JP2018529327A5 - - Google Patents

Download PDF

Info

Publication number
JP2018529327A5
JP2018529327A5 JP2018509805A JP2018509805A JP2018529327A5 JP 2018529327 A5 JP2018529327 A5 JP 2018529327A5 JP 2018509805 A JP2018509805 A JP 2018509805A JP 2018509805 A JP2018509805 A JP 2018509805A JP 2018529327 A5 JP2018529327 A5 JP 2018529327A5
Authority
JP
Japan
Prior art keywords
antibody
seq
amino acid
acid sequence
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018509805A
Other languages
English (en)
Japanese (ja)
Other versions
JP6994456B2 (ja
JP2018529327A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2016/096292 external-priority patent/WO2017032293A1/zh
Publication of JP2018529327A publication Critical patent/JP2018529327A/ja
Publication of JP2018529327A5 publication Critical patent/JP2018529327A5/ja
Application granted granted Critical
Publication of JP6994456B2 publication Critical patent/JP6994456B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018509805A 2015-08-21 2016-08-22 抗メソテリン完全ヒト抗体およびメソテリンを標的とする免疫エフェクター細胞 Expired - Fee Related JP6994456B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510519214.4 2015-08-21
CN201510519214 2015-08-21
PCT/CN2016/096292 WO2017032293A1 (zh) 2015-08-21 2016-08-22 抗间皮素全人抗体以及靶向间皮素的免疫效应细胞

Publications (3)

Publication Number Publication Date
JP2018529327A JP2018529327A (ja) 2018-10-11
JP2018529327A5 true JP2018529327A5 (enExample) 2019-10-03
JP6994456B2 JP6994456B2 (ja) 2022-02-04

Family

ID=58099641

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018509805A Expired - Fee Related JP6994456B2 (ja) 2015-08-21 2016-08-22 抗メソテリン完全ヒト抗体およびメソテリンを標的とする免疫エフェクター細胞

Country Status (15)

