JP2018515084A5 - - Google Patents
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- JP2018515084A5 JP2018515084A5 JP2017557299A JP2017557299A JP2018515084A5 JP 2018515084 A5 JP2018515084 A5 JP 2018515084A5 JP 2017557299 A JP2017557299 A JP 2017557299A JP 2017557299 A JP2017557299 A JP 2017557299A JP 2018515084 A5 JP2018515084 A5 JP 2018515084A5
- Authority
- JP
- Japan
- Prior art keywords
- ser
- lys
- asp
- arg
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000019298 Lipocalin Human genes 0.000 claims description 23
- 108050006654 Lipocalin Proteins 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 11
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 4
- 101000946124 Homo sapiens Lipocalin-1 Proteins 0.000 claims description 4
- 108010002350 Interleukin-2 Proteins 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000013642 negative control Substances 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 3
- 102000014914 Carrier Proteins Human genes 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 claims description 2
- 108010012236 Chemokines Proteins 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 108091008324 binding proteins Proteins 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000032823 cell division Effects 0.000 claims description 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims description 2
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims description 2
- 230000007783 downstream signaling Effects 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 238000010353 genetic engineering Methods 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000002739 metals Chemical class 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 230000000770 proinflammatory effect Effects 0.000 claims description 2
- 108020001580 protein domains Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 101001023833 Homo sapiens Neutrophil gelatinase-associated lipocalin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 102000047202 human LCN2 Human genes 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 8
- 238000003556 assay Methods 0.000 description 5
- 102000000588 Interleukin-2 Human genes 0.000 description 3
- 230000006044 T cell activation Effects 0.000 description 3
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021036823A JP7149363B2 (ja) | 2015-05-04 | 2021-03-09 | Ｃｄ１３７に特異的なタンパク質 |
| JP2022152103A JP7477905B2 (ja) | 2015-05-04 | 2022-09-26 | Ｃｄ１３７に特異的なタンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15166184.0 | 2015-05-04 | ||
| EP15166184 | 2015-05-04 | ||
| PCT/EP2016/059959 WO2016177762A1 (en) | 2015-05-04 | 2016-05-04 | Proteins specific for cd137 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036823A Division JP7149363B2 (ja) | 2015-05-04 | 2021-03-09 | Ｃｄ１３７に特異的なタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515084A JP2018515084A (ja) | 2018-06-14 |
| JP2018515084A5 true JP2018515084A5 (enExample) | 2019-06-06 |
| JP6884708B2 JP6884708B2 (ja) | 2021-06-09 |
Family
ID=53054879
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557299A Active JP6884708B2 (ja) | 2015-05-04 | 2016-05-04 | Ｃｄ１３７に特異的なタンパク質 |
| JP2021036823A Active JP7149363B2 (ja) | 2015-05-04 | 2021-03-09 | Ｃｄ１３７に特異的なタンパク質 |
| JP2022152103A Active JP7477905B2 (ja) | 2015-05-04 | 2022-09-26 | Ｃｄ１３７に特異的なタンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036823A Active JP7149363B2 (ja) | 2015-05-04 | 2021-03-09 | Ｃｄ１３７に特異的なタンパク質 |
| JP2022152103A Active JP7477905B2 (ja) | 2015-05-04 | 2022-09-26 | Ｃｄ１３７に特異的なタンパク質 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11261221B2 (enExample) |
| EP (2) | EP4177262A1 (enExample) |
| JP (3) | JP6884708B2 (enExample) |
| KR (1) | KR102734408B1 (enExample) |
| CN (2) | CN114573680A (enExample) |
| AU (1) | AU2016258952C1 (enExample) |
| CA (1) | CA2980839C (enExample) |
| CL (1) | CL2017002767A1 (enExample) |
| DK (1) | DK3292137T3 (enExample) |
| ES (1) | ES2932425T3 (enExample) |
| IL (1) | IL254516B (enExample) |
| MX (1) | MX2017014082A (enExample) |
| NZ (1) | NZ736560A (enExample) |
