JP2017527310A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017527310A5 JP2017527310A5 JP2017533170A JP2017533170A JP2017527310A5 JP 2017527310 A5 JP2017527310 A5 JP 2017527310A5 JP 2017533170 A JP2017533170 A JP 2017533170A JP 2017533170 A JP2017533170 A JP 2017533170A JP 2017527310 A5 JP2017527310 A5 JP 2017527310A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric receptor
- domain
- pharmaceutical composition
- receptor
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700010039 chimeric receptor Proteins 0.000 claims 22
- 210000002865 immune cell Anatomy 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 8
- 230000011664 signaling Effects 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 7
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 5
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 5
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 5
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 5
- 230000000139 costimulatory effect Effects 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000001086 cytosolic effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 108020001756 ligand binding domains Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000003979 eosinophil Anatomy 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 210000002540 macrophage Anatomy 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- -1 CD3ζ Proteins 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 1
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims 1
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 1
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims 1
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 108010073816 IgE Receptors Proteins 0.000 claims 1
- 102000009438 IgE Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 101100341510 Mus musculus Itgal gene Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000548 alemtuzumab Drugs 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960003270 belimumab Drugs 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960000455 brentuximab vedotin Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 229960001838 canakinumab Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960003115 certolizumab pegol Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 230000004940 costimulation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000003389 potentiating effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229960001612 trastuzumab emtansine Drugs 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047916P | 2014-09-09 | 2014-09-09 | |
| US62/047,916 | 2014-09-09 | ||
| PCT/US2015/049126 WO2016040441A1 (en) | 2014-09-09 | 2015-09-09 | Chimeric receptors and uses thereof in immune therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527310A JP2017527310A (ja) | 2017-09-21 |
| JP2017527310A5 true JP2017527310A5 (enExample) | 2018-10-18 |
Family
ID=54151414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533170A Pending JP2017527310A (ja) | 2014-09-09 | 2015-09-09 | キメラ受容体および免疫療法におけるその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20180133252A9 (enExample) |
| EP (1) | EP3191507A1 (enExample) |
| JP (1) | JP2017527310A (enExample) |
| KR (1) | KR20170073593A (enExample) |
| CN (1) | CN107074969A (enExample) |
| AU (1) | AU2015315199B2 (enExample) |
| BR (1) | BR112017004675A2 (enExample) |
| CA (1) | CA2972714A1 (enExample) |
| IL (1) | IL250828A0 (enExample) |
| MA (1) | MA40595A (enExample) |
| MX (1) | MX2017003062A (enExample) |
| SG (2) | SG11201701775VA (enExample) |
| WO (1) | WO2016040441A1 (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013112871A1 (en) | 2012-01-27 | 2013-08-01 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic il-13 polypeptides |
| US9738696B2 (en) | 2012-08-09 | 2017-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities |
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| AU2014337195B2 (en) * | 2013-10-17 | 2018-11-08 | National University Of Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
| SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| EP3430036A4 (en) * | 2016-03-18 | 2019-08-14 | Unum Therapeutics | MODIFIED CHIMERIC RECEPTORS AND USES IN IMMUNOTHERAPY |
