JP2018524326A5 - - Google Patents
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- Publication number
- JP2018524326A5 JP2018524326A5 JP2017566332A JP2017566332A JP2018524326A5 JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5 JP 2017566332 A JP2017566332 A JP 2017566332A JP 2017566332 A JP2017566332 A JP 2017566332A JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5
- Authority
- JP
- Japan
- Prior art keywords
- nkp46
- antigen binding
- binding protein
- polypeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000025171 antigen binding proteins Human genes 0.000 claims 16
- 108091000831 antigen binding proteins Proteins 0.000 claims 16
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 14
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000009089 cytolysis Effects 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000589301 Homo sapiens Natural cytotoxicity triggering receptor 1 Proteins 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 102100024184 Polymerase delta-interacting protein 3 Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 239000004161 brilliant blue FCF Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 102000053350 human FCGR3B Human genes 0.000 claims 1
- 102000050738 human NCR1 Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/064063 WO2015197593A1 (en) | 2014-06-27 | 2015-06-23 | MULTISPECIFIC NKp46 BINDING PROTEINS |
| EPPCT/EP2015/064063 | 2015-06-23 | ||
| US201562271459P | 2015-12-28 | 2015-12-28 | |
| US62/271,459 | 2015-12-28 | ||
| PCT/EP2016/064537 WO2016207278A1 (en) | 2015-06-23 | 2016-06-23 | Multispecific nk engager proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524326A JP2018524326A (ja) | 2018-08-30 |
| JP2018524326A5 true JP2018524326A5 (enExample) | 2019-07-04 |
| JP6971153B2 JP6971153B2 (ja) | 2021-11-24 |
Family
ID=57584697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566332A Active JP6971153B2 (ja) | 2015-06-23 | 2016-06-23 | 多重特異的ｎｋエンゲイジャータンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US10113003B2 (enExample) |
| EP (1) | EP3313881A1 (enExample) |
| JP (1) | JP6971153B2 (enExample) |
| AU (1) | AU2016284871B2 (enExample) |
| CA (1) | CA2990518A1 (enExample) |
| WO (1) | WO2016207278A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10519234B2 (en) | 2014-06-27 | 2019-12-31 | Innate Pharma | NKp46 binding proteins |
| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| US9767555B2 (en) * | 2015-01-05 | 2017-09-19 | Case Western Reserve University | Disease characterization from fused pathology and radiology data |
| AU2016284866B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| AU2016284871B2 (en) | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific NK engager proteins |
| CA2990520C (en) | 2015-07-24 | 2023-06-27 | Innate Pharma | Methods for detecting tissue infiltrating nk cells |
| AU2016383475B2 (en) | 2015-12-28 | 2024-02-22 | Innate Pharma | Variable regions for NKp46 binding proteins |
| US10436795B2 (en) * | 2016-09-16 | 2019-10-08 | Institute For Cancer Research | Carbon-detected NMR for mapping binding sites in intrinsically disordered regions of a protein |
| AU2017345203B2 (en) | 2016-10-21 | 2024-08-01 | Innate Pharma | Treatment with anti-KIR3DL2 agents |
| EP3559032A1 (en) * | 2016-12-23 | 2019-10-30 | Innate Pharma | Heterodimeric antigen binding proteins |
| KR20240023449A (ko) | 2017-02-08 | 2024-02-21 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| JP7685821B2 (ja) | 2017-02-20 | 2025-05-30 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｈｅｒ２、ＮＫＧ２ＤおよびＣＤ１６に結合するタンパク質 |
| JP7268011B2 (ja) | 2017-06-05 | 2023-05-02 | ヤンセン バイオテツク，インコーポレーテツド | 二重特異性抗体製造のための表面電荷を工学的に操作する方法 |
| EP3713959A1 (en) | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| PT3749346T (pt) | 2018-02-08 | 2024-09-05 | Dragonfly Therapeutics Inc | Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| CA3091424A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| JPWO2019167874A1 (ja) * | 2018-02-27 | 2021-03-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ａｐｏａ４に対するモノクローナル抗体、免疫学的測定方法及び測定用キット |
| KR102578060B1 (ko) * | 2018-03-23 | 2023-09-13 | 한림대학교 산학협력단 | 항균용 항체 및 그 용도 |