| PH (1) | PH12017501583B1 (enExample) |
| RU (1) | RU2736312C2 (enExample) |
| SG (1) | SG11201708339QA (enExample) |
| WO (1) | WO2016177762A1 (enExample) |
| ZA (1) | ZA201705960B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2564125C2 (ru) | 2009-12-07 | 2015-09-27 | Пирис Аг | Мутеины липокалина 2 человека (lcn2, hngal) с аффинностью для определенной мишени |
| CA2891557A1 (en) | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| SG10201912019WA (en) | 2014-05-22 | 2020-02-27 | Pieris Pharmaceuticals Gmbh | Novel specific-binding polypeptides and uses thereof |
| CA2973640A1 (en) | 2015-01-28 | 2016-08-04 | Rachida Siham Bel Aiba | Novel proteins specific for angiogenesis |
| EP4177262A1 (en) | 2015-05-04 | 2023-05-10 | Pieris Pharmaceuticals GmbH | Proteins specific for cd137 |
| EP3292148B1 (en) | 2015-05-04 | 2024-01-24 | Pieris Pharmaceuticals GmbH | Anti-cancer fusion polypeptide |
| JP6947642B2 (ja) | 2015-05-18 | 2021-10-13 | ピエリス ファーマシューティカルズ ゲーエムベーハー | 抗がん性融合ポリペプチド |
| RU2756318C2 (ru) | 2015-05-18 | 2021-09-29 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) |
| SG10201911499TA (en) | 2015-11-30 | 2020-01-30 | Pieris Australia Pty Ltd | Novel anti-angiogenic fusion polypeptides |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
| WO2018087108A1 (en) * | 2016-11-09 | 2018-05-17 | Pieris Pharmaceuticals Gmbh | Proteins specific for cd137 |
| US12285410B2 (en) | 2018-03-26 | 2025-04-29 | 4Sc Ag | Combination comprising HDAC inhibitor and CD137 agonist for cancer therapy |
| JP7651450B2 (ja) | 2018-07-24 | 2025-03-26 | インヒブルクス バイオサイエンシズ インコーポレイテッド | 制約されたｃｄ３結合ドメインおよび受容体結合領域を含有する多重特異性ポリペプチド構築物ならびにそれを使用する方法 |
| AU2019315703A1 (en) * | 2018-07-31 | 2020-12-10 | Les Laboratoires Servier | Novel fusion protein specific for CD137 and PD-L1 |
| CA3115089A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| CA3115285A1 (en) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Pd-1 single domain antibodies and therapeutic compositions thereof |
| EP3931209A1 (en) * | 2019-02-26 | 2022-01-05 | Pieris Pharmaceuticals GmbH | Novel fusion proteins specific for cd137 and gpc3 |
| CN113939307A (zh) | 2019-03-29 | 2022-01-14 | 皮里斯制药有限公司 | 脂质运载蛋白突变蛋白的吸入施用 |
| EP3952996A1 (en) | 2019-04-12 | 2022-02-16 | F. Hoffmann-La Roche AG | Bispecific antigen binding molecules comprising lipocalin muteins |
| KR20220097952A (ko) | 2019-11-04 | 2022-07-08 | 피어이스 파마슈티컬즈 게엠베하 | 암 치료를 위한 her2/4-1bb 이중특이적 융합 단백질 |
| CA3177098A1 (en) | 2020-06-05 | 2021-12-09 | Pieris Pharmaceuticals Gmbh | Multimeric immunomodulator targeting 4-1bb |
| US20230366884A1 (en) | 2020-09-18 | 2023-11-16 | Pieris Pharmaceuticals Gmbh | Biomarker methods and uses |
| WO2022200412A2 (en) | 2021-03-23 | 2022-09-29 | Pieris Pharmaceuticals Gmbh | Her2/4-1bb bispecific fusion proteins for the treatment of cancer |
| WO2022200478A1 (en) | 2021-03-24 | 2022-09-29 | Pieris Pharmaceuticals Gmbh | Tumor treatment with a 4-1bb/her2-bispecific agent and a her2-targeted tyrosine kinase inhibitor |
| WO2023118497A1 (en) | 2021-12-22 | 2023-06-29 | Pieris Pharmaceuticals Gmbh | Novel il-18 variants |
| WO2023180523A1 (en) | 2022-03-24 | 2023-09-28 | Pieris Pharmaceuticals Gmbh | Process for purifying fusion proteins |
| EP4590695A1 (en) | 2022-09-21 | 2025-07-30 | Seagen Inc. | Novel fusion protein specific for cd137 and cd228 |
| WO2025175123A1 (en) | 2024-02-16 | 2025-08-21 | Seagen Inc. | Methods of treating cancer using fusion proteins specific for cd137 and cd228 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3779221D1 (de) | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| JPH10500672A (ja) | 1994-05-18 | 1998-01-20 | インヘイル セラピューティック システムズ，インコーポレイティド | インターフェロンの乾燥粉末製剤に関する方法及び組成物 |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998016873A1 (en) | 1996-10-14 | 1998-04-23 | Firm Forsat Ltd. | Method for preparing dispersions of chromogenic components |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| HRP20000808A2 (en) | 1998-06-08 | 2001-10-31 | Hoffmann La Roche | Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| EP1377306A1 (en) | 2001-03-09 | 2004-01-07 | Dyax Corp. | Serum albumin binding moieties |