Country Link
US (1) US10793641B2 (enExample)
EP (1) EP3339326A4 (enExample)
JP (1) JP6994456B2 (enExample)
KR (1) KR20180055824A (enExample)
CN (1) CN106467573B (enExample)
AU (1) AU2016312015A1 (enExample)
BR (1) BR112018003339A8 (enExample)
CA (1) CA2996060A1 (enExample)
CL (1) CL2018000457A1 (enExample)
HK (1) HK1251948A1 (enExample)
IL (1) IL257563A (enExample)
NZ (1) NZ740855A (enExample)
RU (1) RU2748281C2 (enExample)
SG (1) SG11201801351RA (enExample)
WO (1) WO2017032293A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
CA2898100C (en) 2013-01-14 2023-10-10 Xencor, Inc. Novel heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
SG11201704283PA (en) 2014-11-26 2017-06-29 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
JP2017536830A (ja) 2014-11-26 2017-12-14 ゼンコー・インコーポレイテッドXencor、 Inc. Cd3及びcd38に結合するヘテロ二量体抗体
KR20190020341A (ko) 2016-06-28 2019-02-28 젠코어 인코포레이티드 소마토스타틴 수용체 2에 결합하는 이종이량체 항체
CA3074128A1 (en) 2017-08-28 2019-03-07 Shanghai Yile Biotechnology Co., Ltd. Polypeptide and antibody bound to polypeptide
CN107557336B (zh) * 2017-09-15 2020-02-14 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用
CN107488636A (zh) * 2017-09-30 2017-12-19 山东兴瑞生物科技有限公司 一种携带分子开关的抗her2嵌合抗原受体修饰的免疫细胞及其应用
KR101966362B1 (ko) 2017-10-20 2019-04-05 주식회사 녹십자 항-msln 항체 및 이를 포함하는 암 치료용 약학적 조성물
JP6339283B1 (ja) * 2017-10-31 2018-06-06 国立大学法人 岡山大学 Dna、ポリペプチド、抗メソセリン抗体、腫瘍イメージング剤及び複合体
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
CN109971717B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 共表达cd40抗体与间皮素特异性嵌合抗原受体的t细胞及其用途
CN109971714B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 自表达pd-1抗体并靶向间皮素的嵌合抗原受体修饰t细胞及其用途
CN109608549B (zh) * 2017-12-29 2022-02-18 郑州大学第一附属医院 基于人源间皮素抗体的嵌合抗原受体、慢病毒表达载体及其应用
KR20200143672A (ko) 2018-02-02 2020-12-24 카르스젠 테라퓨틱스 컴퍼니, 리미티드 세포 면역 치료의 조합
WO2019173324A1 (en) 2018-03-06 2019-09-12 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
KR20210013013A (ko) 2018-03-09 2021-02-03 카르스젠 테라퓨틱스 리미티드 종양 치료 방법 및 조성물
WO2019191334A1 (en) * 2018-03-28 2019-10-03 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
EP3774865A1 (en) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Cellular immunotherapy compositions and uses thereof
AU2019247415A1 (en) 2018-04-04 2020-10-22 Xencor, Inc. Heterodimeric antibodies that bind fibroblast activation protein
CN112074600A (zh) 2018-05-03 2020-12-11 科济生物医药(上海)有限公司 免疫效应细胞及其应用
JP2021523743A (ja) 2018-05-15 2021-09-09 カースゲン セラピューティクス カンパニー リミテッドCarsgen Therapeutics Co., Ltd. 遺伝子操作された細胞及びその応用
EP3807321A4 (en) * 2018-06-18 2022-03-02 Anwita Biosciences, Inc. ANTI-MESOTHELIN CONSTRUCTS AND USES THEREOF
JP7262568B2 (ja) 2018-07-24 2023-04-21 クレージュ メディカル カンパニー,リミテッド 免疫エフェクター細胞を使用して腫瘍を治療する方法
CN109097396B (zh) * 2018-09-10 2022-10-11 上海细胞治疗集团有限公司 一种制备靶向间皮素的car-t细胞的方法
WO2020114518A1 (zh) 2018-12-07 2020-06-11 科济生物医药(上海)有限公司 肿瘤联合免疫治疗
CN111381020B (zh) * 2018-12-27 2024-06-28 上海细胞治疗集团股份有限公司 一种间皮素car-t细胞免疫组化染色试剂盒及其应用
CN109666074B (zh) * 2018-12-29 2020-04-24 广州百暨基因科技有限公司 一种趋化因子受体cxcr5的用途
KR20210126008A (ko) 2019-01-07 2021-10-19 카르스젠 테라퓨틱스 컴퍼니, 리미티드 세포 면역 치료의 조합
CN109680004B (zh) * 2019-01-09 2025-03-21 上海美丽人生医疗科技有限公司 联合EpCAM和MSLN单链抗体的双靶点CAR载体及其构建方法和在卵巢癌中的应用
KR102070016B1 (ko) * 2019-01-21 2020-01-29 (주)녹십자셀 메소텔린 특이적인 키메라 항원 수용체 및 이를 발현하는 t 세포
CN113490689B (zh) 2019-02-01 2024-06-04 恺兴生命科技(上海)有限公司 Tcr融合蛋白及表达tcr融合蛋白的细胞
CN110055269B (zh) * 2019-03-20 2021-03-16 英威福赛生物技术有限公司 人间皮素嵌合抗原受体、其t细胞及其制备方法和用途
KR20220035908A (ko) * 2019-06-19 2022-03-22 실버백 테라퓨틱스, 인크. 항-메소텔린 항체 및 이의 면역접합체
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
EP4149632A1 (en) * 2020-05-14 2023-03-22 Xencor, Inc. Heterodimeric antibodies that bind msln and cd3
CA3133678C (en) * 2020-08-04 2023-04-11 Cellengene Inc. Anti-mesothelin chimeric antigen receptor specifically binding to mesothelin
