CN116041538A - 修饰的嵌合受体及相关组合物和方法 - Google Patents
修饰的嵌合受体及相关组合物和方法 Download PDFInfo
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- CN116041538A CN116041538A CN202211269666.8A CN202211269666A CN116041538A CN 116041538 A CN116041538 A CN 116041538A CN 202211269666 A CN202211269666 A CN 202211269666A CN 116041538 A CN116041538 A CN 116041538A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Peptides Or Proteins (AREA)
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262911P | 2015-12-03 | 2015-12-03 | |
| US62/262,911 | 2015-12-03 | ||
| US201662348130P | 2016-06-09 | 2016-06-09 | |
| US62/348,130 | 2016-06-09 | ||
| CN201680080438.2A CN108884140B (zh) | 2015-12-03 | 2016-12-02 | 修饰的嵌合受体及相关组合物和方法 |
| PCT/US2016/064861 WO2017096329A1 (en) | 2015-12-03 | 2016-12-02 | Modified chimeric receptors and related compositions and methods |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680080438.2A Division CN108884140B (zh) | 2015-12-03 | 2016-12-02 | 修饰的嵌合受体及相关组合物和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116041538A true CN116041538A (zh) | 2023-05-02 |
Family
ID=57851322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680080438.2A Active CN108884140B (zh) | 2015-12-03 | 2016-12-02 | 修饰的嵌合受体及相关组合物和方法 |
| CN202211269666.8A Pending CN116041538A (zh) | 2015-12-03 | 2016-12-02 | 修饰的嵌合受体及相关组合物和方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680080438.2A Active CN108884140B (zh) | 2015-12-03 | 2016-12-02 | 修饰的嵌合受体及相关组合物和方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12139526B2 (enExample) |
| EP (2) | EP4212547A1 (enExample) |
| JP (2) | JP7184645B2 (enExample) |
| CN (2) | CN108884140B (enExample) |
| AU (1) | AU2016363025B2 (enExample) |
| CA (1) | CA3007262A1 (enExample) |
| ES (1) | ES2940607T3 (enExample) |
| MA (1) | MA43380A (enExample) |
| MX (1) | MX2018006789A (enExample) |
| WO (1) | WO2017096329A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| MY184699A (en) | 2014-04-16 | 2021-04-18 | Juno Therapeutics Gmbh | Methods, kits and apparatus for expanding a population of cells |
| AU2015249554B2 (en) | 2014-04-23 | 2021-08-19 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| KR102804498B1 (ko) | 2014-12-03 | 2025-05-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 방법 및 조성물 |
| US11384350B2 (en) | 2014-12-15 | 2022-07-12 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing |
| SI3240805T1 (sl) | 2014-12-15 | 2025-04-30 | The Regents Of The University Of California | Bispecifični or-gate himerni antigenski receptor, odziv na cd19 in cd20 |
| IL294055A (en) * | 2015-03-20 | 2022-08-01 | Childrens Nat Medical Ct | Generating virus or other antigen-specific t cells from a naive t cell population |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| CN108474002B (zh) | 2015-10-22 | 2023-05-23 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
| US11701384B2 (en) | 2016-09-02 | 2023-07-18 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| EP3568469A4 (en) * | 2017-02-21 | 2020-11-11 | Eutilex Co., Ltd. | COMPOSITIONS OF CAR-T CELLS DIRECTED AGAINST HLA-DR AND THEIR MANUFACTURING AND USE PROCEDURES |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP3658163A4 (en) * | 2017-07-25 | 2021-08-04 | Board Of Regents, The University Of Texas System | IMPROVED ANTIGENIC CHEMICAL RECEPTORS AND THEIR USES |
| EP4279584A3 (en) * | 2017-10-16 | 2024-03-06 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd22 immunotherapy |
| WO2019090003A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for b-cell maturation antigen (bcma) |
| PL3704230T3 (pl) | 2017-11-01 | 2025-02-24 | Juno Therapeutics, Inc. | Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie |
| SG11202003427XA (en) | 2017-11-06 | 2020-05-28 | Juno Therapeutics Inc | Combination of a cell therapy and a gamma secretase inhibitor |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CA3103610A1 (en) * | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| CN113474450A (zh) * | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
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