| WO2017205254A1 (en) * | 2016-05-23 | 2017-11-30 | Unum Therapeutics | Immune cells expressing antibody-coupled t-cell receptor (actr) for use in inhibiting cancer cells expressing surface immunoglobulin |
| WO2018017649A1 (en) * | 2016-07-19 | 2018-01-25 | Unum Therapeutics Inc. | Use of antibody-coupled t cell receptor (actr) with multiple anti-cancer antibodies in cancer treatment |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| CA3036745A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| KR20250072712A (ko) | 2016-12-02 | 2025-05-26 | 앤젤레스 테라퓨틱스, 인코포레이티드 | 합성 면역 수용체 및 이의 사용 방법 |
| US20200095301A1 (en) * | 2016-12-14 | 2020-03-26 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
| US11578115B2 (en) | 2017-01-10 | 2023-02-14 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
| JP2020506697A (ja) * | 2017-01-30 | 2020-03-05 | ユーナム・セラピューティクス・インコーポレイテッドＵｎｕｍ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 改善された抗体結合ｔ細胞受容体構築物およびその治療用途 |
| US20190381171A1 (en) * | 2017-02-17 | 2019-12-19 | Unum Therapeutics Inc. | Co-use of anti-bcma antibody and antibody-coupled t cell receptor (actr) in cancer therapy and b cell disorders |
| AU2018236450A1 (en) * | 2017-03-16 | 2019-10-03 | The General Hospital Corporation | Chimeric antigen receptors targeting CD37 |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| KR102712254B1 (ko) | 2017-03-27 | 2024-10-04 | 에프. 호프만-라 로슈 아게 | 개선된 항원 결합 수용체 |
| CN110636851B (zh) | 2017-03-27 | 2023-11-03 | 新加坡国立大学 | 截短的nkg2d嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| RU2019133199A (ru) * | 2017-03-27 | 2021-04-28 | Ф. Хоффманн-Ля Рош Аг | Улучшенные форматы антигенсвязывающего рецептора |
| MX2019014584A (es) | 2017-06-07 | 2020-02-07 | Seattle Genetics Inc | Celulas t con fucosilacion de superficie reducida y metodos para preparar y usar las mismas. |
| CA3072908A1 (en) * | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | Strep-tag specific binding proteins and uses thereof |
| EP3694558B1 (en) | 2017-10-10 | 2024-04-10 | Medicenna Therapeutics Inc. | Il-4-fusion formulations for treatment of central nervous system (cns) tumors |
| EP3700542A4 (en) * | 2017-10-26 | 2020-12-09 | Regents of the University of Minnesota | RECOMBINANT IMMUNE CELLS, METHODS OF MANUFACTURING AND METHODS OF USE |
| CN111295189B (zh) * | 2017-11-01 | 2023-09-15 | 艾洛基治疗公司 | 修饰的胱天蛋白酶-9多肽及其使用方法 |
| SG11202004003YA (en) * | 2017-11-09 | 2020-05-28 | Sangamo Therapeutics Inc | Genetic modification of cytokine inducible sh2-containing protein (cish) gene |
| EP3707160A1 (en) | 2017-11-10 | 2020-09-16 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Chimeric antigen receptors targeting tumor antigens |
| KR20250067182A (ko) | 2017-11-10 | 2025-05-14 | 주라 바이오, 인크. | 주 조직적합성 복합체-기반 키메라 수용체 및 자가면역 질병을 치료하기 위한 이의 용도 |
| BR112020012336A2 (pt) * | 2017-12-19 | 2021-03-30 | Akouos, Inc. | Administração de anticorpos terapêuticos mediada por aav para o ouvido interno |
| CN109970864A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 一种双向激活共刺激分子受体及其用途 |
| CN111770937A (zh) * | 2017-12-29 | 2020-10-13 | 希望之城 | 中间位使能t细胞 |
| CA3089170A1 (en) | 2018-02-09 | 2019-08-15 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| WO2019179871A1 (en) * | 2018-03-19 | 2019-09-26 | Svar Life Science Ab | SYSTEM AND PRODUCTS FOR IMPROVED QUANTIFICATION OF ADCC and ADCP ACTIVITY |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| IL321548A (en) * | 2018-05-22 | 2025-08-01 | Immunitybio Inc | Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof |
| CA3104862A1 (en) | 2018-07-03 | 2020-01-09 | Sotio, LLC | Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof |
| SG11202101284UA (en) | 2018-08-14 | 2021-03-30 | Sotio Llc | Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| WO2020068702A1 (en) * | 2018-09-24 | 2020-04-02 | Fred Hutchinson Cancer Research Center | Chimeric receptor proteins and uses thereof |
| WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| AU2020243623A1 (en) * | 2019-03-19 | 2021-11-04 | Ramot At Tel-Aviv University Ltd. | T cell expressing an FC gamma receptor and methods of use thereof |
