JP2019505565A5 - - Google Patents
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- JP2019505565A5 JP2019505565A5 JP2018546726A JP2018546726A JP2019505565A5 JP 2019505565 A5 JP2019505565 A5 JP 2019505565A5 JP 2018546726 A JP2018546726 A JP 2018546726A JP 2018546726 A JP2018546726 A JP 2018546726A JP 2019505565 A5 JP2019505565 A5 JP 2019505565A5
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- JP
- Japan
- Prior art keywords
- tyr
- leu
- lys
- trp
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001184 polypeptide Polymers 0.000 claims description 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 31
- 230000004927 fusion Effects 0.000 claims description 24
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims description 15
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 15
- 239000000427 antigen Substances 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 9
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 238000006467 substitution reaction Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 4
- 102000013382 Gelatinases Human genes 0.000 claims description 2
- 108010026132 Gelatinases Proteins 0.000 claims description 2
- 102000019298 Lipocalin Human genes 0.000 claims description 2
- 108050006654 Lipocalin Proteins 0.000 claims description 2
- 229960000397 bevacizumab Drugs 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims 26
- 108020001507 fusion proteins Proteins 0.000 claims 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000009075 Angiopoietin-2 Human genes 0.000 claims 1
- 108010048036 Angiopoietin-2 Proteins 0.000 claims 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 14
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15197019 | 2015-11-30 | ||
| EP15197019.1 | 2015-11-30 | ||
| PCT/AU2016/051168 WO2017091850A1 (en) | 2015-11-30 | 2016-11-30 | Novel anti-angiogenic fusion polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019505565A JP2019505565A (ja) | 2019-02-28 |
| JP2019505565A5 true JP2019505565A5 (enExample) | 2020-01-16 |
Family
ID=54754521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546726A Pending JP2019505565A (ja) | 2015-11-30 | 2016-11-30 | 新規の抗血管新生融合ポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10703810B2 (enExample) |
| EP (1) | EP3383921A4 (enExample) |
| JP (1) | JP2019505565A (enExample) |
| KR (1) | KR20180083943A (enExample) |
| CN (1) | CN108699162A (enExample) |
| AU (1) | AU2016363668A1 (enExample) |
| BR (1) | BR112018010887A2 (enExample) |
| CA (1) | CA3004918A1 (enExample) |
| EA (1) | EA035586B1 (enExample) |
| MX (1) | MX2018006559A (enExample) |
| SG (2) | SG11201803732PA (enExample) |
| WO (1) | WO2017091850A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015205530B8 (en) * | 2014-01-13 | 2019-09-19 | Pieris Pharmaceuticals Gmbh | Multi-specific polypeptide useful for localized tumor immunomodulation |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| CN109829882B (zh) * | 2018-12-18 | 2020-10-27 | 广州比格威医疗科技有限公司 | 一种糖尿病视网膜病变分期预测方法 |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20240182553A1 (en) * | 2021-03-25 | 2024-06-06 | Nanjing GenScript Biotech Co., Ltd. | Antibody fusion proteins and uses thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3779221D1 (de) | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| WO1995031479A1 (en) | 1994-05-18 | 1995-11-23 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| WO1996023879A1 (en) | 1995-01-30 | 1996-08-08 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998016873A1 (en) | 1996-10-14 | 1998-04-23 | Firm Forsat Ltd. | Method for preparing dispersions of chromogenic components |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| PL192364B1 (pl) | 1998-06-08 | 2006-10-31 | Hoffmann La Roche | Zastosowanie koniugatu PEG-IFN-α 2A w połączeniu z rybawiryną |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| WO2003029462A1 (en) * | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| EP1430136A1 (en) | 2001-09-27 | 2004-06-23 | Pieris ProteoLab AG | Muteins of apolipoprotein d |
