JP2018524326A5 - - Google Patents
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- JP2018524326A5 JP2018524326A5 JP2017566332A JP2017566332A JP2018524326A5 JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5 JP 2017566332 A JP2017566332 A JP 2017566332A JP 2017566332 A JP2017566332 A JP 2017566332A JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5
- Authority
- JP
- Japan
- Prior art keywords
- nkp46
- antigen binding
- binding protein
- polypeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/064063 WO2015197593A1 (en) | 2014-06-27 | 2015-06-23 | MULTISPECIFIC NKp46 BINDING PROTEINS |
| EPPCT/EP2015/064063 | 2015-06-23 | ||
| US201562271459P | 2015-12-28 | 2015-12-28 | |
| US62/271,459 | 2015-12-28 | ||
| PCT/EP2016/064537 WO2016207278A1 (en) | 2015-06-23 | 2016-06-23 | Multispecific nk engager proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524326A JP2018524326A (ja) | 2018-08-30 |
| JP2018524326A5 true JP2018524326A5 (enExample) | 2019-07-04 |
| JP6971153B2 JP6971153B2 (ja) | 2021-11-24 |
Family
ID=57584697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566332A Active JP6971153B2 (ja) | 2015-06-23 | 2016-06-23 | 多重特異的ｎｋエンゲイジャータンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10113003B2 (enExample) |
| EP (1) | EP3313881A1 (enExample) |
| JP (1) | JP6971153B2 (enExample) |
| AU (1) | AU2016284871B2 (enExample) |
| WO (1) | WO2016207278A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| JP6822849B2 (ja) | 2014-06-27 | 2021-01-27 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 多重特異的ＮＫｐ４６結合タンパク質 |
| US9767555B2 (en) * | 2015-01-05 | 2017-09-19 | Case Western Reserve University | Disease characterization from fused pathology and radiology data |
| AU2016284871B2 (en) | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific NK engager proteins |
| DK3313876T3 (da) * | 2015-06-23 | 2025-04-22 | Innate Pharma | Multispecifikke antigenbindende proteiner |
| US10736963B2 (en) | 2015-07-24 | 2020-08-11 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| EP3397645B1 (en) * | 2015-12-28 | 2026-03-25 | Innate Pharma | Variable regions for nkp46 binding proteins |
| US10436795B2 (en) * | 2016-09-16 | 2019-10-08 | Institute For Cancer Research | Carbon-detected NMR for mapping binding sites in intrinsically disordered regions of a protein |
| EP3529277A1 (en) | 2016-10-21 | 2019-08-28 | Innate Pharma | Treatment with anti-kir3dl2 agents |
| US20190322767A1 (en) * | 2016-12-23 | 2019-10-24 | Innate Pharma | Heterodimeric antigen binding proteins |
| AU2018219887B2 (en) | 2017-02-08 | 2024-08-15 | Dragonfly Therapeutics, LLC | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
| MX2019014572A (es) * | 2017-06-05 | 2020-07-29 | Janssen Biotech Inc | Métodos de ingeniería de carga superficial para la producción de anticuerpos biespecíficos. |
| EP3713959A1 (en) * | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| CA3237846A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| WO2019167874A1 (ja) * | 2018-02-27 | 2019-09-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ａｐｏａ４に対するモノクローナル抗体、免疫学的測定方法及び測定用キット |
| KR102578060B1 (ko) * | 2018-03-23 | 2023-09-13 | 한림대학교 산학협력단 | 항균용 항체 및 그 용도 |
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| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| JP2021534096A (ja) * | 2018-08-08 | 2021-12-09 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６および腫瘍関連抗原に結合するタンパク質 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| AU2019412561A1 (en) * | 2018-12-24 | 2021-08-12 | Sanofi | Multispecific binding proteins with mutant Fab domains |
| WO2021113805A1 (en) * | 2019-12-05 | 2021-06-10 | The General Hospital Corporation | Multi-biomarker prediction models for multiple infection episodes following blunt trauma |