| EP3957325A4 (en) | 2019-04-19 | 2023-01-04 | Chugai Seiyaku Kabushiki Kaisha | CHEMERA RECEPTOR RECOGNIZING AN ANTIBODY MODIFICATION SITE |
| US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| MX2022002613A (es) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Metodos y composiciones para la integracion del genoma. |
| CN111944062B (zh) * | 2019-12-09 | 2023-11-07 | 深圳市体内生物医药科技有限公司 | 一种识别Fc片段的嵌合抗原受体及其应用 |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| CN111100942B (zh) * | 2019-12-31 | 2023-03-28 | 海南波莲水稻基因科技有限公司 | 与水稻光温敏核雄性不育表型相关的分子标记和应用 |
| EP4105240A4 (en) * | 2020-02-13 | 2024-05-29 | Sichuan University | Chimeric antigen receptor and use thereof |
| EP3875478A1 (en) * | 2020-03-05 | 2021-09-08 | Canvax Biotech, S.L. | Novel non-immunogenic chimeric antigen receptors and uses thereof |
| EP4168438A4 (en) | 2020-06-22 | 2024-07-10 | Ramot at Tel-Aviv University Ltd. | Multi subunit protein modules, cells expressing same and uses thereof |
| CN113583139A (zh) * | 2020-07-06 | 2021-11-02 | 上海鑫湾生物科技有限公司 | 一种嵌合受体及其应用 |
| CA3190649A1 (en) | 2020-07-31 | 2022-02-03 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising cell expressing chimeric receptor |
| CN111876382A (zh) * | 2020-08-14 | 2020-11-03 | 上海星华生物医药科技有限公司 | 一种制备通用型免疫细胞的方法及其应用 |
| US20230302132A1 (en) * | 2020-08-14 | 2023-09-28 | Shanghai Xinghua Bio Pharmaceutical Science & Technology Co., Ltd | Method for preparing universal immune cells and use thereof |
| AU2021376354A1 (en) | 2020-11-04 | 2023-06-22 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
| AU2021391433A1 (en) | 2020-12-01 | 2023-06-22 | Akouos, Inc. | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| KR20230123515A (ko) * | 2020-12-22 | 2023-08-23 | 이뮤니티바이오, 인크. | Fc-수용체 car 작제물 및 세포 (fc-receptor car constructsand cells) |
| WO2022150379A1 (en) * | 2021-01-08 | 2022-07-14 | Regents Of The University Of Minnesota | Nk cell engager molecules and methods of use |
| AU2022237618A1 (en) | 2021-03-17 | 2023-10-12 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
| CA3218780A1 (en) | 2021-05-11 | 2022-11-17 | Daniel Getts | Methods and compositions for genomic integration |
| CA3232833A1 (en) | 2021-09-27 | 2023-03-30 | Kathleen Mcginness | Chimeric receptor polypeptides in combination with trans metabolism molecules that re-direct glucose metabolites out of the glycolysis pathway and therapeutic uses thereof |
| WO2023091909A1 (en) | 2021-11-16 | 2023-05-25 | Sotio Biotech Inc. | Treatment of myxoid/round cell liposarcoma patients |
| CN120005024A (zh) * | 2022-03-30 | 2025-05-16 | 河北森朗生物科技有限公司 | 抗cd7的纳米抗体及其相关产品和应用 |
| EP4572787A1 (en) | 2022-08-19 | 2025-06-25 | SOTIO Biotech Inc. | Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof |
| WO2024040207A1 (en) | 2022-08-19 | 2024-02-22 | Sotio Biotech Inc. | Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof |
| WO2024102954A1 (en) * | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2024215989A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | ENGINEERED IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-2/IL-15 RECEPTOR βγ AGONISTS |
| WO2024215987A1 (en) | 2023-04-14 | 2024-10-17 | Sotio Biotech Inc. | IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES |
| AU2024269870A1 (en) * | 2023-05-05 | 2025-11-20 | Board Of Regents, The University Of Texas System | Multi-receptor natural killer cells |
| WO2025103439A1 (zh) * | 2023-11-16 | 2025-05-22 | 广州瑞风生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| KR102764613B1 (ko) * | 2024-03-28 | 2025-02-12 | 한양대학교 에리카산학협력단 | NaPi2b 특이적 CAR-T를 포함하는 난소암 치료용 약학 조성물 |
| WO2025235862A1 (en) * | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
| JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| WO1993003769A1 (en) | 1991-08-20 | 1993-03-04 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| EP0644946A4 (en) | 1992-06-10 | 1997-03-12 | Us Health | VECTOR PARTICLES RESISTANT TO HUMAN SERUM INACTIVATION. |
| GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
| EP1024198A3 (en) | 1992-12-03 | 2002-05-29 | Genzyme Corporation | Pseudo-adenoviral vectors for the gene therapy of haemophiliae |
| ATE304604T1 (de) | 1993-06-24 | 2005-09-15 | Frank L Graham | Adenovirus vektoren für gentherapie |
