EP1253930A4 - Method and compositions for treating hepatocellular cancer - Google Patents

Method and compositions for treating hepatocellular cancer

Info

Publication number
EP1253930A4
EP1253930A4 EP01910587A EP01910587A EP1253930A4 EP 1253930 A4 EP1253930 A4 EP 1253930A4 EP 01910587 A EP01910587 A EP 01910587A EP 01910587 A EP01910587 A EP 01910587A EP 1253930 A4 EP1253930 A4 EP 1253930A4
Authority
EP
European Patent Office
Prior art keywords
compositions
hepatocellular cancer
treating hepatocellular
treating
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01910587A
Other languages
German (de)
French (fr)
Other versions
EP1253930A2 (en
Inventor
James S Economou
Lisa H Butterfield
Bruguera Antoni Ribas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP1253930A2 publication Critical patent/EP1253930A2/en
Publication of EP1253930A4 publication Critical patent/EP1253930A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46448—Cancer antigens from embryonic or fetal origin
    • A61K39/464481—Alpha-feto protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/53—Liver
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP01910587A 2000-02-10 2001-02-12 Method and compositions for treating hepatocellular cancer Ceased EP1253930A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18196600P 2000-02-10 2000-02-10
US181966 2000-02-10
US66025200A 2000-09-12 2000-09-12
US660252 2000-09-12
US66250500A 2000-09-14 2000-09-14
US662505 2000-09-14
PCT/US2001/004539 WO2001058922A2 (en) 2000-02-10 2001-02-12 Method and compositions for treating hepatocellular cancer

Publications (2)

Publication Number Publication Date
EP1253930A2 EP1253930A2 (en) 2002-11-06
EP1253930A4 true EP1253930A4 (en) 2003-05-21

Family

ID=27391498

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01910587A Ceased EP1253930A4 (en) 2000-02-10 2001-02-12 Method and compositions for treating hepatocellular cancer

Country Status (7)

Country Link
EP (1) EP1253930A4 (en)
JP (1) JP3876162B2 (en)
KR (1) KR100482920B1 (en)
CN (1) CN1255427C (en)
AU (1) AU2001238179A1 (en)
HK (1) HK1046853A1 (en)
WO (1) WO2001058922A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100985914B1 (en) * 2006-12-13 2010-10-08 주식회사 바이오리더스 Cell Surface Expression Vector for liver Cancer Specific Antigen Alpha-fetoprotein and Microorganism Transformed by Thereof
WO2008113970A2 (en) * 2007-03-16 2008-09-25 Ucl Business Plc Peptides
KR100900742B1 (en) * 2007-05-17 2009-06-08 크레아젠 주식회사 Animal Models Carrying Tumors Expressing Human Liver Cancer-Specific Antigen and Method for Analyzing Prevention and Treatment Efficacy of Dendritic Cells-Derived Immunotherapeutics Using the Above
US8541543B2 (en) * 2007-11-20 2013-09-24 Academia Sinica Peptides specific for hepatocellular carcinoma cells and applications thereof
US20180208658A1 (en) * 2015-04-03 2018-07-26 Eureka Therapeutics, Inc. Constructs targeting afp peptide/mhc complexes and uses thereof
CN113072636B (en) * 2020-01-06 2024-05-28 香雪生命科学技术（广东）有限公司 T cell receptor for identifying AFP and coding sequence thereof
CN113321725B (en) * 2020-02-28 2024-06-11 香雪生命科学技术（广东）有限公司 T cell receptor for identifying AFP

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1226551B (en) * 1988-07-29 1991-01-24 Sclavo Spa IMMUNOLOGICALLY ACTIVE SYNTHETIC PEPTIDE CAPABLE OF INDUCING THE PRODUCTION OF ANTIBODIES WITH HIGH SPECIFICITY TOWARDS ALPHA-PHETOPROTEIN AND THEIR USE IN THE DIAGNOSTIC FIELD
JPH10513347A (en) * 1995-01-24 1998-12-22 ロバート エイ． マルギタ Recombinant human α-fetoprotein and use thereof
WO1998035981A1 (en) * 1997-02-13 1998-08-20 The Regents Of The University Of California Prevention and treatment of hepatocellular cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUTTERFIELD L H ET AL: "T cell responses to HLA-A* 0201-restricted peptides derived from human [alpha] fetoprotein", JOURNAL OF IMMUNOLOGY 15 APR 2001 UNITED STATES, vol. 166, no. 8, 15 April 2001 (2001-04-15), pages 5300 - 5308, XP002235963, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
EP1253930A2 (en) 2002-11-06
KR100482920B1 (en) 2005-04-14
HK1046853A1 (en) 2003-01-30
AU2001238179A1 (en) 2001-08-20
CN1255427C (en) 2006-05-10
WO2001058922A9 (en) 2002-10-17
CN1398187A (en) 2003-02-19
WO2001058922A3 (en) 2002-02-14
WO2001058922A2 (en) 2001-08-16
JP3876162B2 (en) 2007-01-31
JP2003522195A (en) 2003-07-22
KR20020073203A (en) 2002-09-19

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