JP2018512145A5 - - Google Patents
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- JP2018512145A5 JP2018512145A5 JP2017551301A JP2017551301A JP2018512145A5 JP 2018512145 A5 JP2018512145 A5 JP 2018512145A5 JP 2017551301 A JP2017551301 A JP 2017551301A JP 2017551301 A JP2017551301 A JP 2017551301A JP 2018512145 A5 JP2018512145 A5 JP 2018512145A5
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- Prior art keywords
- amino acid
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- acid sequence
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- variant
- Prior art date
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims description 28
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 28
- 238000006467 substitution reaction Methods 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 102000043129 MHC class I family Human genes 0.000 claims description 10
- 108091054437 MHC class I family Proteins 0.000 claims description 10
- 239000012636 effector Substances 0.000 claims description 9
- 230000004068 intracellular signaling Effects 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 7
- 108091007433 antigens Proteins 0.000 claims description 7
- 102000036639 antigens Human genes 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 7
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 6
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 6
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 4
- 230000009977 dual effect Effects 0.000 claims description 4
- 229940127121 immunoconjugate Drugs 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 3
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 3
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 230000002601 intratumoral effect Effects 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 108700028369 Alleles Proteins 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 102100027207 CD27 antigen Human genes 0.000 claims description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 2
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 2
- -1 CD3ζ Proteins 0.000 claims description 2
- 108010029697 CD40 Ligand Proteins 0.000 claims description 2
- 102100032937 CD40 ligand Human genes 0.000 claims description 2
- 208000021309 Germ cell tumor Diseases 0.000 claims description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 2
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 230000001394 metastastic effect Effects 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021055296A JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142958P | 2015-04-03 | 2015-04-03 | |
| US62/142,958 | 2015-04-03 | ||
| US201562244653P | 2015-10-21 | 2015-10-21 | |
| US62/244,653 | 2015-10-21 | ||
| US201662304915P | 2016-03-07 | 2016-03-07 | |
| US62/304,915 | 2016-03-07 | ||
| PCT/US2016/025755 WO2016161390A1 (en) | 2015-04-03 | 2016-04-01 | Constructs targeting afp peptide/mhc complexes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021055296A Division JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512145A JP2018512145A (ja) | 2018-05-17 |
| JP2018512145A5 true JP2018512145A5 (enExample) | 2019-05-09 |
| JP6903587B2 JP6903587B2 (ja) | 2021-07-14 |
Family
ID=57004627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551301A Active JP6903587B2 (ja) | 2015-04-03 | 2016-04-01 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
| JP2021055296A Pending JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021055296A Pending JP2021101723A (ja) | 2015-04-03 | 2021-03-29 | Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20180208658A1 (enExample) |
| EP (1) | EP3277314A4 (enExample) |
| JP (2) | JP6903587B2 (enExample) |
| KR (1) | KR102721595B1 (enExample) |
| CN (3) | CN114478791A (enExample) |
| AU (2) | AU2016243026B2 (enExample) |
| CA (1) | CA2979732A1 (enExample) |
| HK (1) | HK1249048A1 (enExample) |
| IL (2) | IL254852B (enExample) |
| MX (1) | MX2017012352A (enExample) |
| MY (1) | MY186708A (enExample) |
| RU (2) | RU2754041C2 (enExample) |
| SG (2) | SG11201707490SA (enExample) |
| TW (2) | TW202313691A (enExample) |
| WO (1) | WO2016161390A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| EP3277314A4 (en) * | 2015-04-03 | 2018-08-29 | Eureka Therapeutics, Inc. | Constructs targeting afp peptide/mhc complexes and uses thereof |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| IL295398B2 (en) | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
| CA3025757A1 (en) | 2016-05-27 | 2017-11-30 | Orum Therapeutics Inc. | Cytosol-penetrating antibody and use thereof |
| WO2018053069A1 (en) * | 2016-09-16 | 2018-03-22 | The Brigham And Women's Hospital, Inc. | Blockade of alphafetoprotein (afp) interactions with beta2-microglobulin associated molecules |
| EP3579866A4 (en) * | 2017-02-08 | 2020-12-09 | Dragonfly Therapeutics, Inc. | HEAVY CHAIN VARIABLE ANTIBODY DOMAINS WITH NKG2D RECEPTOR AIMING |
| KR20240023449A (ko) | 2017-02-08 | 2024-02-21 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| JP7685821B2 (ja) | 2017-02-20 | 2025-05-30 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｈｅｒ２、ＮＫＧ２ＤおよびＣＤ１６に結合するタンパク質 |
| JP6761113B2 (ja) * | 2017-03-27 | 2020-09-23 | ノイルイミューン・バイオテック株式会社 | キメラ抗原受容体 |
| AU2018256436B2 (en) | 2017-04-19 | 2024-12-05 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
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| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
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| CN110872346A (zh) * | 2018-08-30 | 2020-03-10 | 天津天锐生物科技有限公司 | 一种识别hla-a2分子与fmnkfiyei短肽形成的复合物的单域抗体 |
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| CN111662374B (zh) * | 2019-03-08 | 2023-01-24 | 香雪生命科学技术（广东）有限公司 | 一种识别afp抗原的高亲和力tcr |
| CN113321725B (zh) * | 2020-02-28 | 2024-06-11 | 香雪生命科学技术（广东）有限公司 | 一种识别afp的t细胞受体 |
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2016
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- 2016-04-01 CN CN202210006585.2A patent/CN114478791A/zh active Pending
- 2016-04-01 US US15/563,912 patent/US20180208658A1/en not_active Abandoned
- 2016-04-01 SG SG11201707490SA patent/SG11201707490SA/en unknown
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- 2016-04-01 CA CA2979732A patent/CA2979732A1/en active Pending
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