JP2017527275A5 - - Google Patents
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- JP2017527275A5 JP2017527275A5 JP2017504173A JP2017504173A JP2017527275A5 JP 2017527275 A5 JP2017527275 A5 JP 2017527275A5 JP 2017504173 A JP2017504173 A JP 2017504173A JP 2017504173 A JP2017504173 A JP 2017504173A JP 2017527275 A5 JP2017527275 A5 JP 2017527275A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- car
- ror1
- ntrkr1
- antigen receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 17
- 210000002865 immune cell Anatomy 0.000 claims description 12
- 108020001756 ligand binding domains Proteins 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 47
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 43
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 43
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 4
- 210000004896 polypeptide structure Anatomy 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 3
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 3
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000034951 Genetic Translocation Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 102000009490 IgG Receptors Human genes 0.000 description 2
- 108010073807 IgG Receptors Proteins 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 108010087819 Fc receptors Proteins 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470465 | 2014-07-29 | ||
| DKPA201470465 | 2014-07-29 | ||
| PCT/EP2015/067444 WO2016016344A1 (en) | 2014-07-29 | 2015-07-29 | Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527275A JP2017527275A (ja) | 2017-09-21 |
| JP2017527275A5 true JP2017527275A5 (enExample) | 2019-05-30 |
| JP6721568B2 JP6721568B2 (ja) | 2020-07-15 |
Family
ID=51300484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504173A Active JP6721568B2 (ja) | 2014-07-29 | 2015-07-29 | がん免疫療法のためのｒｏｒ１（ｎｔｒｋｒ１）特異的キメラ抗原レセプター |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10752684B2 (enExample) |
| EP (2) | EP3174557B1 (enExample) |
| JP (1) | JP6721568B2 (enExample) |
| KR (1) | KR102048855B1 (enExample) |
| CN (1) | CN106922148B (enExample) |
| AU (1) | AU2015295349B2 (enExample) |
| BR (1) | BR112017001821A2 (enExample) |
| CA (1) | CA2950381C (enExample) |
| DK (2) | DK3174557T3 (enExample) |
| EA (1) | EA034081B1 (enExample) |
| ES (2) | ES2876925T3 (enExample) |
| IL (1) | IL250161B (enExample) |
| MX (1) | MX367787B (enExample) |
| WO (1) | WO2016016344A1 (enExample) |
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| DK2368914T3 (en) | 2006-03-10 | 2019-03-04 | Wyeth Llc | Anti-5T4 antibodies and uses thereof |
| BRPI1013177A2 (pt) * | 2009-05-28 | 2016-04-12 | Glaxo Group Ltd | construto de ligação de antígeno, polipeptídeo isolado, e, método para tratar doença cardíaca |
| US9163258B2 (en) * | 2010-07-23 | 2015-10-20 | Fred Hutchinson Cancer Research Center | Method for the treatment of obesity |
| WO2012136231A1 (en) * | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP3604339B1 (en) * | 2011-01-14 | 2021-03-10 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| CA3111953C (en) | 2011-04-05 | 2023-10-24 | Cellectis | Method for the generation of compact tale-nucleases and uses thereof |
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| WO2013044225A1 (en) * | 2011-09-22 | 2013-03-28 | The Trustees Of The University Of Pennsylvania | A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens |
| ES2654060T3 (es) * | 2011-10-20 | 2018-02-12 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Receptores de antígenos quiméricos anti-CD22 |
| US9272002B2 (en) * | 2011-10-28 | 2016-03-01 | The Trustees Of The University Of Pennsylvania | Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting |
| CA2861491C (en) | 2012-02-13 | 2020-08-25 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| RU2766608C2 (ru) * | 2012-04-11 | 2022-03-15 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| BR112014029417B1 (pt) | 2012-05-25 | 2023-03-07 | Cellectis | Método ex vivo para a preparação de células t para imunoterapia |
| BR122020002986A8 (pt) | 2012-08-20 | 2023-04-18 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapia celular |
| ES2702315T3 (es) * | 2012-08-24 | 2019-02-28 | Univ California | Anticuerpos y vacunas para su uso en tratar cánceres ROR1 e inhibir metástasis |
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| WO2014055657A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
-
2015
- 2015-07-29 WO PCT/EP2015/067444 patent/WO2016016344A1/en not_active Ceased
- 2015-07-29 DK DK15744216.1T patent/DK3174557T3/en active
- 2015-07-29 ES ES18199948T patent/ES2876925T3/es active Active
- 2015-07-29 MX MX2017001211A patent/MX367787B/es active IP Right Grant
- 2015-07-29 US US15/329,932 patent/US10752684B2/en active Active
- 2015-07-29 DK DK18199948.3T patent/DK3453406T3/da active
- 2015-07-29 ES ES15744216T patent/ES2715413T3/es active Active
- 2015-07-29 BR BR112017001821A patent/BR112017001821A2/pt not_active Application Discontinuation
- 2015-07-29 EA EA201790280A patent/EA034081B1/ru not_active IP Right Cessation
- 2015-07-29 CN CN201580052319.1A patent/CN106922148B/zh active Active
- 2015-07-29 JP JP2017504173A patent/JP6721568B2/ja active Active
- 2015-07-29 EP EP15744216.1A patent/EP3174557B1/en active Active
- 2015-07-29 EP EP18199948.3A patent/EP3453406B1/en active Active
- 2015-07-29 CA CA2950381A patent/CA2950381C/en active Active
- 2015-07-29 AU AU2015295349A patent/AU2015295349B2/en active Active
- 2015-07-29 KR KR1020177005614A patent/KR102048855B1/ko active Active
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2017
- 2017-01-17 IL IL250161A patent/IL250161B/en active IP Right Grant
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