RU2727165C2 - Слитый полипептид с противораковой активностью - Google Patents
Слитый полипептид с противораковой активностью Download PDFInfo
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- RU2727165C2 RU2727165C2 RU2017135596A RU2017135596A RU2727165C2 RU 2727165 C2 RU2727165 C2 RU 2727165C2 RU 2017135596 A RU2017135596 A RU 2017135596A RU 2017135596 A RU2017135596 A RU 2017135596A RU 2727165 C2 RU2727165 C2 RU 2727165C2
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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| EP3585431A4 (en) | 2017-02-24 | 2020-12-16 | MacroGenics, Inc. | BISPECIFIC BINDING MOLECULES CAPABLE OF BINDING TO CD137 AND TUMOR ANTIGENS, AND THEIR USES |
| EP3652209A2 (en) | 2017-07-11 | 2020-05-20 | Compass Therapeutics LLC | Agonist antibodies that bind human cd137 and uses thereof |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| CN111683968B (zh) * | 2017-11-13 | 2024-07-05 | 克雷森多生物制剂有限公司 | 结合至cd137和psma的分子 |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| CN111741976B (zh) | 2017-12-19 | 2024-09-17 | 英沃克斯制药有限公司 | 包括pd-l1抗原结合位点的fc结合片段 |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| CN112004535A (zh) | 2018-03-26 | 2020-11-27 | 4Sc股份公司 | 用于癌症疗法的包括hdac抑制剂和cd137激动剂的组合 |
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| CN112423845B (zh) | 2018-07-12 | 2024-07-30 | F-星治疗有限公司 | 结合pd-l1和cd137的抗体分子 |
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| AU2019315703A1 (en) * | 2018-07-31 | 2020-12-10 | Les Laboratoires Servier | Novel fusion protein specific for CD137 and PD-L1 |
| AU2019328632A1 (en) * | 2018-08-27 | 2021-03-25 | Pieris Pharmaceuticals Gmbh | Combination therapies comprising CD137/HER2 bispecific agents and PD-1 axis inhibitors and uses thereof |
| US12486330B2 (en) * | 2019-02-26 | 2025-12-02 | Pieris Pharmaceuticals Gmbh | Fusion proteins specific for CD137 and GPC3 |
| CN113939307A (zh) * | 2019-03-29 | 2022-01-14 | 皮里斯制药有限公司 | 脂质运载蛋白突变蛋白的吸入施用 |
| EP3952996A1 (en) * | 2019-04-12 | 2022-02-16 | F. Hoffmann-La Roche AG | Bispecific antigen binding molecules comprising lipocalin muteins |
| WO2021020846A1 (en) | 2019-07-26 | 2021-02-04 | Abl Bio Inc. | Anti-her2/anti-4-1bb bispecific antibody and use thereof |
| JP2023502876A (ja) * | 2019-11-04 | 2023-01-26 | ピエリス ファーマシューティカルズ ゲーエムベーハー | がんの治療のためのｈｅｒ２／４－１ｂｂ二重特異性融合タンパク質 |
| CN115151573A (zh) * | 2020-02-28 | 2022-10-04 | 上海复宏汉霖生物技术股份有限公司 | 抗cd137构建体、多特异性抗体及其用途 |
| KR20230042524A (ko) | 2020-08-07 | 2023-03-28 | 주식회사 유틸렉스 | 항-her2 / 항-4-1bb 이중특이적 항체 및 이의 용도 |
| EP4213946A1 (en) | 2020-09-18 | 2023-07-26 | Pieris Pharmaceuticals GmbH | Biomarker methods and uses |
| JP2024504388A (ja) * | 2021-01-25 | 2024-01-31 | ユーハン・コーポレイション | 抗４－１ｂｂ／抗ｈｅｒ２二重特異性抗体の精製方法 |
| CN117355319A (zh) | 2021-03-23 | 2024-01-05 | 皮里斯制药有限责任公司 | 用于癌症治疗的her2/4-1bb双特异性融合蛋白 |
| WO2022200478A1 (en) | 2021-03-24 | 2022-09-29 | Pieris Pharmaceuticals Gmbh | Tumor treatment with a 4-1bb/her2-bispecific agent and a her2-targeted tyrosine kinase inhibitor |
| CN117222672A (zh) | 2021-04-22 | 2023-12-12 | 安斯泰来制药株式会社 | 抗cldn4-抗cd137双特异性抗体 |
| WO2023180523A1 (en) | 2022-03-24 | 2023-09-28 | Pieris Pharmaceuticals Gmbh | Process for purifying fusion proteins |
| CN119894933A (zh) | 2022-09-20 | 2025-04-25 | 普米斯生物技术(珠海)有限公司 | 抗体及其在抗肿瘤中的应用 |
| TW202426503A (zh) * | 2022-10-19 | 2024-07-01 | 日商安斯泰來製藥股份有限公司 | 癌症治療中與ｐｄ－１訊息抑制劑組合之抗ｃｌｄｎ４－抗ｃｄ１３７雙特異性抗體的用途 |
