JP2019528693A5 - - Google Patents
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- JP2019528693A5 JP2019528693A5 JP2019510849A JP2019510849A JP2019528693A5 JP 2019528693 A5 JP2019528693 A5 JP 2019528693A5 JP 2019510849 A JP2019510849 A JP 2019510849A JP 2019510849 A JP2019510849 A JP 2019510849A JP 2019528693 A5 JP2019528693 A5 JP 2019528693A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 36
- 125000003275 alpha amino acid group Chemical group 0.000 claims 34
- 206010009944 Colon cancer Diseases 0.000 claims 10
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 230000002265 prevention Effects 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 229940122985 Peptide agonist Drugs 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102100022144 Achaete-scute homolog 2 Human genes 0.000 claims 5
- 101000901109 Homo sapiens Achaete-scute homolog 2 Proteins 0.000 claims 5
- 102000002689 Toll-like receptor Human genes 0.000 claims 4
- 108020000411 Toll-like receptor Proteins 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 241000283070 Equus zebra Species 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000000763 Survivin Human genes 0.000 claims 3
- 108010002687 Survivin Proteins 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 230000035699 permeability Effects 0.000 claims 3
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims 2
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 102100024333 Toll-like receptor 2 Human genes 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102100026245 E3 ubiquitin-protein ligase RNF43 Human genes 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 101000692702 Homo sapiens E3 ubiquitin-protein ligase RNF43 Proteins 0.000 claims 1
- 101100452137 Homo sapiens IGF2BP3 gene Proteins 0.000 claims 1
- 101000801539 Homo sapiens Mitochondrial import receptor subunit TOM34 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims 1
- 102100037920 Insulin-like growth factor 2 mRNA-binding protein 3 Human genes 0.000 claims 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 1
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 1
- 102100033583 Mitochondrial import receptor subunit TOM34 Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 239000012270 PD-1 inhibitor Substances 0.000 claims 1
- 239000012668 PD-1-inhibitor Substances 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000012737 microarray-based gene expression Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 1
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2016/072475 | 2016-09-21 | ||
| EP2016072475 | 2016-09-21 | ||
| PCT/EP2017/073954 WO2018055060A1 (en) | 2016-09-21 | 2017-09-21 | Fusion comprising a cell penetrating peptide, a multi epitope and a tlr peptide agonist for treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528693A JP2019528693A (ja) | 2019-10-17 |
| JP2019528693A5 true JP2019528693A5 (enExample) | 2020-11-05 |
| JP7346291B2 JP7346291B2 (ja) | 2023-09-19 |
Family
ID=60037562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019510849A Active JP7346291B2 (ja) | 2016-09-21 | 2017-09-21 | 癌を治療するための細胞透過性ペプチド、マルチエピトープ、及びｔｌｒペプチドアゴニストを含む融合体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20190255165A1 (enExample) |
| EP (1) | EP3515476B1 (enExample) |
| JP (1) | JP7346291B2 (enExample) |
| KR (2) | KR20190057345A (enExample) |
| CN (1) | CN109963585B (enExample) |
| AU (1) | AU2017331949B2 (enExample) |
| CA (1) | CA3031170A1 (enExample) |
| CL (3) | CL2019000694A1 (enExample) |
| DK (1) | DK3515476T3 (enExample) |
| ES (1) | ES2983085T3 (enExample) |
| HU (1) | HUE067838T2 (enExample) |
| IL (1) | IL265479B (enExample) |
| MX (1) | MX2019002968A (enExample) |
| PL (1) | PL3515476T3 (enExample) |
| WO (1) | WO2018055060A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180133327A1 (en) | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| CA3010779A1 (en) | 2016-03-16 | 2017-09-21 | Amal Therapeutics Sa | Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist for use in medicine |
| EP3515476B1 (en) * | 2016-09-21 | 2024-05-22 | Amal Therapeutics SA | Fusion comprising a cell penetrating peptide, a multiepitope and a tlr peptide agonist for treatment of cancer |
| KR20240149976A (ko) | 2017-04-04 | 2024-10-15 | 바린투스 바이오테라퓨틱스 노쓰 아메리카, 인크. | 펩티드-기반 백신, 그의 제조 방법, 및 면역 반응을 유도하기 위한 그의 용도 |
| US12121573B2 (en) | 2019-07-14 | 2024-10-22 | Tianxin Wang | Methods and agents including STING agonist to treat tumor |
| US11945850B2 (en) * | 2018-09-17 | 2024-04-02 | Immatics Biotechnologies Gmbh | B*44 restricted peptides for use in immunotherapy against cancers and related methods |
| JP2022536695A (ja) * | 2019-06-12 | 2022-08-18 | ビオンテック ユーエス インコーポレイテッド | 新抗原組成物およびその使用 |
| CN110448689A (zh) * | 2019-08-06 | 2019-11-15 | 太仓美诺恒康生物技术有限公司 | mRNA疫苗及其试剂盒、应用 |
