JP2018515085A5 - - Google Patents
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- JP2018515085A5 JP2018515085A5 JP2017557310A JP2017557310A JP2018515085A5 JP 2018515085 A5 JP2018515085 A5 JP 2018515085A5 JP 2017557310 A JP2017557310 A JP 2017557310A JP 2017557310 A JP2017557310 A JP 2017557310A JP 2018515085 A5 JP2018515085 A5 JP 2018515085A5
- Authority
- JP
- Japan
- Prior art keywords
- ser
- lys
- arg
- asp
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166179 | 2015-05-04 | ||
| EP15166179.0 | 2015-05-04 | ||
| EP15167917.2 | 2015-05-18 | ||
| EP15167917 | 2015-05-18 | ||
| EP15002702 | 2015-09-17 | ||
| EP15002702.7 | 2015-09-17 | ||
| EP15192870 | 2015-11-04 | ||
| EP15192870.2 | 2015-11-04 | ||
| EP16150705.8 | 2016-01-11 | ||
| EP16150705 | 2016-01-11 | ||
| EP16000862 | 2016-04-15 | ||
| EP16000862.9 | 2016-04-15 | ||
| PCT/EP2016/060041 WO2016177802A1 (en) | 2015-05-04 | 2016-05-04 | Anti-cancer fusion polypeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515085A JP2018515085A (ja) | 2018-06-14 |
| JP2018515085A5 true JP2018515085A5 (enExample) | 2019-06-06 |
| JP6783797B2 JP6783797B2 (ja) | 2020-11-11 |
Family
ID=55948826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557310A Expired - Fee Related JP6783797B2 (ja) | 2015-05-04 | 2016-05-04 | 抗がん融合ポリペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10865250B2 (enExample) |
| EP (2) | EP4378962A3 (enExample) |
| JP (1) | JP6783797B2 (enExample) |
| KR (1) | KR20170138574A (enExample) |
| CN (2) | CN107636014B (enExample) |
| AU (1) | AU2016258977C1 (enExample) |
| BR (1) | BR112017020434A2 (enExample) |
| CA (1) | CA2980840A1 (enExample) |
| MX (1) | MX2017014083A (enExample) |
| RU (1) | RU2727165C2 (enExample) |
| SG (1) | SG11201708334RA (enExample) |
| WO (1) | WO2016177802A1 (enExample) |
| ZA (1) | ZA201705961B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| RU2736312C2 (ru) | 2015-05-04 | 2020-11-13 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Белки, специфичные в отношении cd137 |
| AU2016262845B2 (en) * | 2015-05-18 | 2020-07-23 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| EP3472207B1 (en) | 2016-06-20 | 2021-01-20 | F-Star Delta Limited | Binding molecules binding pd-l1 and lag-3 |
| TW201831513A (zh) | 2016-06-20 | 2018-09-01 | Ｆ星貝塔有限公司 | 結合物件(一) |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| EP3565843A1 (en) * | 2017-01-03 | 2019-11-13 | H. Hoffnabb-La Roche Ag | Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9 |
| GB201700345D0 (en) | 2017-01-09 | 2017-02-22 | F-Star Beta Ltd | Conditional agonists of immune responses |
| WO2018134279A1 (en) * | 2017-01-18 | 2018-07-26 | Pieris Pharmaceuticals Gmbh | Novel fusion polypeptides specific for lag-3 and pd-1 |
| SG11201907753TA (en) * | 2017-02-24 | 2019-09-27 | Macrogenics Inc | Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof |
| BR112020000719A2 (pt) | 2017-07-11 | 2020-07-14 | Compass Therapeutics Llc | anticorpos agonistas que ligam o cd137 humano e seus usos |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| JP7312168B2 (ja) * | 2017-11-13 | 2023-07-20 | クレッシェンド、バイオロジックス、リミテッド | Ｃｄ１３７に結合するシングルドメイン抗体 |
| WO2019100052A2 (en) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| AU2018387741B2 (en) | 2017-12-19 | 2025-09-25 | Invox Pharma Limited | FC binding fragments comprising a PD-L1 antigen-binding site |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| TW202003462A (zh) | 2018-03-26 | 2020-01-16 | 德商４Ｓｃ製藥公司 | 用於癌症療法的包括ｈｄａｃ抑制劑和ｃｄ１３７激動劑之組合 |
| WO2019197600A1 (en) * | 2018-04-13 | 2019-10-17 | F. Hoffmann-La Roche Ag | Her2-targeting antigen binding molecules comprising 4-1bbl |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| GB201811404D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| US12344672B2 (en) | 2018-07-12 | 2025-07-01 | Invox Pharma Limited | Antibody molecules that bind PD-L1 and CD137 |
