発現およびキメラ抗原受容体の遮断 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US11440958B2 (enExample) |
| EP (1) | EP3545082A4 (enExample) |
| JP (3) | JP7778468B2 (enExample) |
| KR (2) | KR20190085528A (enExample) |
| CN (3) | CN118581046A (enExample) |
| AU (3) | AU2017363278B2 (enExample) |
| CA (1) | CA3043752A1 (enExample) |
| SG (2) | SG10201912387PA (enExample) |
| WO (1) | WO2018098306A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016017429B1 (pt) | 2014-01-31 | 2022-10-04 | Monolith Materials, Inc | Maçarico de plasma |
| US11987712B2 (en) | 2015-02-03 | 2024-05-21 | Monolith Materials, Inc. | Carbon black generating system |
| CN113713091A (zh) | 2015-02-06 | 2021-11-30 | 新加坡国立大学 | 工程免疫细胞及其用途和生产方法 |
| CA3032246C (en) | 2015-07-29 | 2023-12-12 | Monolith Materials, Inc. | Dc plasma torch electrical power design method and apparatus |
| WO2017027385A1 (en) | 2015-08-07 | 2017-02-16 | Monolith Materials, Inc. | Method of making carbon black |
| US20170066923A1 (en) | 2015-09-09 | 2017-03-09 | Monolith Materials, Inc. | Circular few layer graphene |
| WO2018027036A1 (en) | 2016-08-03 | 2018-02-08 | Dipersio John F | Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors |
| CN118581046A (zh) | 2016-11-22 | 2024-09-03 | 新加坡国立大学 | 用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体 |
| EP3641768B1 (en) | 2017-06-21 | 2025-12-31 | iCell Gene Therapeutics LLC | Chimeric Antigen Receptors (CARs), Compositions and Associated Methods |
| US11648269B2 (en) | 2017-08-10 | 2023-05-16 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof |
| SG11202010996QA (en) | 2018-05-23 | 2020-12-30 | Nat Univ Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| US12227776B2 (en) | 2018-06-13 | 2025-02-18 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US10227576B1 (en) | 2018-06-13 | 2019-03-12 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| CN112292448B (zh) * | 2018-10-31 | 2025-01-10 | 南克维斯特公司 | 表达cd19-car的nk细胞消除cd19阳性淋巴系统恶性肿瘤 |
| KR20210125978A (ko) | 2018-11-01 | 2021-10-19 | 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 | T 세포 조작을 위한 조성물 및 방법 |
| WO2020102589A1 (en) | 2018-11-14 | 2020-05-22 | Medisix Therapeutics Pte Ltd. | Two-gene vectors for generating car-t cells and uses thereof |
| CN109652379B (zh) * | 2018-12-29 | 2022-08-16 | 博生吉医药科技(苏州)有限公司 | Cd7嵌合抗原受体修饰的nk-92mi细胞及其应用 |
| CN113784732B (zh) | 2019-05-07 | 2024-03-22 | 亘喜生物科技(上海)有限公司 | 靶向bcma的工程化免疫细胞及其用途 |
| GB201914611D0 (en) * | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
| CN114746126A (zh) * | 2019-10-11 | 2022-07-12 | 小利兰·斯坦福大学理事会 | 用于可调节细胞定位的重组多肽 |
| CN114729315B (zh) * | 2019-11-20 | 2025-07-22 | 卡瑟里克斯私人有限公司 | 用于提供具有增强功能的免疫细胞的方法 |
| AU2020397189A1 (en) * | 2019-12-05 | 2022-07-14 | Vycellix, Inc. | Modulators of the immune escape mechanism for universal cell therapy |
| US20230019849A1 (en) * | 2019-12-09 | 2023-01-19 | St. Jude Children's Research Hospital, Inc. | Method for Preparing CD7-Negative, CD3-Positive T Cells |
| US12312407B2 (en) * | 2020-01-30 | 2025-05-27 | St Phi Therapeutics Co., Ltd. | Universal T cells and the method of use thereof |
| CN114525259B (zh) * | 2020-11-03 | 2025-02-14 | 南京北恒生物科技有限公司 | 靶向cd7的嵌合抗原受体及其用途 |
| CN112300282A (zh) * | 2020-11-03 | 2021-02-02 | 南京北恒生物科技有限公司 | 靶向cd7的人源化抗体及其用途 |
| CA3201499A1 (en) | 2020-11-13 | 2022-05-19 | Catamaran Bio, Inc. | Genetically modified natural killer cells and methods of use thereof |
| CN114525306B (zh) * | 2020-11-23 | 2025-01-28 | 博生吉医药科技(苏州)有限公司 | 一种cd7-car-t细胞的制备方法及应用 |
| EP4251209A1 (en) | 2020-11-24 | 2023-10-04 | Novartis AG | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| CN115786271B (zh) * | 2021-01-12 | 2025-07-22 | 上海雅科生物科技有限公司 | 靶向cd7的工程化免疫细胞、嵌合抗原受体、cd7阻断分子及应用 |
| EP4303233A4 (en) * | 2021-02-01 | 2025-05-07 | St Phi Therapeutics Co., Ltd. | Targeted protein degradation system and use thereof |
| CN114853900A (zh) * | 2021-02-03 | 2022-08-05 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| CN115044617B (zh) * | 2021-03-08 | 2024-08-13 | 河北森朗生物科技有限公司 | Car t细胞的制备方法、car t细胞及其应用 |
| CN112980800A (zh) * | 2021-03-08 | 2021-06-18 | 河北森朗生物科技有限公司 | Car-t细胞、其构建方法及其应用 |
| CN112662631B (zh) * | 2021-03-16 | 2021-06-29 | 合源生物科技(天津)有限公司 | 一种car-t细胞灌流培养方法 |