| JPH09501055A (ja) | 1993-07-30 | 1997-02-04 | ユニバーシティ オブ メディシン アンド デンティストリー オブ ニュージャージー | 初代リンパ球への効率的遺伝子転移 |
| BR9407956A (pt) | 1993-10-25 | 1996-11-26 | Canji Inc | Composiçao farmacêutica vetor de express o de adenovirus recombinante e kit par reduzir a proliferaçao de células tumorais |
| US5756910A (en) | 1996-08-28 | 1998-05-26 | Burgett, Inc. | Method and apparatus for actuating solenoids in a player piano |
| BR9713368A (pt) | 1996-11-20 | 2001-09-18 | Introgen Therapeutics Inc | Processo melhorado para a produção e a purificação de vetores adenovirais |
| AU2474700A (en) | 1998-12-01 | 2000-06-19 | Genentech Inc. | Secreted amd transmembrane polypeptides and nucleic acids encoding the same |
| WO2000063374A1 (en) | 1999-04-16 | 2000-10-26 | Celltech Therapeutics Limited | Synthetic transmembrane components |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| PL3006459T3 (pl) * | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| DE102009013748B4 (de) * | 2009-03-17 | 2012-01-26 | Paul-Ehrlich-Institut | Bestimmung von Interaktionen konstanter Antikörperteile mit Fc-gamma Rezeptoren |
| WO2011041093A1 (en) * | 2009-10-01 | 2011-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN103946952A (zh) | 2011-09-16 | 2014-07-23 | 宾夕法尼亚大学董事会 | 用于治疗癌症的rna改造的t细胞 |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| AU2014337195B2 (en) * | 2013-10-17 | 2018-11-08 | National University Of Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
| US20170151283A1 (en) * | 2014-05-23 | 2017-06-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating antibody resistance |
-
2015
- 2015-09-09 SG SG11201701775VA patent/SG11201701775VA/en unknown
- 2015-09-09 WO PCT/US2015/049126 patent/WO2016040441A1/en not_active Ceased
- 2015-09-09 US US15/509,133 patent/US20180133252A9/en not_active Abandoned
- 2015-09-09 KR KR1020177009209A patent/KR20170073593A/ko not_active Withdrawn
- 2015-09-09 MA MA040595A patent/MA40595A/fr unknown
- 2015-09-09 AU AU2015315199A patent/AU2015315199B2/en not_active Ceased
- 2015-09-09 BR BR112017004675A patent/BR112017004675A2/pt not_active IP Right Cessation
- 2015-09-09 EP EP15767396.3A patent/EP3191507A1/en not_active Withdrawn
- 2015-09-09 CN CN201580048652.5A patent/CN107074969A/zh active Pending
- 2015-09-09 SG SG10201902168PA patent/SG10201902168PA/en unknown
- 2015-09-09 JP JP2017533170A patent/JP2017527310A/ja active Pending
- 2015-09-09 MX MX2017003062A patent/MX2017003062A/es unknown
- 2015-09-09 CA CA2972714A patent/CA2972714A1/en not_active Abandoned
-
2017
- 2017-02-27 IL IL250828A patent/IL250828A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017527310A5 (enExample) | ||
| JP7689161B2 (ja) | 多機能性免疫細胞療法 | |
| JP7476298B2 (ja) | Ｍａｇｅ－ａに特異的に結合する抗原結合タンパク質 | |
| CN112074279B (zh) | 人源化bcma抗体和bcma-car-t细胞 | |
| EP3472205B1 (en) | Chimeric antigen receptor | |
| CN109496217B (zh) | 具有cd3结合域的基于多聚体il-15的分子的构造和表征 | |
| CN110300603B (zh) | Cd47-car-t细胞 | |
| JP7749319B2 (ja) | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 | |
| CN108250303B (zh) | 单域抗体融合蛋白及其应用 | |
| RS59373B1 (sr) | Vezujući molekuli za bcma i cd3 | |
| CA2924252A1 (en) | Bi- or multispecific polypeptides binding immune effector cell surface antigens and hbv antigens for treating hbv infections and associated conditions | |
| TW201536805A (zh) | 具有結合ＣＤ３２Ｂ和ＣＤ７９ｂ能力的雙特異性單價Ｆｃ雙抗體及其用途 | |
| CA2975660A1 (en) | Trispecific binding molecules for treating hbv infection and associated conditions | |
| US11332513B2 (en) | Chimeric antigen receptors having GITR intracellular domain as co-stimulatory domain | |
| KR20220025698A (ko) | 다기능 융합 단백질 및 이의 용도 | |
| JP2020536552A5 (enExample) | ||
| CN117425484A (zh) | 多功能免疫细胞疗法 | |
| WO2022148410A1 (zh) | 抗pd-l1/抗4-1bb天然抗体结构样异源二聚体形式双特异抗体及其制备 | |
| CN113474012B (zh) | Epcam抗体和epcam-car-t细胞 | |
| CN111465618A (zh) | 双特异性cd16-结合分子及其在疾病治疗中的用途 | |
| WO2020112529A1 (en) | Car-t cells having humanized cd19 scfv with mutation in cdr 1 region | |
| JP2024517773A (ja) | キメラＦｃα受容体及びその使用 | |
| CN113271965B (zh) | Cd37抗体和cd37-car-t细胞 | |
| CN114040978A (zh) | 用于治疗cd33阳性恶性肿瘤的经cd33靶向性嵌合抗原受体修饰的t细胞 | |
| CN120076819A (zh) | 多结构域结合分子 |