| MX2021000399A (es) | 2018-07-12 | 2021-05-27 | F Star Therapeutics Ltd | Moleculas de anticuerpo que se unen a cd137 y ox40. |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| HRP20230590T2 (hr) * | 2018-07-31 | 2024-02-16 | Pieris Pharmaceuticals Gmbh | Novi fuzijski protein specifičan za cd137 i pd-l1 |
| WO2020043683A1 (en) * | 2018-08-27 | 2020-03-05 | Pieris Pharmaceuticals Gmbh | Combination therapies comprising cd137/her2 bispecific agents and pd-1 axis inhibitors and uses thereof |
| JP7476219B2 (ja) * | 2019-02-26 | 2024-04-30 | ピエリス ファーマシューティカルズ ゲーエムベーハー | Ｃｄ１３７およびｇｐｃ３に特異的な新規融合タンパク質 |
| KR20210146999A (ko) * | 2019-03-29 | 2021-12-06 | 피어이스 파마슈티컬즈 게엠베하 | 리포칼린 뮤테인의 흡입 투여 |
| EP3952996A1 (en) | 2019-04-12 | 2022-02-16 | F. Hoffmann-La Roche AG | Bispecific antigen binding molecules comprising lipocalin muteins |
| JP7725446B2 (ja) * | 2019-07-26 | 2025-08-19 | ユハン コーポレーション | 抗ｈｅｒ２／抗４－１ｂｂ二重特異性抗体及びその使用 |
| EP4054718A1 (en) | 2019-11-04 | 2022-09-14 | Pieris Pharmaceuticals GmbH | Her2/4-1bb bispecific fusion proteins for the treatment of cancer |
| CN115151573A (zh) * | 2020-02-28 | 2022-10-04 | 上海复宏汉霖生物技术股份有限公司 | 抗cd137构建体、多特异性抗体及其用途 |
| KR20230042524A (ko) * | 2020-08-07 | 2023-03-28 | 주식회사 유틸렉스 | 항-her2 / 항-4-1bb 이중특이적 항체 및 이의 용도 |
| US20230366884A1 (en) | 2020-09-18 | 2023-11-16 | Pieris Pharmaceuticals Gmbh | Biomarker methods and uses |
| JP2024504388A (ja) * | 2021-01-25 | 2024-01-31 | ユーハン・コーポレイション | 抗４－１ｂｂ／抗ｈｅｒ２二重特異性抗体の精製方法 |
| AU2022241940A1 (en) | 2021-03-23 | 2023-10-26 | Pieris Pharmaceuticals Gmbh | Her2/4-1bb bispecific fusion proteins for the treatment of cancer |
| WO2022200478A1 (en) | 2021-03-24 | 2022-09-29 | Pieris Pharmaceuticals Gmbh | Tumor treatment with a 4-1bb/her2-bispecific agent and a her2-targeted tyrosine kinase inhibitor |
| JP7365654B2 (ja) | 2021-04-22 | 2023-10-20 | アステラス製薬株式会社 | 抗ｃｌｄｎ４－抗ｃｄ１３７二重特異性抗体 |
| WO2023180523A1 (en) | 2022-03-24 | 2023-09-28 | Pieris Pharmaceuticals Gmbh | Process for purifying fusion proteins |
| KR20250075621A (ko) | 2022-09-20 | 2025-05-28 | 바이오세우스 인크. | 항체 및 종양 저항에서의 이의 용도 |
| JP7730432B2 (ja) * | 2022-10-19 | 2025-08-27 | アステラス製薬株式会社 | がん治療におけるｐｄ－１シグナル阻害剤との組み合わせによる抗ｃｌｄｎ４－抗ｃｄ１３７二重特異性抗体の使用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| DE3779221D1 (de) | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| WO1995031479A1 (en) | 1994-05-18 | 1995-11-23 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998016873A1 (en) | 1996-10-14 | 1998-04-23 | Firm Forsat Ltd. | Method for preparing dispersions of chromogenic components |
| CA2279547A1 (en) | 1997-01-31 | 1998-08-06 | University Of Rochester | Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response |
| EP1009762A2 (en) | 1997-08-06 | 2000-06-21 | ZymoGenetics, Inc. | Lipocalin homologs |
| US20140080177A1 (en) | 1997-09-26 | 2014-03-20 | Pieris Ag | Anticalins |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| TR200003635T2 (tr) | 1998-06-08 | 2001-04-20 | F.Hoffmann-La Roche Ag | Peg-IFN-ALFA ve ribavirinin kronik hepatit C tedavisinde kullanılması. |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| CA2343917A1 (en) | 1998-10-19 | 2000-04-27 | Ariad Gene Therapeutics, Inc. | Materials and methods involving conditional retention domains |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| EP1430136A1 (en) | 2001-09-27 | 2004-06-23 | Pieris ProteoLab AG | Muteins of apolipoprotein d |
| AU2003264100A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| JP2007284351A (ja) | 2004-07-27 | 2007-11-01 | Osaka Bioscience Institute | アミロイド蛋白質の凝集を抑制する物質とその作用 |
