CN106467573B - 抗间皮素全人抗体以及靶向间皮素的免疫效应细胞 - Google Patents

抗间皮素全人抗体以及靶向间皮素的免疫效应细胞 Download PDF

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CN106467573B
CN106467573B CN201610704504.0A CN201610704504A CN106467573B CN 106467573 B CN106467573 B CN 106467573B CN 201610704504 A CN201610704504 A CN 201610704504A CN 106467573 B CN106467573 B CN 106467573B
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antibody
seq
amino acid
acid sequence
mesothelin
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CN106467573A (zh
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王华茂
宋波
王鹏
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Kaixing Life Technology Shanghai Co ltd
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Cafa Therapeutics Ltd
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CN201610704504.0A 2015-08-21 2016-08-22 抗间皮素全人抗体以及靶向间皮素的免疫效应细胞 Active CN106467573B (zh)

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Families Citing this family (65)

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Publication number Priority date Publication date Assignee Title
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
HRP20191865T1 (hr) 2013-01-14 2020-01-10 Xencor, Inc. Novi heterodimerni proteini
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
EP3223907A2 (en) 2014-11-26 2017-10-04 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cd38
CN116333153A (zh) 2014-11-26 2023-06-27 森科股份有限公司 结合cd3和肿瘤抗原的异二聚体抗体
KR20190020341A (ko) 2016-06-28 2019-02-28 젠코어 인코포레이티드 소마토스타틴 수용체 2에 결합하는 이종이량체 항체
AU2018325842A1 (en) 2017-08-28 2020-04-16 Shanghai Yile Biotechnology Co, . Ltd. Polypeptide and antibody bound to polypeptide
CN107557336B (zh) * 2017-09-15 2020-02-14 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用
CN107488636A (zh) * 2017-09-30 2017-12-19 山东兴瑞生物科技有限公司 一种携带分子开关的抗her2嵌合抗原受体修饰的免疫细胞及其应用
KR101966362B1 (ko) 2017-10-20 2019-04-05 주식회사 녹십자 항-msln 항체 및 이를 포함하는 암 치료용 약학적 조성물
JP6339283B1 (ja) 2017-10-31 2018-06-06 国立大学法人 岡山大学 Dna、ポリペプチド、抗メソセリン抗体、腫瘍イメージング剤及び複合体
AU2018366199A1 (en) 2017-11-08 2020-05-28 Xencor, Inc. Bispecific and monospecific antibodies using novel anti-PD-1 sequences
CN109971714B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 自表达pd-1抗体并靶向间皮素的嵌合抗原受体修饰t细胞及其用途
CN109971717B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 共表达cd40抗体与间皮素特异性嵌合抗原受体的t细胞及其用途
CN109608549B (zh) * 2017-12-29 2022-02-18 郑州大学第一附属医院 基于人源间皮素抗体的嵌合抗原受体、慢病毒表达载体及其应用
WO2019149279A1 (zh) 2018-02-02 2019-08-08 科济生物医药(上海)有限公司 细胞免疫治疗的组合
AU2019231205A1 (en) * 2018-03-06 2020-09-24 The Trustees Of The University Of Pennsylvania Prostate-specific membrane antigen cars and methods of use thereof
CN111989344A (zh) 2018-03-09 2020-11-24 科济生物医药(上海)有限公司 用于治疗肿瘤的方法和组合物
EP3774906A1 (en) * 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Chimeric tim4 receptors and uses thereof
AU2019243154A1 (en) 2018-03-28 2020-10-01 Cero Therapeutics, Inc. Cellular immunotherapy compositions and uses thereof