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| IL300733B1 (en) * | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
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| DK2640740T3 (en) | 2010-11-15 | 2017-06-26 | Pieris Pharmaceuticals Gmbh | MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3) |
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| AU2015205530B8 (en) * | 2014-01-13 | 2019-09-19 | Pieris Pharmaceuticals Gmbh | Multi-specific polypeptide useful for localized tumor immunomodulation |
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| US11382963B2 (en) | 2015-01-12 | 2022-07-12 | Pieris Pharmaceuticals Gmbh | Engineered T cells and uses therefor |
| SG10201906859PA (en) | 2015-01-28 | 2019-08-27 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for angiogenesis |
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| CN107787327B (zh) | 2015-05-18 | 2022-02-08 | 皮里斯制药有限公司 | 对磷脂酰肌醇聚糖-3（gpc3）具有亲和力的人脂质运载蛋白2的突变蛋白 |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
-
2016
- 2016-05-04 CN CN201680025273.9A patent/CN107636014B/zh active Active
- 2016-05-04 CN CN202111366682.4A patent/CN114316067A/zh active Pending
- 2016-05-04 AU AU2016258977A patent/AU2016258977C1/en not_active Ceased
- 2016-05-04 SG SG11201708334RA patent/SG11201708334RA/en unknown
- 2016-05-04 RU RU2017135596A patent/RU2727165C2/ru active
- 2016-05-04 BR BR112017020434A patent/BR112017020434A2/pt not_active Application Discontinuation
- 2016-05-04 EP EP24151494.2A patent/EP4378962A3/en not_active Withdrawn
- 2016-05-04 KR KR1020177034820A patent/KR20170138574A/ko active Pending
- 2016-05-04 JP JP2017557310A patent/JP6783797B2/ja not_active Expired - Fee Related
- 2016-05-04 US US15/571,561 patent/US10865250B2/en active Active
- 2016-05-04 EP EP16721154.9A patent/EP3292148B1/en active Active
- 2016-05-04 MX MX2017014083A patent/MX2017014083A/es unknown
- 2016-05-04 WO PCT/EP2016/060041 patent/WO2016177802A1/en not_active Ceased
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2017
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2020
- 2020-11-12 US US17/096,750 patent/US20210198380A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156456A1 (en) * | 2008-06-24 | 2009-12-30 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| RU2636342C2 (ru) * | 2012-04-30 | 2017-11-22 | Биокон Лимитед | Нацеленные/иммуномодулирующие слитые белки и способы их получения |
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| ZA201705961B (en) | 2023-12-20 |
| CN114316067A (zh) | 2022-04-12 |
| CN107636014B (zh) | 2021-12-07 |
| AU2016258977A1 (en) | 2017-11-30 |
| US20210198380A1 (en) | 2021-07-01 |
| CN107636014A (zh) | 2018-01-26 |
| US10865250B2 (en) | 2020-12-15 |
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| RU2017135596A3 (enExample) | 2019-09-16 |
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| EP3292148B1 (en) | 2024-01-24 |
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| RU2017135596A (ru) | 2019-06-04 |
| JP6783797B2 (ja) | 2020-11-11 |
| SG11201708334RA (en) | 2017-11-29 |
| EP3292148A1 (en) | 2018-03-14 |
| BR112017020434A2 (pt) | 2018-06-26 |
| KR20170138574A (ko) | 2017-12-15 |
| MX2017014083A (es) | 2018-11-09 |
| CA2980840A1 (en) | 2016-11-10 |
| WO2016177802A1 (en) | 2016-11-10 |
| AU2016258977C1 (en) | 2022-07-14 |
| AU2016258977B2 (en) | 2022-03-17 |
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