WO2022030730A1 (ko) * 2020-08-04 2022-02-10 주식회사 셀렌진 메소텔린에 특이적으로 결합하는 항-메소텔린 키메릭 항원 수용체
WO2022028623A1 (zh) 2020-08-07 2022-02-10 佧珐药业有限公司 工程化改造的细胞以及工程化改造细胞的方法
US20250269026A1 (en) * 2020-10-15 2025-08-28 Chengdu Kelun Precision Biotechnology Co., Ltd. Chimeric antigen receptor which specifically binds to msln, and application thereof
CN116685604A (zh) * 2020-12-09 2023-09-01 南京再明医药有限公司 抗人msln的抗体及其用途
KR20230156079A (ko) 2021-03-09 2023-11-13 젠코어 인코포레이티드 Cd3과 cldn6에 결합하는 이종이량체 항체
US11859012B2 (en) 2021-03-10 2024-01-02 Xencor, Inc. Heterodimeric antibodies that bind CD3 and GPC3
CN117545771A (zh) 2021-04-08 2024-02-09 克莱格医学有限公司 细胞免疫治疗的应用
WO2022250450A1 (ko) * 2021-05-26 2022-12-01 주식회사 셀렌진 항 메소텔린 scFv를 포함하는 키메릭 항원 수용체 및 이의 용도
JP2024523636A (ja) 2021-06-29 2024-06-28 科済生物医薬(上海)有限公司 細胞の生理活性を調節するキメラポリペプチド
KR102860436B1 (ko) * 2021-06-30 2025-09-19 (주)이노베이션바이오 메소텔린 특이적 항체 및 이의 용도
CN115989242A (zh) * 2021-08-16 2023-04-18 上海优替济生生物医药有限公司 间皮素靶向抗体、嵌合抗原受体及其应用
CN113788896A (zh) * 2021-08-25 2021-12-14 南京蓝盾生物科技有限公司 抗msln单克隆内化抗体及其制备方法和应用
CN114015720A (zh) * 2021-09-29 2022-02-08 昆明市延安医院 具有靶向高强度杀瘤活性的Mesothelin嵌合抗原受体修饰的T细胞的制备方法
TW202321296A (zh) 2021-10-06 2023-06-01 美商鏈接免疫療法公司 抗間皮素抗原結合分子及其用途
EP4426747A4 (en) * 2021-11-04 2025-10-15 Massachusetts Gen Hospital ANTI-MESOTHELIN ANTIBODY REAGENTS
WO2023116637A1 (zh) * 2021-12-21 2023-06-29 深圳市菲鹏生物治疗股份有限公司 转基因免疫细胞及其构建方法和应用
CN114276454B (zh) * 2021-12-29 2022-12-20 华道(上海)生物医药有限公司 一种抗间皮素的纳米抗体及其应用
WO2023138666A1 (en) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Circular rna and use thereof
TW202542203A (zh) * 2022-07-11 2025-11-01 中國商諾納生物(蘇州)有限公司 抗間皮素抗體
EP4613771A1 (en) * 2022-11-02 2025-09-10 Cellengene Inc Chimeric antigen receptor with increased affinity for mesothelin and use thereof
KR102938027B1 (ko) * 2022-11-11 2026-03-13 주식회사 유씨아이테라퓨틱스 유전자 조작된 세포 및 이의 용도
CN116003638B (zh) * 2023-01-20 2023-09-05 北京基因启明生物科技有限公司 一种有效杀伤胆管型肝癌的CAR-iNKT细胞技术
WO2025063790A1 (ko) * 2023-09-20 2025-03-27 주식회사 유씨아이테라퓨틱스 항-메소텔린 항체 및 이의 용도
CN117327184B (zh) * 2023-12-01 2024-03-05 赛奥斯博生物科技(北京)有限公司 一种靶向msln的嵌合抗原受体及其应用
CN117843793B (zh) * 2024-03-07 2024-07-09 深圳真实生物医药科技有限公司 抗间皮素抗体、抗原结合片段及其用途
WO2025195483A1 (en) * 2024-03-21 2025-09-25 Utc Therapeutics (Shanghai) Co., Ltd. Mesothelin targetting antibodies, chimeric antigen receptors, and uses thereof
CN119751681A (zh) * 2024-12-30 2025-04-04 北京百替生物技术有限公司 抗间皮素的单链抗体、mRNA及其应用和核酸药物
CN121021700A (zh) * 2025-08-29 2025-11-28 典晶医药(无锡)有限公司 一种抗间皮素抗体及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
EP2322560B1 (en) * 2005-03-10 2013-09-04 Morphotek, Inc. Anti-mesothelin antibodies
SI2195017T1 (sl) * 2007-10-01 2015-01-30 Bristol-Myers Squibb Company Človeška protitelesa, ki vežejo mezotelin in njihova uporaba
HUE027358T2 (en) * 2007-11-26 2016-09-28 Bayer Ip Gmbh Anti-mesothelin antibodies and their applications
AU2009228361A1 (en) * 2008-03-27 2009-10-01 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human anti-mesothelin monoclonal antibodies
AU2010230063B2 (en) * 2009-03-24 2015-06-25 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anti-mesothelin antibodies
UY32560A (es) * 2009-04-29 2010-11-30 Bayer Schering Pharma Ag Inmunoconjugados de antimesotelina y usos de los mismos
PE20170917A1 (es) * 2010-12-20 2017-07-12 Genentech Inc Anticuerpos anti-mesotelina e inmunoconjugados
WO2014004549A2 (en) * 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
WO2014031476A1 (en) * 2012-08-21 2014-02-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mesothelin domain-specific monoclonal antibodies and use thereof
WO2014052064A1 (en) * 2012-09-27 2014-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mesothelin antibodies and methods for eliciting potent antitumor activity
CA2931684C (en) * 2013-12-19 2024-02-20 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof

