SG10201911499TA - Novel anti-angiogenic fusion polypeptides - Google Patents

Novel anti-angiogenic fusion polypeptides

Info

Publication number
SG10201911499TA
SG10201911499TA SG10201911499TA SG10201911499TA SG10201911499TA SG 10201911499T A SG10201911499T A SG 10201911499TA SG 10201911499T A SG10201911499T A SG 10201911499TA SG 10201911499T A SG10201911499T A SG 10201911499TA SG 10201911499T A SG10201911499T A SG 10201911499TA
Authority
SG
Singapore
Prior art keywords
fusion polypeptides
novel anti
angiogenic fusion
angiogenic
novel
Prior art date
Application number
SG10201911499TA
Inventor
Shane Olwill
Aiba Rachida Siham Bel
Alexander Wiedenmann
Original Assignee
Pieris Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pieris Australia Pty Ltd filed Critical Pieris Australia Pty Ltd
Publication of SG10201911499TA publication Critical patent/SG10201911499TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/515Angiogenesic factors; Angiogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
SG10201911499TA 2015-11-30 2016-11-30 Novel anti-angiogenic fusion polypeptides SG10201911499TA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15197019 2015-11-30

Publications (1)

Publication Number Publication Date
SG10201911499TA true SG10201911499TA (en) 2020-01-30

Family

ID=54754521

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201803732PA SG11201803732PA (en) 2015-11-30 2016-11-30 Novel anti-angiogenic fusion polypeptides
SG10201911499TA SG10201911499TA (en) 2015-11-30 2016-11-30 Novel anti-angiogenic fusion polypeptides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201803732PA SG11201803732PA (en) 2015-11-30 2016-11-30 Novel anti-angiogenic fusion polypeptides

Country Status (12)

Country Link
US (1) US10703810B2 (en)
EP (1) EP3383921A4 (en)
JP (1) JP2019505565A (en)
KR (1) KR20180083943A (en)
CN (1) CN108699162A (en)
AU (1) AU2016363668A1 (en)
BR (1) BR112018010887A2 (en)
CA (1) CA3004918A1 (en)
EA (1) EA035586B1 (en)
MX (1) MX2018006559A (en)
SG (2) SG11201803732PA (en)
WO (1) WO2017091850A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3094650A2 (en) * 2014-01-13 2016-11-23 Pieris Pharmaceuticals GmbH Multi-specific polypeptide useful for localized tumor immunomodulation
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
BR112018013407A2 (en) 2015-12-30 2018-12-18 Kodiak Sciences Inc antibodies and conjugates thereof
CN109829882B (en) * 2018-12-18 2020-10-27 广州比格威医疗科技有限公司 Method for predicting diabetic retinopathy stage by stage
EP4041312A4 (en) 2019-10-10 2023-12-20 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2022199603A1 (en) * 2021-03-25 2022-09-29 Nanjing GenScript Biotech Co., Ltd. Antibody fusion proteins and uses thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3779221D1 (en) 1986-08-19 1992-06-25 Genentech Inc DEVICE AND DISPERSION FOR THE INTRAPULMONAL ENTERING OF POLYPEPTIDE GROWTH SUBSTANCES AND CYTOKINS.
JPH01215289A (en) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk Production of normal human serum albumin a through gene recombination
FR2649991B2 (en) 1988-08-05 1994-03-04 Rhone Poulenc Sante USE OF STABLE DERIVATIVES OF PLASMID PKD1 FOR THE EXPRESSION AND SECRETION OF HETEROLOGOUS PROTEINS IN YEASTS OF THE GENUS KLUYVEROMYCES
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CN1073119C (en) 1994-05-18 2001-10-17 吸入治疗系统公司 Method and compositions for the dry powder formulation of interferons
DE4417598A1 (en) 1994-05-19 1995-12-14 Max Planck Gesellschaft Use of the tetracycline promoter for the stringently regulated production of recombinant proteins in prokaryotic cells
AU5132096A (en) 1995-01-30 1996-08-21 Terrapin Technologies, Inc. Glubodies - multiplicities of proteins capable of binding a variety of small molecules
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US6620413B1 (en) 1995-12-27 2003-09-16 Genentech, Inc. OB protein-polymer chimeras
DE19641876B4 (en) 1996-10-10 2011-09-29 Iba Gmbh streptavidin muteins
WO1998016873A1 (en) 1996-10-14 1998-04-23 Firm Forsat Ltd. Method for preparing dispersions of chromogenic components
DE19742706B4 (en) 1997-09-26 2013-07-25 Pieris Proteolab Ag lipocalin muteins
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
CA2233725A1 (en) 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
EP1087778B1 (en) 1998-06-08 2005-10-26 F. Hoffmann-La Roche Ag Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
DE19926068C1 (en) 1999-06-08 2001-01-11 Arne Skerra Muteins of the bilin binding protein
JP4336771B2 (en) 2001-03-09 2009-09-30 モルフォシス アーゲー Serum albumin binding moiety
US7118915B2 (en) 2001-09-27 2006-10-10 Pieris Proteolab Ag Muteins of apolipoprotein D
WO2003029462A1 (en) * 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
WO2005019255A1 (en) 2003-08-25 2005-03-03 Pieris Proteolab Ag Muteins of tear lipocalin
EP1658308A1 (en) 2003-08-25 2006-05-24 Pieris ProteoLab AG Muteins of a bilin-binding protein with affinity for a given target
JP2007284351A (en) 2004-07-27 2007-11-01 Osaka Bioscience Institute Substance inhibiting aggregation of amyloid protein and action thereof
WO2006056464A2 (en) 2004-11-26 2006-06-01 Pieris Ag Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4)
US20090305963A1 (en) * 2005-01-19 2009-12-10 Sukhatme Vikas P Lipocalin 2 for the Treatment, Prevention, and Management of Cancer Metastasis, Angiogenesis, and Fibrosis
AU2006294644A1 (en) 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
CA2702612C (en) 2007-10-19 2016-05-03 Abbott Laboratories Antibodies that bind to mammalian ngal and uses thereof
WO2009142460A2 (en) * 2008-05-23 2009-11-26 Samsung Electronics Co., Ltd. Antibody-peptide fused synergibody
EP3381933B1 (en) 2008-06-24 2020-06-03 Technische Universität München Muteins of hngal and related proteins with affinity for a given target
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
US8133979B2 (en) 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
WO2010111625A1 (en) * 2009-03-27 2010-09-30 Zymogenetics, Inc. Compositions and methods for using multispecific-binding proteins comprising an antibody-receptor combination
RU2707126C2 (en) * 2009-12-07 2019-11-22 Пирис Аг Human lipolocal 2 malletes (lcn2, hngal) with affinity for specific target
AR080794A1 (en) * 2010-03-26 2012-05-09 Hoffmann La Roche BIVING SPECIFIC ANTIBODIES ANTI-VEGF / ANTI-ANG-2
CN103154023B (en) 2010-08-16 2017-04-05 皮里斯制药有限公司 The associated proteins of hepcidin
US9260492B2 (en) 2010-11-15 2016-02-16 Pieris Ag Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3)
HRP20211641T1 (en) * 2012-07-13 2022-02-04 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
CA2891557A1 (en) 2013-03-26 2014-05-22 Pieris Ag Novel specific-binding polypeptides and uses thereof
ES2746136T3 (en) * 2013-04-29 2020-03-04 Hoffmann La Roche Modified Human FcRn Binding Antibodies and Methods of Use
EP3094650A2 (en) * 2014-01-13 2016-11-23 Pieris Pharmaceuticals GmbH Multi-specific polypeptide useful for localized tumor immunomodulation
US10774119B2 (en) * 2014-05-22 2020-09-15 Pieris Pharmaceuticals Gmbh Specific-binding polypeptides and uses thereof
AR103477A1 (en) * 2015-01-28 2017-05-10 Lilly Co Eli VEGFA / ANG2 COMPOUNDS
BR112017015773A2 (en) 2015-01-28 2018-03-27 Pieris Pharmaceuticals Gmbh lipocalin mutein, hngal mutein, nucleic acid molecule, host cell, method for producing hngal mutein, pharmaceutical composition, kit, use of hngal mutein, use of hngal mutein, method for binding ang-2 in an individual , method for inhibiting angiogenesis in an individual, method for treating, preventing or ameliorating a disease, and method for inhibiting or reducing angiogenesis in an individual
TN2017000348A1 (en) 2015-02-18 2019-01-16 Sanofi Sa Novel proteins specific for pyoverdine and pyochelin
RU2736312C2 (en) 2015-05-04 2020-11-13 ПИЕРИС ФАРМАСЬЮТИКАЛС ГмбХ Proteins specific for cd137
US10273275B2 (en) 2015-05-18 2019-04-30 Pieris Pharmaceuticals Gmbh Muteins of human lipocalin 2 with affinity for glypican-3 (GPC3) and methods of use thereof

