JP2012531212A5 - - Google Patents
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- JP2012531212A5 JP2012531212A5 JP2012517983A JP2012517983A JP2012531212A5 JP 2012531212 A5 JP2012531212 A5 JP 2012531212A5 JP 2012517983 A JP2012517983 A JP 2012517983A JP 2012517983 A JP2012517983 A JP 2012517983A JP 2012531212 A5 JP2012531212 A5 JP 2012531212A5
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- 235000018102 proteins Nutrition 0.000 claims 67
- 102000004169 proteins and genes Human genes 0.000 claims 67
- 108090000623 proteins and genes Proteins 0.000 claims 67
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 22
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 229920001184 polypeptide Polymers 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 230000001268 conjugating effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 101150047061 tag-72 gene Proteins 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 2
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 2
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 2
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 2
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 2
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 2
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
- 229940116978 human epidermal growth factor Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009903127 | 2009-07-03 | ||
| AU2009903127A AU2009903127A0 (en) | 2009-07-03 | Immuno-conjugates and methods for producing them | |
| US22335309P | 2009-07-06 | 2009-07-06 | |
| US61/223,353 | 2009-07-06 | ||
| US25670309P | 2009-10-30 | 2009-10-30 | |
| US61/256,703 | 2009-10-30 | ||
| PCT/AU2010/000847 WO2011000054A1 (en) | 2009-07-03 | 2010-07-02 | Immuno-conjugates and methods for producing them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015653A Division JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012531212A JP2012531212A (ja) | 2012-12-10 |
| JP2012531212A5 true JP2012531212A5 (enExample) | 2013-08-15 |
Family
ID=43410379
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517983A Withdrawn JP2012531212A (ja) | 2009-07-03 | 2010-07-02 | イムノコンジュゲート及びその作製方法 |
| JP2016015653A Active JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015653A Active JP6371319B2 (ja) | 2009-07-03 | 2016-01-29 | イムノコンジュゲート及びその作製方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9290577B2 (enExample) |
| EP (1) | EP2448966B1 (enExample) |
| JP (2) | JP2012531212A (enExample) |
| KR (1) | KR101962476B1 (enExample) |
| AU (1) | AU2010268690B2 (enExample) |
| CA (1) | CA2766409C (enExample) |
| SG (1) | SG176947A1 (enExample) |
| WO (1) | WO2011000054A1 (enExample) |
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| SG181814A1 (en) | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
| JP2014518615A (ja) | 2011-04-22 | 2014-08-07 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | 前立腺特異的膜抗原結合タンパク質および関連組成物ならびに方法 |
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| CN108862289B (zh) * | 2018-07-26 | 2021-10-15 | 南京邮电大学 | 一种小粒径大孔径的介孔二氧化硅纳米粒子及其制备方法 |
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2010
- 2010-07-02 KR KR1020127002857A patent/KR101962476B1/ko active Active
- 2010-07-02 SG SG2011094844A patent/SG176947A1/en unknown
- 2010-07-02 AU AU2010268690A patent/AU2010268690B2/en active Active
- 2010-07-02 WO PCT/AU2010/000847 patent/WO2011000054A1/en not_active Ceased
- 2010-07-02 EP EP10793442.4A patent/EP2448966B1/en active Active
- 2010-07-02 US US13/383,578 patent/US9290577B2/en active Active
- 2010-07-02 JP JP2012517983A patent/JP2012531212A/ja not_active Withdrawn
- 2010-07-02 CA CA2766409A patent/CA2766409C/en active Active
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2016
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