Similar Documents

Publication Publication Date Title
RU2018107802A (ru) Полностью человеческие антитела к мезотелину и иммунные эффекторные клетки, нацеленные на мезотелин
JP2018522564A5 (enExample)
RU2018105963A (ru) Антитело против глипикана-3 и его применение
CN108884164B (zh) 用于免疫疗法的经修饰细胞
JP2018528786A5 (enExample)
CN105384825B (zh) 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP3250587B1 (en) Chimeric antigen receptors, compositions, and methods
JP2024500847A5 (enExample)
KR20230098158A (ko) Cd7 표적의 인간화 항체 및 이의 용도
RU2018104703A (ru) Опухолеспецифичное антитело против egfr и его применение
JP2015527070A5 (enExample)
CN115403671B (zh) 靶向Claudin18.2的纳米抗体及其用途
WO2022089353A1 (zh) 靶向bcma的单域抗体及其用途
CN114763385B (zh) 靶向ror1的抗体及其用途
JP2019503200A (ja) 癌の治療のための組成物及び方法
JP7064663B2 (ja) Il-13ra2を標的とする抗体及びその応用
JP2018526033A5 (enExample)
JP2019525771A5 (enExample)
CN115232209A (zh) 靶向gprc5d的抗体及其用途
JP2018536434A (ja) 腫瘍形質導入のための組成物及び方法
CN112638428A (zh) 嵌合抗原受体肿瘤浸润淋巴细胞
CN104829725A (zh) 一种双特异性抗体cd133×cd3的构建及应用
CN112041432A (zh) Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法
CN119613563A (zh) 编码car的核酸分子和含其的载体、car、含car的免疫细胞及其制造方法和含该细胞的医药组合物及提升细胞损伤活性的方法
KR20260017010A (ko) 장갑 항-b7h3 car-t 세포 및 암 치료에 있어서의 그 용도