| KR20200143436A (ko) * | 2018-04-13 | 2020-12-23 | 아피메트 게엠베하 | Nk 세포 결합 항체 융합 구조체 |
| EP3797120A1 (en) | 2018-05-21 | 2021-03-31 | Compass Therapeutics LLC | Compositions and methods for enhancing the killing of target cells by nk cells |
| WO2020033702A1 (en) * | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| SG11202101298XA (en) | 2018-08-08 | 2021-03-30 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
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| WO2021205438A1 (en) * | 2020-04-06 | 2021-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies to nkp46 and constructs thereof for treatment of cancers and infections |
| CA3177024A1 (en) | 2020-05-06 | 2021-11-11 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and clec12a |
| CN115551893A (zh) * | 2020-05-08 | 2022-12-30 | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 靶向自然杀伤细胞的嵌合抗原受体(car) |
| US12421305B2 (en) | 2020-11-30 | 2025-09-23 | Cho Pharma, Inc. | Antibody for enrichment of cells |
| JP7623497B2 (ja) | 2020-12-31 | 2025-01-28 | サノフイ | ＮＫｐ４６およびＣＤ１２３に結合する多機能性ナチュラルキラー（ＮＫ）細胞エンゲージャ |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| AU2022246048A1 (en) | 2021-03-26 | 2023-08-31 | Innate Pharma | Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging |
| EP4319810A4 (en) * | 2021-04-05 | 2025-06-18 | Naya Biosciences Inc. | Bispecific antibodies targeting nkp46 and gpc3 and methods of use thereof |
| KR20240021153A (ko) * | 2021-04-05 | 2024-02-16 | 사이토비아 테라퓨틱스, 엘엘씨. | Nkp46 및 cd38를 표적으로 하는 이중 특이적 항체 및 이의 사용 방법 |
| IL308531A (en) * | 2021-06-09 | 2024-01-01 | Innate Pharma | Multispecific antibodies binding to cd20, nkp46, cd16 and conjugated to il-2 |
| KR20240019297A (ko) | 2021-06-09 | 2024-02-14 | 이나뜨 파르마 에스.에이. | Nkp46, 사이토카인 수용체, 종양 항원 및 cd16a 에 결합하는 다중특이적 단백질 |
| US20240279331A1 (en) * | 2021-06-11 | 2024-08-22 | The Regents Of The University Of California | Antibodies that stimulate nk cell-mediated cytotoxicity |
| EP4363450A1 (en) | 2021-07-01 | 2024-05-08 | Compugen Ltd. | Anti-tigit and anti-pvrig in monotherapy and combination treatments |
| US20240376198A1 (en) * | 2021-08-30 | 2024-11-14 | Inhibrx, Inc. | NKp46-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| CN117940454A (zh) * | 2021-08-30 | 2024-04-26 | 印希比股份有限公司 | NKp46结合多肽及其用途 |
| TW202413419A (zh) | 2022-05-27 | 2024-04-01 | 法商賽諾菲公司 | 與ｎｋｐ４６和ｂｃｍａ變體結合之具有ｆｃ工程化的自然殺手（ｎｋ）細胞接合物 |
| AU2023342646A1 (en) | 2022-09-15 | 2025-02-20 | Avidicure Ip B.V. | Multispecific antigen binding proteins for stimulating nk cells and use thereof |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
| WO2025193146A1 (en) | 2024-03-13 | 2025-09-18 | Berg Thoren Fredrik | Trail receptor binding molecules |
| WO2025191144A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Conjugates of egfr-specific antigen binding proteins and cytokines |
| WO2025191133A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Il-21 muteins, fusion proteins comprising the same and uses thereof |
| WO2025191136A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof |
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| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| US10519234B2 (en) * | 2014-06-27 | 2019-12-31 | Innate Pharma | NKp46 binding proteins |
| AU2016284871B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific NK engager proteins |
| AU2016284866B2 (en) | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| AU2016383475B2 (en) * | 2015-12-28 | 2024-02-22 | Innate Pharma | Variable regions for NKp46 binding proteins |
-
2016
- 2016-06-23 AU AU2016284871A patent/AU2016284871B2/en active Active
- 2016-06-23 US US15/190,337 patent/US10113003B2/en active Active
- 2016-06-23 WO PCT/EP2016/064537 patent/WO2016207278A1/en not_active Ceased
- 2016-06-23 JP JP2017566332A patent/JP6971153B2/ja active Active
- 2016-06-23 EP EP16734592.5A patent/EP3313881A1/en active Pending
- 2016-06-23 CA CA2990518A patent/CA2990518A1/en active Pending
-
2018
- 2018-10-29 US US16/173,150 patent/US12252543B2/en active Active
- 2018-10-29 US US16/173,114 patent/US11267897B2/en active Active
-
2025
- 2025-01-06 US US19/010,723 patent/US20250215107A1/en active Pending
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