JP2018524326A5 - - Google Patents
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- JP2018524326A5 JP2018524326A5 JP2017566332A JP2017566332A JP2018524326A5 JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5 JP 2017566332 A JP2017566332 A JP 2017566332A JP 2017566332 A JP2017566332 A JP 2017566332A JP 2018524326 A5 JP2018524326 A5 JP 2018524326A5
- Authority
- JP
- Japan
- Prior art keywords
- nkp46
- antigen binding
- binding protein
- polypeptide
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/064063 | 2015-06-23 | ||
| PCT/EP2015/064063 WO2015197593A1 (en) | 2014-06-27 | 2015-06-23 | MULTISPECIFIC NKp46 BINDING PROTEINS |
| US201562271459P | 2015-12-28 | 2015-12-28 | |
| US62/271,459 | 2015-12-28 | ||
| PCT/EP2016/064537 WO2016207278A1 (en) | 2015-06-23 | 2016-06-23 | Multispecific nk engager proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524326A JP2018524326A (ja) | 2018-08-30 |
| JP2018524326A5 true JP2018524326A5 (enExample) | 2019-07-04 |
| JP6971153B2 JP6971153B2 (ja) | 2021-11-24 |
Family
ID=57584697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566332A Active JP6971153B2 (ja) | 2015-06-23 | 2016-06-23 | 多重特異的ｎｋエンゲイジャータンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10113003B2 (enExample) |
| EP (1) | EP3313881A1 (enExample) |
| JP (1) | JP6971153B2 (enExample) |
| AU (1) | AU2016284871B2 (enExample) |
| WO (1) | WO2016207278A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| US10519234B2 (en) | 2014-06-27 | 2019-12-31 | Innate Pharma | NKp46 binding proteins |
| US9767555B2 (en) * | 2015-01-05 | 2017-09-19 | Case Western Reserve University | Disease characterization from fused pathology and radiology data |
| WO2016207278A1 (en) * | 2015-06-23 | 2016-12-29 | Innate Pharma | Multispecific nk engager proteins |
| AU2016284866B2 (en) * | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| EP3325967B1 (en) | 2015-07-24 | 2019-12-04 | Innate Pharma | Methods for detecting tissue infiltrating nk cells |
| CN115925933A (zh) | 2015-12-28 | 2023-04-07 | 依奈特制药公司 | NKp46结合蛋白的可变区 |
| US10436795B2 (en) * | 2016-09-16 | 2019-10-08 | Institute For Cancer Research | Carbon-detected NMR for mapping binding sites in intrinsically disordered regions of a protein |
| WO2018073363A1 (en) | 2016-10-21 | 2018-04-26 | Innate Pharma | Treatment with anti-kir3dl2 agents |
| WO2018115262A1 (en) * | 2016-12-23 | 2018-06-28 | Innate Pharma | Heterodimeric antigen binding proteins |
| EP4491234A3 (en) | 2017-02-08 | 2025-04-09 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| BR112019017197A2 (pt) | 2017-02-20 | 2020-04-14 | Dragonfly Therapeutics, Inc. | proteínas que se ligam a her2, nkg2d e cd16 |
| AU2018279278A1 (en) | 2017-06-05 | 2019-12-19 | Janssen Biotech, Inc. | Methods of engineering surface charge for bispecific antibody production |
| EP3713959A1 (en) * | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| AU2019218125B2 (en) | 2018-02-08 | 2025-03-13 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
| TW201942134A (zh) | 2018-02-20 | 2019-11-01 | 美商蜻蜓醫療公司 | 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法 |
| WO2019167874A1 (ja) * | 2018-02-27 | 2019-09-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ａｐｏａ４に対するモノクローナル抗体、免疫学的測定方法及び測定用キット |
| KR102578060B1 (ko) * | 2018-03-23 | 2023-09-13 | 한림대학교 산학협력단 | 항균용 항체 및 그 용도 |
| PE20201346A1 (es) * | 2018-04-13 | 2020-11-25 | Affimed Gmbh | Constructos de fusion de anticuerpos que se acoplan a celulas nk |
| EP3797120A1 (en) | 2018-05-21 | 2021-03-31 | Compass Therapeutics LLC | Compositions and methods for enhancing the killing of target cells by nk cells |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| CN112789291A (zh) * | 2018-08-08 | 2021-05-11 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN113795508A (zh) * | 2018-12-24 | 2021-12-14 | 赛诺菲 | 具有突变型Fab结构域的多特异性结合蛋白 |
| WO2021113805A1 (en) * | 2019-12-05 | 2021-06-10 | The General Hospital Corporation | Multi-biomarker prediction models for multiple infection episodes following blunt trauma |