CN112469477A (zh) 2018-04-04 2021-03-09 Xencor股份有限公司 与成纤维细胞活化蛋白结合的异源二聚体抗体
WO2019210863A1 (zh) 2018-05-03 2019-11-07 科济生物医药(上海)有限公司 免疫效应细胞及其应用
WO2019219029A1 (zh) 2018-05-15 2019-11-21 科济生物医药(上海)有限公司 基因工程化的细胞及应用
KR20210022004A (ko) * 2018-06-18 2021-03-02 안위타 바이오사이언시스, 인코포레이티드 항-메소텔린 작제물 및 이의 용도
CN112930199B (zh) 2018-07-24 2024-08-13 恺兴生命科技(上海)有限公司 免疫效应细胞治疗肿瘤的方法
CN109097396B (zh) * 2018-09-10 2022-10-11 上海细胞治疗集团有限公司 一种制备靶向间皮素的car-t细胞的方法
CN113164408B (zh) 2018-12-07 2025-07-22 克莱格医学有限公司 肿瘤联合免疫治疗
CN111381020B (zh) * 2018-12-27 2024-06-28 上海细胞治疗集团股份有限公司 一种间皮素car-t细胞免疫组化染色试剂盒及其应用
CN109666074B (zh) * 2018-12-29 2020-04-24 广州百暨基因科技有限公司 一种趋化因子受体cxcr5的用途
EP3909590A4 (en) 2019-01-07 2022-11-16 CRAGE medical Co., Limited ASSOCIATION FOR CELLULAR IMMUNOTHERAPY
CN109680004B (zh) * 2019-01-09 2025-03-21 上海美丽人生医疗科技有限公司 联合EpCAM和MSLN单链抗体的双靶点CAR载体及其构建方法和在卵巢癌中的应用
KR102070016B1 (ko) * 2019-01-21 2020-01-29 (주)녹십자셀 메소텔린 특이적인 키메라 항원 수용체 및 이를 발현하는 t 세포
JP2022523749A (ja) 2019-02-01 2022-04-26 クレージュ メディカル カンパニー,リミテッド Tcr融合タンパク質およびtcr融合タンパク質を発現する細胞
CN110055269B (zh) * 2019-03-20 2021-03-16 英威福赛生物技术有限公司 人间皮素嵌合抗原受体、其t细胞及其制备方法和用途
CA3141085A1 (en) * 2019-06-19 2020-12-24 Brenda Stevens Anti-mesothelin antibodies and immunoconjugates thereof
US20220106403A1 (en) * 2020-05-14 2022-04-07 Xencor, Inc. Heterodimeric antibodies that bind msln and cd3
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
US11795215B2 (en) 2020-08-04 2023-10-24 Cellengene Inc Anti-mesothelin chimeric antigen receptor specifically binding to mesothelin
WO2022030730A1 (ko) * 2020-08-04 2022-02-10 주식회사 셀렌진 메소텔린에 특이적으로 결합하는 항-메소텔린 키메릭 항원 수용체
WO2022028623A1 (zh) 2020-08-07 2022-02-10 佧珐药业有限公司 工程化改造的细胞以及工程化改造细胞的方法
WO2022078286A1 (zh) * 2020-10-15 2022-04-21 四川科伦博泰生物医药股份有限公司 特异性结合msln的嵌合抗原受体及其应用
JP2024511319A (ja) 2021-03-09 2024-03-13 ゼンコア インコーポレイテッド Cd3及びcldn6に結合するヘテロ二量体抗体
JP2024509274A (ja) 2021-03-10 2024-02-29 ゼンコア インコーポレイテッド Cd3及びgpc3に結合するヘテロ二量体抗体
WO2022214089A1 (zh) 2021-04-08 2022-10-13 克莱格医学有限公司 细胞免疫治疗的应用
CA3201255C (en) 2021-05-26 2023-11-14 Cellengene Inc Chimeric antigen receptor comprising anti-mesothelin scfv, and use thereof
US20250269028A1 (en) 2021-06-29 2025-08-28 Carsgen Therapeutics Co., Ltd Chimeric polypeptide for regulating cell physiological activity
KR102860436B1 (ko) * 2021-06-30 2025-09-19 (주)이노베이션바이오 메소텔린 특이적 항체 및 이의 용도
WO2023019396A1 (en) * 2021-08-16 2023-02-23 Utc Therapeutics (Shanghai) Co., Ltd. Mesothelin-targetting antibodies, chimeric antigen receptors, and uses thereof
CN113788896A (zh) * 2021-08-25 2021-12-14 南京蓝盾生物科技有限公司 抗msln单克隆内化抗体及其制备方法和应用
CN114015720A (zh) * 2021-09-29 2022-02-08 昆明市延安医院 具有靶向高强度杀瘤活性的Mesothelin嵌合抗原受体修饰的T细胞的制备方法
TW202321296A (zh) 2021-10-06 2023-06-01 美商鏈接免疫療法公司 抗間皮素抗原結合分子及其用途
CN118555970A (zh) * 2021-11-04 2024-08-27 总医院有限公司 抗间皮素抗体试剂
WO2023116637A1 (zh) * 2021-12-21 2023-06-29 深圳市菲鹏生物治疗股份有限公司 转基因免疫细胞及其构建方法和应用