Also Published As

Publication number Publication date
WO2017091850A1 (en) 2017-06-08
JP2019505565A (en) 2019-02-28
EP3383921A4 (en) 2019-04-17
CN108699162A (en) 2018-10-23
CA3004918A1 (en) 2017-06-08
SG11201803732PA (en) 2018-06-28
MX2018006559A (en) 2019-06-12
KR20180083943A (en) 2018-07-23
EP3383921A1 (en) 2018-10-10
US10703810B2 (en) 2020-07-07
BR112018010887A2 (en) 2018-11-21
AU2016363668A1 (en) 2018-05-24
EA201891141A1 (en) 2018-10-31
US20180334499A1 (en) 2018-11-22
EA035586B1 (en) 2020-07-10

Similar Documents

Publication Publication Date Title
ZA201802261B (en) Polypeptides
HK1249526A1 (en) Anti-cancer fusion polypeptide
HK1244019A1 (en) Fusion proteins
IL255767A (en) Novel polypeptides
HK1250041A1 (en) Polypeptides
GB201509413D0 (en) Fusion protein
HK1232136A1 (en) P97-ids fusion proteins p97-ids
SG11201707426SA (en) Anti-cancer fusion polypeptide
SG10201911499TA (en) Novel anti-angiogenic fusion polypeptides
ZA201704366B (en) Il-17a-binding polypeptides
HK1250040A1 (en) Polypeptides
GB201504691D0 (en) Fusion protein
HK1257937A1 (en) Fusion protein
GB201602850D0 (en) Fusion proteins
GB201617799D0 (en) Fusion polypeptide
GB201503789D0 (en) Fusion polypeptide
GB201515245D0 (en) Novel polypeptides
GB201502166D0 (en) Bonding polypeptides