JP2014502149A5 - - Google Patents
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- Publication number
- JP2014502149A5 JP2014502149A5 JP2013538232A JP2013538232A JP2014502149A5 JP 2014502149 A5 JP2014502149 A5 JP 2014502149A5 JP 2013538232 A JP2013538232 A JP 2013538232A JP 2013538232 A JP2013538232 A JP 2013538232A JP 2014502149 A5 JP2014502149 A5 JP 2014502149A5
- Authority
- JP
- Japan
- Prior art keywords
- arg
- mutein
- gly
- trp
- asn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102000010956 Glypican Human genes 0.000 claims 5
- 108050001154 Glypican Proteins 0.000 claims 5
- 108050007237 Glypican-3 Proteins 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102000008300 Mutant Proteins Human genes 0.000 claims 3
- 108010021466 Mutant Proteins Proteins 0.000 claims 3
- 150000001875 compounds Chemical group 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical class N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 239000002184 metal Chemical class 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000013519 Lipocalin-2 Human genes 0.000 claims 1
- 108010051335 Lipocalin-2 Proteins 0.000 claims 1
- QTZXSYBVOSXBEJ-WDSKDSINSA-N Met-Asp Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O QTZXSYBVOSXBEJ-WDSKDSINSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000011616 biotin Chemical class 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000000824 cytostatic agent Chemical class 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical class C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001515 polyalkylene glycol Polymers 0.000 claims 1
- 108020001580 protein domains Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 239000003053 toxin Chemical class 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41370610P | 2010-11-15 | 2010-11-15 | |
| EP10191228.5 | 2010-11-15 | ||
| EP10191228 | 2010-11-15 | ||
| US61/413,706 | 2010-11-15 | ||
| PCT/EP2011/070119 WO2012065978A1 (en) | 2010-11-15 | 2011-11-15 | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502149A JP2014502149A (ja) | 2014-01-30 |
| JP2014502149A5 true JP2014502149A5 (enExample) | 2015-01-08 |
| JP6100694B2 JP6100694B2 (ja) | 2017-03-22 |
Family
ID=45346426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538232A Expired - Fee Related JP6100694B2 (ja) | 2010-11-15 | 2011-11-15 | グリピカン−３（ｇｐｃ３）に対して親和性を有するヒトリポカリン２の突然変異タンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9260492B2 (enExample) |
| EP (1) | EP2640740B1 (enExample) |
| JP (1) | JP6100694B2 (enExample) |
| AU (1) | AU2011331232B2 (enExample) |
| CA (1) | CA2817779C (enExample) |
| DK (1) | DK2640740T3 (enExample) |
| WO (1) | WO2012065978A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2990798B1 (en) * | 2009-12-07 | 2019-09-25 | Pieris Pharmaceuticals GmbH | Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target |
| CA2817779C (en) | 2010-11-15 | 2019-02-19 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
| WO2013174783A1 (en) * | 2012-05-23 | 2013-11-28 | Pieris Ag | Lipocalin muteins with binding-affinity for glypican-3 (gpc-3) and use of lipocalin muteins for target-specific delivery to cells expressing gpc-3 |
| CA2891557A1 (en) | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| AU2015261968B2 (en) | 2014-05-22 | 2018-11-22 | Pieris Pharmaceuticals Gmbh | Novel specific-binding polypeptides and uses thereof |
| EP3245288A1 (en) * | 2015-01-12 | 2017-11-22 | Pieris Pharmaceuticals GmbH | Engineered t cells and uses therefor |
| MX384075B (es) | 2015-01-28 | 2025-03-14 | Pieris Pharmaceuticals Gmbh | Nuevas proteínas específicas para la angiogénesis. |