| EP4110376A2 (en) * | 2020-02-27 | 2023-01-04 | Novartis AG | Methods of making chimeric antigen receptor-expressing cells |
| US20230183342A1 (en) * | 2020-04-06 | 2023-06-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies to nkp46 and constructs thereof for treatment of cancers and infections |
| JP7512394B2 (ja) | 2020-05-06 | 2024-07-08 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質 |
| US20230348854A1 (en) * | 2020-05-08 | 2023-11-02 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Chimeric antigen receptors (cars) targeting natural killer cells |
| JP2023553313A (ja) | 2020-11-30 | 2023-12-21 | チョ ファーマ インコーポレイテッド | 細胞を富化するための抗体 |
| TWI905354B (zh) * | 2020-12-31 | 2025-11-21 | 法商英耐特醫藥公司 | 結合至NKp46及CD123之多功能自然殺手 (NK) 細胞接合體 |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| WO2022200525A1 (en) | 2021-03-26 | 2022-09-29 | Innate Pharma | Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging |
| EP4320164A4 (en) * | 2021-04-05 | 2025-07-16 | Naya Biosciences Inc | BISPECIFIC ANTIBODIES TARGETING NKP46 AND CD38 AND METHODS OF USE THEREOF |
| JP2024513264A (ja) * | 2021-04-05 | 2024-03-22 | サイトヴィア セラピューティクス， エルエルシー | Ｎｋｐ４６及びｇｐｃ３を標的とする二重特異性抗体、並びにその使用方法 |
| KR20240019786A (ko) * | 2021-06-09 | 2024-02-14 | 이나뜨 파르마 에스.에이. | Cd20, nkp46, cd16에 결합하고 il-2에 접합된 다중특이적 항체 |
| BR112023025331A2 (pt) | 2021-06-09 | 2024-02-27 | Innate Pharma | Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso |
| US20240279331A1 (en) * | 2021-06-11 | 2024-08-22 | The Regents Of The University Of California | Antibodies that stimulate nk cell-mediated cytotoxicity |
| EP4363450A1 (en) | 2021-07-01 | 2024-05-08 | Compugen Ltd. | Anti-tigit and anti-pvrig in monotherapy and combination treatments |
| US20240376198A1 (en) * | 2021-08-30 | 2024-11-14 | Inhibrx, Inc. | NKp46-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| JP2024534838A (ja) * | 2021-08-30 | 2024-09-26 | インヒブルクス インコーポレイテッド | ＮＫｐ４６結合ポリペプチド及びその使用 |
| KR20250017240A (ko) | 2022-05-27 | 2025-02-04 | 사노피 | FC-조작을 갖는 NKp46 및 BCMA 변이체에 결합하는 자연 살해(NK) 세포 관여자 |
| IL319568A (en) | 2022-09-15 | 2025-05-01 | Avidicure Ip B V | Multispecific antigen-binding proteins for NK cell stimulation and their uses |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
| WO2025193146A1 (en) | 2024-03-13 | 2025-09-18 | Berg Thoren Fredrik | Trail receptor binding molecules |
| WO2025191139A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Conjugates of her2-specific antigen binding proteins and cytokines |
| WO2025191133A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Il-21 muteins, fusion proteins comprising the same and uses thereof |
| WO2025191136A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof |
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| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| JP6822849B2 (ja) | 2014-06-27 | 2021-01-27 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 多重特異的ＮＫｐ４６結合タンパク質 |
| DK3313876T3 (da) | 2015-06-23 | 2025-04-22 | Innate Pharma | Multispecifikke antigenbindende proteiner |
| AU2016284871B2 (en) | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific NK engager proteins |
| EP3397645B1 (en) * | 2015-12-28 | 2026-03-25 | Innate Pharma | Variable regions for nkp46 binding proteins |
-
2016
- 2016-06-23 AU AU2016284871A patent/AU2016284871B2/en active Active
- 2016-06-23 WO PCT/EP2016/064537 patent/WO2016207278A1/en not_active Ceased
- 2016-06-23 JP JP2017566332A patent/JP6971153B2/ja active Active
- 2016-06-23 US US15/190,337 patent/US10113003B2/en active Active
- 2016-06-23 EP EP16734592.5A patent/EP3313881A1/en active Pending
-
2018
- 2018-10-29 US US16/173,114 patent/US11267897B2/en active Active
- 2018-10-29 US US16/173,150 patent/US12252543B2/en active Active
-
2025
- 2025-01-06 US US19/010,723 patent/US20250215107A1/en active Pending
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