| US20220347315A1 (en) * | 2019-11-22 | 2022-11-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for increasing transduction efficiency with cell membrane fusion proteins |
| EP3827840A1 (en) | 2019-11-29 | 2021-06-02 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Teipp peptide variant and uses thereof |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| CN116348137A (zh) * | 2020-09-14 | 2023-06-27 | 勃林格殷格翰国际有限公司 | 异源初免加强疫苗 |
| WO2022079175A1 (en) * | 2020-10-14 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
| CN113480666B (zh) * | 2021-08-13 | 2024-01-26 | 郑州伊美诺生物技术有限公司 | Ca153融合蛋白及其制备方法和ca153检测质控品或校准品 |
| CN113786481A (zh) * | 2021-09-27 | 2021-12-14 | 深圳市中佳生物医疗科技有限公司 | 一种抗肿瘤疫苗及其制备方法 |
| MX2024011238A (es) * | 2022-03-16 | 2024-09-19 | Boehringer Ingelheim Int | Antigenos tumorales, compuestos que comprenden los antigenos tumorales kras, tpx2 o aurka y usos de los mismos. |
| KR102823824B1 (ko) | 2022-08-10 | 2025-06-24 | 강원대학교산학협력단 | Pde5 억제제 특이적 결합 도메인, 재조합 단백질 및 이의 용도 |
| KR102886457B1 (ko) | 2022-10-14 | 2025-11-18 | 강원대학교산학협력단 | mTOR 억제제 특이적 결합 도메인, 재조합 단백질 및 이의 용도 |
| GB202216453D0 (en) * | 2022-11-04 | 2022-12-21 | Lisziewicz Julianna | Identification of antigens which induce t-cell responses |
| WO2024196664A1 (en) * | 2023-03-17 | 2024-09-26 | University Of Washington | Dna vaccine targeting overexpressed antigens in colorectal cancer |
| JP7723457B2 (ja) * | 2023-07-03 | 2025-08-14 | メスキュージェナシス株式会社 | 細胞膜透過性を有するペプチドおよびそのスクリーニング方法 |
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| CN109069561A (zh) | 2016-01-11 | 2018-12-21 | 图恩斯通有限合伙公司 | 溶瘤病毒和检查点抑制剂组合疗法 |
| CA3010779A1 (en) | 2016-03-16 | 2017-09-21 | Amal Therapeutics Sa | Combination of an immune checkpoint modulator and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist for use in medicine |
| US20190151437A1 (en) | 2016-05-09 | 2019-05-23 | Turnstone Limited Partnership | Combination prime: boost therapy |
| PL417980A1 (pl) | 2016-07-16 | 2018-01-29 | Univ Warszawski | Nowe fosfotriazolowe analogi kapu końca 5' mRNA, kompozycja je zawierająca, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA, białka i peptydu |
| US11052149B2 (en) | 2016-09-19 | 2021-07-06 | The University Of North Carolina At Chapel Hill | Methods and compositions for inducing an immune response |
| EP3515476B1 (en) | 2016-09-21 | 2024-05-22 | Amal Therapeutics SA | Fusion comprising a cell penetrating peptide, a multiepitope and a tlr peptide agonist for treatment of cancer |
| CA3058807A1 (en) | 2017-04-03 | 2018-10-11 | Neon Therapeutics, Inc. | Protein antigens and uses thereof |
| EP3746104A1 (en) | 2018-02-02 | 2020-12-09 | Novartis AG | Combination of sting agonist and il-15/il15-ra for the treatment of cancer |
| CA3110102A1 (en) | 2018-06-20 | 2019-12-26 | Yale University | Rig-i agonists and treatments using same |
| WO2020010451A1 (en) | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| CN116348137A (zh) | 2020-09-14 | 2023-06-27 | 勃林格殷格翰国际有限公司 | 异源初免加强疫苗 |
| WO2022079175A1 (en) * | 2020-10-14 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist |
-
2017
- 2017-09-21 EP EP17780656.9A patent/EP3515476B1/en active Active
- 2017-09-21 ES ES17780656T patent/ES2983085T3/es active Active
- 2017-09-21 JP JP2019510849A patent/JP7346291B2/ja active Active
- 2017-09-21 DK DK17780656.9T patent/DK3515476T3/da active
- 2017-09-21 CN CN201780069631.0A patent/CN109963585B/zh active Active
- 2017-09-21 IL IL265479A patent/IL265479B/en unknown
- 2017-09-21 AU AU2017331949A patent/AU2017331949B2/en active Active
- 2017-09-21 HU HUE17780656A patent/HUE067838T2/hu unknown
- 2017-09-21 CA CA3031170A patent/CA3031170A1/en active Pending
- 2017-09-21 KR KR1020197011382A patent/KR20190057345A/ko not_active Ceased
- 2017-09-21 MX MX2019002968A patent/MX2019002968A/es unknown
- 2017-09-21 US US16/331,398 patent/US20190255165A1/en not_active Abandoned
- 2017-09-21 WO PCT/EP2017/073954 patent/WO2018055060A1/en not_active Ceased
- 2017-09-21 PL PL17780656.9T patent/PL3515476T3/pl unknown
- 2017-09-21 KR KR1020237029678A patent/KR102879364B1/ko active Active
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2019
- 2019-03-18 CL CL2019000694A patent/CL2019000694A1/es unknown
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2020
- 2020-11-25 US US17/104,786 patent/US11338027B2/en active Active
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2021
- 2021-06-11 CL CL2021001541A patent/CL2021001541A1/es unknown
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2022
- 2022-04-12 US US17/718,975 patent/US12220387B2/en active Active
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2023
- 2023-07-31 CL CL2023002252A patent/CL2023002252A1/es unknown
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