| JP2024514942A (ja) | 2021-04-22 | 2024-04-03 | ベイラー カレッジ オブ メディスン | 殺夾雑活性を低下させた免疫細胞を工学的に作製する方法 |
| US20250222026A1 (en) * | 2021-06-08 | 2025-07-10 | Beijing Meikang Geno-Immune Biotechnology Co., Ltd. | Cd7-based humanized chimeric antigen receptor and use thereof |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| US20250161358A1 (en) * | 2022-02-17 | 2025-05-22 | Utc Therapeutics (Shanghai) Co., Ltd. | Modified immune effector cells and uses thereof |
| CN114560943B (zh) * | 2022-02-28 | 2022-12-16 | 先进生物(苏州)有限公司 | Cd7-car-t细胞及其制备方法和应用 |
| US20250099504A1 (en) * | 2022-03-29 | 2025-03-27 | Institute Of Hematology And Blood Diseases Hospital , Chinese Academy Of Medical Sciences | Antibody that specifically binds to cd7 and use thereof in preparing chimeric antigen receptor |
| CN117004603A (zh) * | 2022-04-28 | 2023-11-07 | 南京北恒生物科技有限公司 | 一种cd7基因被敲除的工程化免疫细胞及其用途 |
| IL316653A (en) | 2022-05-20 | 2024-12-01 | Novartis Ag | Antibody drug conjugates |
| US20250387504A1 (en) | 2022-05-20 | 2025-12-25 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN116179495B (zh) * | 2022-11-28 | 2025-06-06 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| WO2024243340A1 (en) | 2023-05-23 | 2024-11-28 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| CN121666232A (zh) | 2023-05-31 | 2026-03-13 | 开普斯坦治疗公司 | 脂质纳米颗粒制剂和组合物 |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025111431A1 (en) | 2023-11-22 | 2025-05-30 | Les Laboratoires Servier | Anti-cd7 antibody-drug conjugates and methods of use thereof |
| EP4559937A1 (en) * | 2023-11-24 | 2025-05-28 | Universitat de Barcelona | Cd7 targeting moieties for the treatment of cd7 positive cancer |
| WO2025179294A2 (en) | 2024-02-22 | 2025-08-28 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2018248A1 (en) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| EP1015616A2 (en) | 1997-09-19 | 2000-07-05 | Dana Farber Cancer Institute, Inc. | Intrabody-mediated control of immune reactions |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| AU2002220265A1 (en) * | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| WO2003051926A2 (en) * | 2001-12-14 | 2003-06-26 | Friedrich-Alexander-Universitaet Erlangen-Nuernberg | Anti-cd7 immunotoxin as fusion protein |
| WO2005017163A2 (en) | 2003-08-15 | 2005-02-24 | Imperial College Innovations Limited | Phenotypic knockout of cell-surface proteins |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20130266551A1 (en) | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| DK2287195T3 (da) | 2004-07-01 | 2019-08-19 | Innate Pharma | Pan-kir2dl nk-receptor-antistoffer og anvendelse heraf i diagnostik og terapi |
| AU2005299353A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Use of modulators of EphA2 and EphrinA1 for the treatment and prevention of infections |
| US20070036773A1 (en) | 2005-08-09 | 2007-02-15 | City Of Hope | Generation and application of universal T cells for B-ALL |
| US7973136B2 (en) | 2005-10-06 | 2011-07-05 | Xencor, Inc. | Optimized anti-CD30 antibodies |
| MX338151B (es) | 2007-03-01 | 2016-04-05 | Symphogen As | Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico. |
| ES2424745T3 (es) | 2007-09-07 | 2013-10-08 | Agensys, Inc. | Anticuerpos y moléculas relacionadas que se unen a las proteínas 24P4C12 |
| CN101952317B (zh) | 2008-01-24 | 2015-07-22 | 诺沃-诺迪斯克有限公司 | 人化抗-人nkg2a单克隆抗体 |
| US8580714B2 (en) | 2009-10-14 | 2013-11-12 | Janssen Biotech, Inc. | Methods of affinity maturing antibodies |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| MX2014010183A (es) | 2012-02-22 | 2015-03-20 | Univ Pennsylvania | Composiciones y metodos para generar una poblacion persistente de celulas t utiles para el tratamiento de cancer. |
| PL4289948T3 (pl) | 2012-05-25 | 2025-06-02 | The Regents Of The University Of California | Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji |
| AU2013329186B2 (en) | 2012-10-10 | 2019-02-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| WO2014093831A2 (en) * | 2012-12-14 | 2014-06-19 | Thomson Reuters (Markets) Llc | Dynamic function builder |
| KR101521224B1 (ko) * | 2012-12-20 | 2015-05-19 | 한양대학교 산학협력단 | T 세포 특이적인 인간화 단일조각항체 전달체 |
| SG11201502792TA (en) | 2012-12-27 | 2015-05-28 | Aduro Biotech Inc | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
