KR20170138574A - 항암 융합 폴리펩타이드 - Google Patents

항암 융합 폴리펩타이드 Download PDF

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KR20170138574A
KR20170138574A KR1020177034820A KR20177034820A KR20170138574A KR 20170138574 A KR20170138574 A KR 20170138574A KR 1020177034820 A KR1020177034820 A KR 1020177034820A KR 20177034820 A KR20177034820 A KR 20177034820A KR 20170138574 A KR20170138574 A KR 20170138574A
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glu
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말론 히너
크리스틴 로테
쉐인 올윌
라시다 시함 벨 아이바
울리히 뫼비우스
코리나 슐로서
토마스 진 호아킨
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피어이스 파마슈티컬즈 게엠베하
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Publication of KR20170138574A publication Critical patent/KR20170138574A/ko
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020177034820A 2015-05-04 2016-05-04 항암 융합 폴리펩타이드 Pending KR20170138574A (ko)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
EP15166179.0 2015-05-04
EP15166179 2015-05-04
EP15167917.2 2015-05-18
EP15167917 2015-05-18
EP15002702.7 2015-09-17
EP15002702 2015-09-17
EP15192870 2015-11-04
EP15192870.2 2015-11-04
EP16150705.8 2016-01-11
EP16150705 2016-01-11
EP16000862.9 2016-04-15
EP16000862 2016-04-15
PCT/EP2016/060041 WO2016177802A1 (en) 2015-05-04 2016-05-04 Anti-cancer fusion polypeptide

Publications (1)

Publication Number Publication Date
KR20170138574A true KR20170138574A (ko) 2017-12-15

Family

ID=55948826

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177034820A Pending KR20170138574A (ko) 2015-05-04 2016-05-04 항암 융합 폴리펩타이드

Country Status (13)

Country Link
US (2) US10865250B2 (enExample)
EP (2) EP4378962A3 (enExample)
JP (1) JP6783797B2 (enExample)
KR (1) KR20170138574A (enExample)
CN (2) CN107636014B (enExample)
AU (1) AU2016258977C1 (enExample)
BR (1) BR112017020434A2 (enExample)
CA (1) CA2980840A1 (enExample)
MX (1) MX2017014083A (enExample)
RU (1) RU2727165C2 (enExample)
SG (1) SG11201708334RA (enExample)
WO (1) WO2016177802A1 (enExample)
ZA (1) ZA201705961B (enExample)

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CN115151573A (zh) * 2020-02-28 2022-10-04 上海复宏汉霖生物技术股份有限公司 抗cd137构建体、多特异性抗体及其用途
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ZA201705961B (en) 2023-12-20
CN114316067A (zh) 2022-04-12
CN107636014B (zh) 2021-12-07
AU2016258977A1 (en) 2017-11-30
US20210198380A1 (en) 2021-07-01
CN107636014A (zh) 2018-01-26
US10865250B2 (en) 2020-12-15
EP4378962A2 (en) 2024-06-05
RU2017135596A3 (enExample) 2019-09-16
JP2018515085A (ja) 2018-06-14
EP3292148B1 (en) 2024-01-24
EP4378962A3 (en) 2024-07-31
HK1249526A1 (en) 2018-11-02
US20190010248A1 (en) 2019-01-10
RU2017135596A (ru) 2019-06-04
JP6783797B2 (ja) 2020-11-11
SG11201708334RA (en) 2017-11-29
EP3292148A1 (en) 2018-03-14
BR112017020434A2 (pt) 2018-06-26
MX2017014083A (es) 2018-11-09
CA2980840A1 (en) 2016-11-10
WO2016177802A1 (en) 2016-11-10
AU2016258977C1 (en) 2022-07-14
AU2016258977B2 (en) 2022-03-17
RU2727165C2 (ru) 2020-07-21

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