| CN114316067A (zh) | 2015-05-04 | 2022-04-12 | 皮里斯制药有限公司 | 抗癌融合多肽 |
| ES2932425T3 (es) | 2015-05-04 | 2023-01-19 | Pieris Pharmaceuticals Gmbh | Proteínas específicas para CD137 |
| MX390894B (es) | 2015-05-18 | 2025-03-21 | Pieris Pharmaceuticals Gmbh | Polipéptido de fusión anti-cáncer. |
| BR112017020961A2 (pt) * | 2015-05-18 | 2018-07-10 | Pieris Pharmaceuticals Gmbh | muteína, molécula de ácido nucleico, célula hospedeira, método de produção de uma muteína e método de ligação |
| EP3115066A1 (en) | 2015-07-07 | 2017-01-11 | Technische Universität München | Novel psma-specific binding proteins |
| CN108884147B (zh) * | 2015-09-23 | 2024-02-27 | 百时美施贵宝公司 | 结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子 |
| SG10201911499TA (en) | 2015-11-30 | 2020-01-30 | Pieris Australia Pty Ltd | Novel anti-angiogenic fusion polypeptides |
| TW201725212A (zh) | 2015-12-10 | 2017-07-16 | 第一三共股份有限公司 | 特異性於降鈣素基因相關胜肽的新穎蛋白 |
| ES3015117T3 (en) | 2016-08-29 | 2025-04-29 | Fred Hutchinson Cancer Center | Chelating platform for delivery of radionuclides |
| EP3502130A1 (en) | 2017-12-20 | 2019-06-26 | St. Anna Kinderkrebsforschung | Ligand regulated protein-protein interaction system |
| JP2021506329A (ja) | 2017-12-20 | 2021-02-22 | ザンクト アンナ キンダークレプスフォルシュング | リガンド制御したタンパク質−タンパク質相互作用システム |
| MA53982A (fr) | 2018-10-23 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines hétérodimères fusionnées à un fragment fc |
| AU2020253034A1 (en) | 2019-03-29 | 2021-08-19 | Pieris Pharmaceuticals Gmbh | Inhaled administration of lipocalin muteins |
| JP7644777B2 (ja) | 2020-04-22 | 2025-03-12 | ドラゴンフライ セラピューティクス， インコーポレイテッド | ヘテロ二量体Ｆｃ融合タンパク質のための製剤、投薬量レジメン、及び製造工程 |
| KR20230020443A (ko) | 2020-06-05 | 2023-02-10 | 피어이스 파마슈티컬즈 게엠베하 | 4-1bb 표적화 다량체 면역조절제 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| DK1087778T3 (da) | 1998-06-08 | 2005-12-19 | Hoffmann La Roche | Anvendelse af PEG-IFN-alfa og Ribavirin til behandling af kronisk hepatitis C |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| US7235520B2 (en) * | 2000-09-21 | 2007-06-26 | University Of Massachusetts | Method of inducing apoptosis in lymphoid cells |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US7118915B2 (en) | 2001-09-27 | 2006-10-10 | Pieris Proteolab Ag | Muteins of apolipoprotein D |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| WO2005019254A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| US7892827B2 (en) * | 2004-11-26 | 2011-02-22 | Pieris Ag | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| US20070191272A1 (en) | 2005-09-27 | 2007-08-16 | Stemmer Willem P | Proteinaceous pharmaceuticals and uses thereof |
| US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
| WO2007137170A2 (en) | 2006-05-20 | 2007-11-29 | Seattle Genetics, Inc. | Anti-glypican-3 antibody drug conjugates |
| AU2008275985B2 (en) | 2007-07-17 | 2013-09-19 | E. R. Squibb & Sons, L.L.C. | Monoclonal antibodies against Glypican-3 |
| EP2313430B1 (en) * | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| CA2817779C (en) | 2010-11-15 | 2019-02-19 | Pieris Ag | Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3) |
-
2011
- 2011-11-15 CA CA2817779A patent/CA2817779C/en active Active
- 2011-11-15 DK DK11794661.6T patent/DK2640740T3/en active
- 2011-11-15 EP EP11794661.6A patent/EP2640740B1/en active Active
- 2011-11-15 AU AU2011331232A patent/AU2011331232B2/en not_active Ceased
- 2011-11-15 US US13/885,229 patent/US9260492B2/en active Active
- 2011-11-15 JP JP2013538232A patent/JP6100694B2/ja not_active Expired - Fee Related
- 2011-11-15 WO PCT/EP2011/070119 patent/WO2012065978A1/en not_active Ceased
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