| US7691970B2 (en) | 2003-08-25 | 2010-04-06 | Pieris Ag | Muteins of a bilin-binding protein with affinity for a given target |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| JP2007284351A (ja) | 2004-07-27 | 2007-11-01 | Osaka Bioscience Institute | アミロイド蛋白質の凝集を抑制する物質とその作用 |
| EP2899277A1 (en) | 2004-11-26 | 2015-07-29 | Pieris AG | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
| US20090305963A1 (en) * | 2005-01-19 | 2009-12-10 | Sukhatme Vikas P | Lipocalin 2 for the Treatment, Prevention, and Management of Cancer Metastasis, Angiogenesis, and Fibrosis |
| US20070212703A1 (en) | 2005-09-27 | 2007-09-13 | Stemmer Willem P | Proteinaceous pharmaceuticals and uses thereof |
| CA2702590A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| KR20110013409A (ko) * | 2008-05-23 | 2011-02-09 | 삼성전자주식회사 | 항체-펩티드 융합 상승체 |
| EP2313430B1 (en) | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| US8268314B2 (en) * | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| US8133979B2 (en) | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| MX2011009810A (es) * | 2009-03-27 | 2011-09-30 | Zymogenetics Inc | Composiciones y metodos para usar proteinas de union multiespecificas que comprenden una combinacion anticuerporeceptor. |
| US9549968B2 (en) * | 2009-12-07 | 2017-01-24 | Pieris Pharmaceuticals Gmbh | Muteins of human lipocalin 2 (LcnC,hNGAL) with affinity for a given target |
| TWI426920B (zh) * | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
| CA2808392C (en) * | 2010-08-16 | 2020-03-10 | Pieris Ag | Binding proteins for hepcidin |
| DK2640740T3 (en) | 2010-11-15 | 2017-06-26 | Pieris Pharmaceuticals Gmbh | MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3) |
| SG11201408538PA (en) * | 2012-07-13 | 2015-02-27 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| CA2891557A1 (en) | 2013-03-26 | 2014-05-22 | Pieris Ag | Novel specific-binding polypeptides and uses thereof |
| JP2016528167A (ja) * | 2013-04-29 | 2016-09-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ヒトFcRn結合改変抗体及び使用方法 |
| AU2015205530B8 (en) * | 2014-01-13 | 2019-09-19 | Pieris Pharmaceuticals Gmbh | Multi-specific polypeptide useful for localized tumor immunomodulation |
| CN113621050A (zh) * | 2014-05-22 | 2021-11-09 | 皮里斯制药有限公司 | 新型特异性结合多肽及其用途 |
| AR103477A1 (es) * | 2015-01-28 | 2017-05-10 | Lilly Co Eli | Compuestos de vegfa / ang2 |
| SG10201906859PA (en) | 2015-01-28 | 2019-08-27 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for angiogenesis |
| AR103714A1 (es) | 2015-02-18 | 2017-05-31 | Sanofi Sa | Proteínas específicas para pioverdina y pioquelina |
| US11261221B2 (en) | 2015-05-04 | 2022-03-01 | Pieris Pharmaceuticals Gmbh | Proteins specific for CD137 |
| CN107787327B (zh) | 2015-05-18 | 2022-02-08 | 皮里斯制药有限公司 | 对磷脂酰肌醇聚糖-3(gpc3)具有亲和力的人脂质运载蛋白2的突变蛋白 |
-
2016
- 2016-11-30 SG SG11201803732PA patent/SG11201803732PA/en unknown
- 2016-11-30 CN CN201680080597.2A patent/CN108699162A/zh active Pending
- 2016-11-30 KR KR1020187018593A patent/KR20180083943A/ko not_active Withdrawn
- 2016-11-30 BR BR112018010887A patent/BR112018010887A2/pt not_active Application Discontinuation
- 2016-11-30 WO PCT/AU2016/051168 patent/WO2017091850A1/en not_active Ceased
- 2016-11-30 EP EP16869402.4A patent/EP3383921A4/en not_active Withdrawn
- 2016-11-30 CA CA3004918A patent/CA3004918A1/en not_active Abandoned
- 2016-11-30 JP JP2018546726A patent/JP2019505565A/ja active Pending
- 2016-11-30 SG SG10201911499TA patent/SG10201911499TA/en unknown
- 2016-11-30 EA EA201891141A patent/EA035586B1/ru not_active IP Right Cessation
- 2016-11-30 US US15/777,340 patent/US10703810B2/en not_active Expired - Fee Related
- 2016-11-30 AU AU2016363668A patent/AU2016363668A1/en not_active Abandoned
- 2016-11-30 MX MX2018006559A patent/MX2018006559A/es unknown
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