| KR20220146530A (ko) * | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
| CA3179348A1 (en) * | 2020-04-06 | 2021-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies to nkp46 and constructs thereof for treatment of cancers and infections |
| EP4146271A4 (en) | 2020-05-06 | 2024-09-04 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A |
| JP2023525049A (ja) * | 2020-05-08 | 2023-06-14 | シアトル・チルドレンズ・ホスピタル・ドゥーイング／ビジネス／アズ・シアトル・チルドレンズ・リサーチ・インスティテュート | ナチュラルキラー細胞を標的とするキメラ抗原受容体（ｃａｒ） |
| AU2021385606B2 (en) | 2020-11-30 | 2026-02-05 | Cho Pharma, Inc. | Antibody for enrichment of cells |
| JP7623497B2 (ja) | 2020-12-31 | 2025-01-28 | サノフイ | ＮＫｐ４６およびＣＤ１２３に結合する多機能性ナチュラルキラー（ＮＫ）細胞エンゲージャ |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| KR20230162013A (ko) | 2021-03-26 | 2023-11-28 | 이나뜨 파르마 에스.에이. | Nk 세포 관여를 위해 사이토카인에 융합된 nkp46-결합 부위, 암 항원 결합 부위를 포함하는 다중특이적 단백질 |
| US20240199759A1 (en) * | 2021-04-05 | 2024-06-20 | Cytovia Therapeutics, Llc. | Bispecific antibodies targeting nkp46 and gpc3 and methods of use thereof |
| BR112023020574A2 (pt) * | 2021-04-05 | 2023-12-12 | Cytovia Therapeutics Llc | Anticorpos biespecíficos alvejados a nkp46 e cd38 e métodos de uso dos mesmos |
| MX2023014645A (es) * | 2021-06-09 | 2024-01-31 | Innate Pharma | Proteinas acopladoras de celulas nk de union a nkp46 especificas de cd20. |
| CN117616050A (zh) | 2021-06-09 | 2024-02-27 | 先天制药公司 | 与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质 |
| CN117858900A (zh) * | 2021-06-11 | 2024-04-09 | 加利福尼亚大学董事会 | 刺激nk细胞介导的细胞毒性的抗体 |
| EP4588524A3 (en) | 2021-07-01 | 2025-09-03 | Compugen Ltd. | Anti-tigit and anti-pvrig in monotherapy and combination treatments |
| US20240376198A1 (en) * | 2021-08-30 | 2024-11-14 | Inhibrx, Inc. | NKp46-Targeted Modified IL-2 Polypeptides and Uses Thereof |
| CN117940454A (zh) * | 2021-08-30 | 2024-04-26 | 印希比股份有限公司 | NKp46结合多肽及其用途 |
| TW202413419A (zh) * | 2022-05-27 | 2024-04-01 | 法商賽諾菲公司 | 與ｎｋｐ４６和ｂｃｍａ變體結合之具有ｆｃ工程化的自然殺手（ｎｋ）細胞接合物 |
| CN119998330A (zh) | 2022-09-15 | 2025-05-13 | 艾维迪治疗知识产权有限公司 | 用于刺激nk细胞的多特异性抗原结合蛋白及其用途 |
| WO2024208818A1 (en) | 2023-04-04 | 2024-10-10 | Innate Pharma | Modular chimeric antigen receptor |
| WO2025193146A1 (en) | 2024-03-13 | 2025-09-18 | Berg Thoren Fredrik | Trail receptor binding molecules |
| WO2025191137A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Conjugates of trop2-specific antigen binding proteins and cytokines |
| WO2025191136A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof |
| WO2025191133A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Il-21 muteins, fusion proteins comprising the same and uses thereof |
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| CN104768581A (zh) * | 2012-09-07 | 2015-07-08 | 吉宁特有限公司 | II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗 |
| CN104640880B (zh) | 2012-09-19 | 2020-06-09 | 先天制药公司 | Kir3dl2结合剂 |
| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| US10519234B2 (en) * | 2014-06-27 | 2019-12-31 | Innate Pharma | NKp46 binding proteins |
| AU2016284866B2 (en) | 2015-06-23 | 2022-09-29 | Innate Pharma | Multispecific antigen binding proteins |
| WO2016207278A1 (en) * | 2015-06-23 | 2016-12-29 | Innate Pharma | Multispecific nk engager proteins |
| CN115925933A (zh) * | 2015-12-28 | 2023-04-07 | 依奈特制药公司 | NKp46结合蛋白的可变区 |
-
2016
- 2016-06-23 WO PCT/EP2016/064537 patent/WO2016207278A1/en not_active Ceased
- 2016-06-23 JP JP2017566332A patent/JP6971153B2/ja active Active
- 2016-06-23 AU AU2016284871A patent/AU2016284871B2/en active Active
- 2016-06-23 EP EP16734592.5A patent/EP3313881A1/en active Pending
- 2016-06-23 US US15/190,337 patent/US10113003B2/en active Active
-
2018
- 2018-10-29 US US16/173,150 patent/US12252543B2/en active Active
- 2018-10-29 US US16/173,114 patent/US11267897B2/en active Active
-
2025
- 2025-01-06 US US19/010,723 patent/US20250215107A1/en active Pending
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