CN116063530B (zh) * 2021-12-29 2023-09-29 华道(上海)生物医药有限公司 一种针对抗间皮素的抗体及其应用
CN118574646A (zh) * 2022-01-19 2024-08-30 上海优替济生生物医药有限公司 环状rna及其用途
CN119768429A (zh) * 2022-07-11 2025-04-04 诺纳生物(苏州)有限公司 抗间皮素抗体
EP4613771A1 (en) * 2022-11-02 2025-09-10 Cellengene Inc Chimeric antigen receptor with increased affinity for mesothelin and use thereof
KR20240081499A (ko) * 2022-11-11 2024-06-10 주식회사 유씨아이테라퓨틱스 유전자 조작된 세포 및 이의 용도
CN116003638B (zh) * 2023-01-20 2023-09-05 北京基因启明生物科技有限公司 一种有效杀伤胆管型肝癌的CAR-iNKT细胞技术
WO2025063790A1 (ko) * 2023-09-20 2025-03-27 주식회사 유씨아이테라퓨틱스 항-메소텔린 항체 및 이의 용도
CN117327184B (zh) * 2023-12-01 2024-03-05 赛奥斯博生物科技(北京)有限公司 一种靶向msln的嵌合抗原受体及其应用
CN117843793B (zh) * 2024-03-07 2024-07-09 深圳真实生物医药科技有限公司 抗间皮素抗体、抗原结合片段及其用途
WO2025195483A1 (en) * 2024-03-21 2025-09-25 Utc Therapeutics (Shanghai) Co., Ltd. Mesothelin targetting antibodies, chimeric antigen receptors, and uses thereof
CN119751681A (zh) * 2024-12-30 2025-04-04 北京百替生物技术有限公司 抗间皮素的单链抗体、mRNA及其应用和核酸药物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951946A (zh) * 2007-10-01 2011-01-19 百时美施贵宝公司 结合间皮素的人抗体及其应用
CN102458477A (zh) * 2009-04-29 2012-05-16 拜耳制药股份公司 抗-间皮素免疫缀合物及其应用
CN103347897A (zh) * 2010-12-20 2013-10-09 霍夫曼-拉罗奇有限公司 抗间皮素抗体和免疫偶联物
CN104151429A (zh) * 2007-11-26 2014-11-19 拜耳知识产权有限责任公司 抗-间皮素抗体及其用途
WO2015090230A1 (en) * 2013-12-19 2015-06-25 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
ES2429340T3 (es) * 2005-03-10 2013-11-14 Morphotek, Inc. Anticuerpos anti-mesotelina
US8357783B2 (en) 2008-03-27 2013-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human anti-mesothelin monoclonal antibodies
AU2010230063B2 (en) 2009-03-24 2015-06-25 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anti-mesothelin antibodies
WO2014004549A2 (en) * 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
CA2882753C (en) 2012-08-21 2021-08-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mesothelin domain-specific monoclonal antibodies and use thereof
AU2013324049B2 (en) 2012-09-27 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mesothelin antibodies and methods for eliciting potent antitumor activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101951946A (zh) * 2007-10-01 2011-01-19 百时美施贵宝公司 结合间皮素的人抗体及其应用
CN104151429A (zh) * 2007-11-26 2014-11-19 拜耳知识产权有限责任公司 抗-间皮素抗体及其用途
CN102458477A (zh) * 2009-04-29 2012-05-16 拜耳制药股份公司 抗-间皮素免疫缀合物及其应用
CN103347897A (zh) * 2010-12-20 2013-10-09 霍夫曼-拉罗奇有限公司 抗间皮素抗体和免疫偶联物
WO2015090230A1 (en) * 2013-12-19 2015-06-25 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAR-T细胞在肿瘤治疗中的研究进展;赵玲娣等;《中国肿瘤临床》;20150215;第42卷(第3期);第190-194页 *
Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor;Edmund K. Moon等;《Clinical cancer research》;20110731;第17卷(第14期);第4719-4730页 *
Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity;Prasad S. Adusumilli等;《Sci Transl Med》;20141105;第6卷(第261期);第1-31页 *

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