| AU2001298053A1 (en) | 2001-09-27 | 2003-04-14 | Pieris Proteolab Ag | Muteins of apolipoprotein D |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| JP2007284351A (ja) | 2004-07-27 | 2007-11-01 | Osaka Bioscience Institute | アミロイド蛋白質の凝集を抑制する物質とその作用 |
| EP2899277A1 (en) | 2004-11-26 | 2015-07-29 | Pieris AG | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| WO2007038619A2 (en) | 2005-09-27 | 2007-04-05 | Amunix, Inc. | Proteinaceous pharmaceuticals and uses thereof |
| ES2354653T3 (es) * | 2006-08-01 | 2011-03-16 | Pieris Ag | Muteínas de lipocalina lacrimal y procedimientos para obtener las mismas. |
| DK2046820T3 (da) | 2006-08-01 | 2011-02-07 | Pieris Ag | Muteiner af tåre-lipocalin og fremgangsmåder til opnåelse deraf |
| WO2009052392A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| CA2729322C (en) | 2008-06-24 | 2020-05-26 | Technische Universitaet Muenchen | Muteins of hngal and related proteins with affinity for a given target |
| RU2564125C2 (ru) * | 2009-12-07 | 2015-09-27 | Пирис Аг | Мутеины липокалина 2 человека (lcn2, hngal) с аффинностью для определенной мишени |
| DK2606061T3 (da) * | 2010-08-16 | 2017-11-06 | Pieris Pharmaceuticals Gmbh | Bindingsproteiner til hepcidin |
| US9260492B2 (en) | 2010-11-15 | 2016-02-16 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3) |
| CA2905186A1 (en) | 2013-03-14 | 2014-09-18 | Daiichi Sankyo Co., Ltd | Novel binding proteins for pcsk9 |
| CA2891557A1 (en) * | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| CA2973640A1 (en) | 2015-01-28 | 2016-08-04 | Rachida Siham Bel Aiba | Novel proteins specific for angiogenesis |
| WO2016131804A1 (en) | 2015-02-18 | 2016-08-25 | Sanofi | Novel proteins specific for pyoverdine and pyochelin |
| EP4177262A1 (en) | 2015-05-04 | 2023-05-10 | Pieris Pharmaceuticals GmbH | Proteins specific for cd137 |
| EP3292148B1 (en) | 2015-05-04 | 2024-01-24 | Pieris Pharmaceuticals GmbH | Anti-cancer fusion polypeptide |
| JP6947642B2 (ja) * | 2015-05-18 | 2021-10-13 | ピエリス ファーマシューティカルズ ゲーエムベーハー | 抗がん性融合ポリペプチド |
| RU2756318C2 (ru) | 2015-05-18 | 2021-09-29 | ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ | Мутеины липокалина 2 человека с аффинностью в отношении глипикана-3 (gpc3) |
| WO2018087108A1 (en) | 2016-11-09 | 2018-05-17 | Pieris Pharmaceuticals Gmbh | Proteins specific for cd137 |
-
2016
- 2016-05-04 EP EP22193830.1A patent/EP4177262A1/en active Pending
- 2016-05-04 RU RU2017135599A patent/RU2736312C2/ru active
- 2016-05-04 WO PCT/EP2016/059959 patent/WO2016177762A1/en not_active Ceased
- 2016-05-04 US US15/571,611 patent/US11261221B2/en active Active
- 2016-05-04 AU AU2016258952A patent/AU2016258952C1/en active Active
- 2016-05-04 SG SG11201708339QA patent/SG11201708339QA/en unknown
- 2016-05-04 CN CN202210118268.XA patent/CN114573680A/zh active Pending
- 2016-05-04 MX MX2017014082A patent/MX2017014082A/es unknown
- 2016-05-04 PH PH1/2017/501583A patent/PH12017501583B1/en unknown
- 2016-05-04 DK DK16721149.9T patent/DK3292137T3/da active
- 2016-05-04 JP JP2017557299A patent/JP6884708B2/ja active Active
- 2016-05-04 NZ NZ736560A patent/NZ736560A/en unknown
- 2016-05-04 KR KR1020177034948A patent/KR102734408B1/ko active Active
- 2016-05-04 EP EP16721149.9A patent/EP3292137B1/en active Active
- 2016-05-04 CA CA2980839A patent/CA2980839C/en active Active
- 2016-05-04 CN CN201680025274.3A patent/CN107820500B/zh active Active
- 2016-05-04 ES ES16721149T patent/ES2932425T3/es active Active
-
2017
- 2017-09-01 ZA ZA2017/05960A patent/ZA201705960B/en unknown
- 2017-09-14 IL IL254516A patent/IL254516B/en unknown
- 2017-11-02 CL CL2017002767A patent/CL2017002767A1/es unknown
-
2021
- 2021-03-09 JP JP2021036823A patent/JP7149363B2/ja active Active
-
2022
- 2022-01-19 US US17/579,392 patent/US12195503B2/en active Active
- 2022-09-26 JP JP2022152103A patent/JP7477905B2/ja active Active
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