| EP2899277A1 (en) | 2004-11-26 | 2015-07-29 | Pieris AG | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| JP2009509535A (ja) | 2005-09-27 | 2009-03-12 | アムニクス， インコーポレイテッド | タンパク様薬剤およびその使用 |
| CN104650213A (zh) * | 2006-08-01 | 2015-05-27 | 皮里斯股份公司 | 泪液脂质运载蛋白的突变蛋白及其获得方法 |
| JP5848006B2 (ja) | 2007-10-19 | 2016-01-27 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | Ｎｇａｌの検出用イムノアッセイ及びキット |
| EP2641919A3 (en) | 2007-11-30 | 2014-05-07 | Glaxo Group Limited | Antigen-binding constructs |
| EP2262531A1 (en) | 2008-03-08 | 2010-12-22 | Immungene, Inc. | Engineered fusion molecules immunotherapy in cancer and inflammatory diseases |
| CA2729322C (en) | 2008-06-24 | 2020-05-26 | Technische Universitaet Muenchen | Muteins of hngal and related proteins with affinity for a given target |
| EP2401296A1 (en) | 2009-02-24 | 2012-01-04 | Glaxo Group Limited | Multivalent and/or multispecific rankl-binding constructs |
| US20120076787A1 (en) | 2009-05-28 | 2012-03-29 | Peter Adamson | Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye |
| BR112012002709A2 (pt) | 2009-08-05 | 2019-04-30 | Pieris Ag | formulações de liberação controlada de muteínas de lipocalina |
| EP3660510A3 (en) * | 2009-12-07 | 2020-07-08 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target |
| CA3253628A1 (en) * | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| CA2808392C (en) | 2010-08-16 | 2020-03-10 | Pieris Pharmaceuticals Gmbh | Binding proteins for hepcidin |
| EP2640740B1 (en) | 2010-11-15 | 2017-03-15 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
| DK2646552T3 (en) | 2010-12-02 | 2017-10-23 | Pieris Pharmaceuticals Gmbh | MUTEINES OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR CTLA-4 |
| MY174248A (en) * | 2012-04-30 | 2020-04-01 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
| WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| EA037654B1 (ru) * | 2014-12-30 | 2021-04-27 | Селджин Корпорейшн | Анти-cd47-антитела и их применения |
| US11382963B2 (en) | 2015-01-12 | 2022-07-12 | Pieris Pharmaceuticals Gmbh | Engineered T cells and uses therefor |
| AU2016212087B2 (en) | 2015-01-28 | 2019-11-07 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for angiogenesis |
| BR112017017530A2 (pt) | 2015-02-18 | 2018-04-17 | Sanofi | proteínas específicas para pioverdina e pioquelina |
| RU2736312C2 (ru) | 2015-05-04 | 2020-11-13 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Белки, специфичные в отношении cd137 |
| US10273275B2 (en) | 2015-05-18 | 2019-04-30 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
-
2016
- 2016-05-04 AU AU2016258977A patent/AU2016258977C1/en not_active Ceased
- 2016-05-04 WO PCT/EP2016/060041 patent/WO2016177802A1/en not_active Ceased
- 2016-05-04 KR KR1020177034820A patent/KR20170138574A/ko active Pending
- 2016-05-04 CA CA2980840A patent/CA2980840A1/en active Pending
- 2016-05-04 JP JP2017557310A patent/JP6783797B2/ja not_active Expired - Fee Related
- 2016-05-04 MX MX2017014083A patent/MX2017014083A/es unknown
- 2016-05-04 EP EP24151494.2A patent/EP4378962A3/en not_active Withdrawn
- 2016-05-04 CN CN201680025273.9A patent/CN107636014B/zh active Active
- 2016-05-04 SG SG11201708334RA patent/SG11201708334RA/en unknown
- 2016-05-04 CN CN202111366682.4A patent/CN114316067A/zh active Pending
- 2016-05-04 RU RU2017135596A patent/RU2727165C2/ru active
- 2016-05-04 EP EP16721154.9A patent/EP3292148B1/en active Active
- 2016-05-04 US US15/571,561 patent/US10865250B2/en active Active
- 2016-05-04 BR BR112017020434A patent/BR112017020434A2/pt not_active Application Discontinuation
-
2017
- 2017-09-01 ZA ZA2017/05961A patent/ZA201705961B/en unknown
-
2020
- 2020-11-12 US US17/096,750 patent/US20210198380A1/en not_active Abandoned
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