CA2979732A1 - Constructs targeting afp peptide/mhc complexes and uses thereof - Google Patents

Constructs targeting afp peptide/mhc complexes and uses thereof Download PDF

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Publication number
CA2979732A1
CA2979732A1 CA2979732A CA2979732A CA2979732A1 CA 2979732 A1 CA2979732 A1 CA 2979732A1 CA 2979732 A CA2979732 A CA 2979732A CA 2979732 A CA2979732 A CA 2979732A CA 2979732 A1 CA2979732 A1 CA 2979732A1
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Prior art keywords
amino acid
seq
acid sequence
amc
variant
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CA2979732A
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English (en)
French (fr)
Inventor
Cheng Liu
Hong Liu
Yiyang XU
Jingyi Xiang
Li Long
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Eureka Therapeutics Inc
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Eureka Therapeutics Inc
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Publication of CA2979732A1 publication Critical patent/CA2979732A1/en
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CA2979732A 2015-04-03 2016-04-01 Constructs targeting afp peptide/mhc complexes and uses thereof Pending CA2979732A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562142958P 2015-04-03 2015-04-03
US62/142,958 2015-04-03
US201562244653P 2015-10-21 2015-10-21
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