| NZ711807A (en) | 2013-02-06 | 2020-06-26 | Celgene Corp | Modified t lymphocytes having improved specificity |
| EP2961831B1 (en) | 2013-02-26 | 2020-06-10 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| PL2997141T3 (pl) | 2013-05-13 | 2023-02-06 | Cellectis | Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| SG11201602979RA (en) | 2013-10-17 | 2016-05-30 | Univ Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
| SG11201603484PA (en) | 2013-11-21 | 2016-05-30 | Ucl Business Plc | Cell |
| US10836998B2 (en) | 2014-02-14 | 2020-11-17 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| CA2943008C (en) | 2014-03-19 | 2021-03-30 | Cellectis | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| WO2016011210A2 (en) | 2014-07-15 | 2016-01-21 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| MX2017004603A (es) | 2014-10-07 | 2017-06-30 | Cellectis | Metodo para modular actividad de celulas inmunes inducidas por car. |
| PT3560953T (pt) | 2014-12-24 | 2024-03-26 | Autolus Ltd | Célula |
| CN113713091A (zh) | 2015-02-06 | 2021-11-30 | 新加坡国立大学 | 工程免疫细胞及其用途和生产方法 |
| KR102632082B1 (ko) * | 2015-02-27 | 2024-02-02 | 아이셀 진 테라퓨틱스 엘엘씨 | 혈액 악성종양을 표적으로 하는 키메라 항원 수용체(car), 조성물 및 이의 용도 |
| AU2016228080B2 (en) | 2015-03-02 | 2020-11-12 | Innovative Cellular Therapeutics Holdings, Ltd. | Reducing immune tolerance induced by PD-L1 |
| GB201507104D0 (en) | 2015-04-27 | 2015-06-10 | Ucl Business Plc | Nucleic acid construct |
| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| WO2017112877A1 (en) * | 2015-12-22 | 2017-06-29 | Icell Gene Therapeutics, Llc | Chimeric antigen receptors and enhancement of anti-tumor activity |
| WO2017149515A1 (en) | 2016-03-04 | 2017-09-08 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| US11390658B2 (en) | 2016-06-06 | 2022-07-19 | St. Jude Children's Research Hospital | Anti-CD7 chimeric antigen receptor and method of use thereof |
| CA2937157A1 (en) | 2016-07-25 | 2018-01-25 | Ucl Business Ltd | Protein-based t-cell receptor knockdown |
| WO2018027036A1 (en) * | 2016-08-03 | 2018-02-08 | Dipersio John F | Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors |
| CN118581046A (zh) | 2016-11-22 | 2024-09-03 | 新加坡国立大学 | 用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体 |
| US11648269B2 (en) | 2017-08-10 | 2023-05-16 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof |
| WO2020102589A1 (en) | 2018-11-14 | 2020-05-22 | Medisix Therapeutics Pte Ltd. | Two-gene vectors for generating car-t cells and uses thereof |
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2017
- 2017-11-22 CN CN202410674061.XA patent/CN118581046A/zh active Pending
- 2017-11-22 SG SG10201912387PA patent/SG10201912387PA/en unknown
- 2017-11-22 CN CN201780073071.6A patent/CN110268049B/zh active Active
- 2017-11-22 CN CN202410674086.XA patent/CN118562882B/zh active Active
- 2017-11-22 EP EP17874643.4A patent/EP3545082A4/en active Pending
- 2017-11-22 JP JP2019547605A patent/JP7778468B2/ja active Active
- 2017-11-22 SG SG11201903830TA patent/SG11201903830TA/en unknown
- 2017-11-22 WO PCT/US2017/063048 patent/WO2018098306A1/en not_active Ceased
- 2017-11-22 US US15/821,153 patent/US11440958B2/en active Active
- 2017-11-22 AU AU2017363278A patent/AU2017363278B2/en active Active
- 2017-11-22 KR KR1020197016703A patent/KR20190085528A/ko not_active Ceased
- 2017-11-22 KR KR1020247020607A patent/KR102889007B1/ko active Active
- 2017-11-22 CA CA3043752A patent/CA3043752A1/en active Pending
- 2017-11-22 US US15/821,170 patent/US10550183B2/en active Active
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2022
- 2022-07-14 US US17/865,292 patent/US11945865B2/en active Active
- 2022-11-10 AU AU2022268355A patent/AU2022268355B2/en active Active
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2023
- 2023-01-31 JP JP2023012793A patent/JP2023059873A/ja active Pending
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2024
- 2024-02-21 US US18/583,551 patent/US20240182567A1/en active Pending
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2025
- 2025-01-10 JP JP2025004349A patent/JP2025065142A/ja active Pending
- 2025-07-04 AU AU2025205147A patent/AU2025205147B2/en active Active