JP6994456B2 - 抗メソテリン完全ヒト抗体およびメソテリンを標的とする免疫エフェクター細胞 - Google Patents
抗メソテリン完全ヒト抗体およびメソテリンを標的とする免疫エフェクター細胞 Download PDFInfo
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- JP6994456B2 JP6994456B2 JP2018509805A JP2018509805A JP6994456B2 JP 6994456 B2 JP6994456 B2 JP 6994456B2 JP 2018509805 A JP2018509805 A JP 2018509805A JP 2018509805 A JP2018509805 A JP 2018509805A JP 6994456 B2 JP6994456 B2 JP 6994456B2
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- A—HUMAN NECESSITIES
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510519214 | 2015-08-21 | ||
| CN201510519214.4 | 2015-08-21 | ||
| PCT/CN2016/096292 WO2017032293A1 (zh) | 2015-08-21 | 2016-08-22 | 抗间皮素全人抗体以及靶向间皮素的免疫效应细胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529327A JP2018529327A (ja) | 2018-10-11 |
| JP2018529327A5 JP2018529327A5 (enExample) | 2019-10-03 |
| JP6994456B2 true JP6994456B2 (ja) | 2022-02-04 |
Family
ID=58099641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018509805A Expired - Fee Related JP6994456B2 (ja) | 2015-08-21 | 2016-08-22 | 抗メソテリン完全ヒト抗体およびメソテリンを標的とする免疫エフェクター細胞 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10793641B2 (enExample) |
| EP (1) | EP3339326A4 (enExample) |
| JP (1) | JP6994456B2 (enExample) |
| KR (1) | KR20180055824A (enExample) |
| CN (1) | CN106467573B (enExample) |
| AU (1) | AU2016312015A1 (enExample) |
| BR (1) | BR112018003339A8 (enExample) |
| CA (1) | CA2996060A1 (enExample) |
| CL (1) | CL2018000457A1 (enExample) |
| HK (1) | HK1251948A1 (enExample) |
| IL (1) | IL257563A (enExample) |
| NZ (1) | NZ740855A (enExample) |
| RU (1) | RU2748281C2 (enExample) |
| SG (1) | SG11201801351RA (enExample) |
| WO (1) | WO2017032293A1 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| HRP20191865T1 (hr) | 2013-01-14 | 2020-01-10 | Xencor, Inc. | Novi heterodimerni proteini |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| EP3223907A2 (en) | 2014-11-26 | 2017-10-04 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
| CN116333153A (zh) | 2014-11-26 | 2023-06-27 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| KR20190020341A (ko) | 2016-06-28 | 2019-02-28 | 젠코어 인코포레이티드 | 소마토스타틴 수용체 2에 결합하는 이종이량체 항체 |
| AU2018325842A1 (en) | 2017-08-28 | 2020-04-16 | Shanghai Yile Biotechnology Co, . Ltd. | Polypeptide and antibody bound to polypeptide |
| CN107557336B (zh) * | 2017-09-15 | 2020-02-14 | 山东兴瑞生物科技有限公司 | 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用 |
| CN107488636A (zh) * | 2017-09-30 | 2017-12-19 | 山东兴瑞生物科技有限公司 | 一种携带分子开关的抗her2嵌合抗原受体修饰的免疫细胞及其应用 |
| KR101966362B1 (ko) | 2017-10-20 | 2019-04-05 | 주식회사 녹십자 | 항-msln 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
| JP6339283B1 (ja) | 2017-10-31 | 2018-06-06 | 国立大学法人 岡山大学 | Dna、ポリペプチド、抗メソセリン抗体、腫瘍イメージング剤及び複合体 |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| CN109971714B (zh) * | 2017-12-28 | 2023-06-20 | 上海细胞治疗研究院 | 自表达pd-1抗体并靶向间皮素的嵌合抗原受体修饰t细胞及其用途 |
| CN109971717B (zh) * | 2017-12-28 | 2023-06-20 | 上海细胞治疗研究院 | 共表达cd40抗体与间皮素特异性嵌合抗原受体的t细胞及其用途 |
| CN109608549B (zh) * | 2017-12-29 | 2022-02-18 | 郑州大学第一附属医院 | 基于人源间皮素抗体的嵌合抗原受体、慢病毒表达载体及其应用 |
| WO2019149279A1 (zh) | 2018-02-02 | 2019-08-08 | 科济生物医药(上海)有限公司 | 细胞免疫治疗的组合 |
| AU2019231205A1 (en) * | 2018-03-06 | 2020-09-24 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
| CN111989344A (zh) | 2018-03-09 | 2020-11-24 | 科济生物医药(上海)有限公司 | 用于治疗肿瘤的方法和组合物 |
| EP3774906A1 (en) * | 2018-03-28 | 2021-02-17 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
| AU2019243154A1 (en) | 2018-03-28 | 2020-10-01 | Cero Therapeutics, Inc. | Cellular immunotherapy compositions and uses thereof |
| CN112469477A (zh) | 2018-04-04 | 2021-03-09 | Xencor股份有限公司 | 与成纤维细胞活化蛋白结合的异源二聚体抗体 |
| WO2019210863A1 (zh) | 2018-05-03 | 2019-11-07 | 科济生物医药(上海)有限公司 | 免疫效应细胞及其应用 |
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| CN112930199B (zh) | 2018-07-24 | 2024-08-13 | 恺兴生命科技(上海)有限公司 | 免疫效应细胞治疗肿瘤的方法 |
| CN109097396B (zh) * | 2018-09-10 | 2022-10-11 | 上海细胞治疗集团有限公司 | 一种制备靶向间皮素的car-t细胞的方法 |
| CN113164408B (zh) | 2018-12-07 | 2025-07-22 | 克莱格医学有限公司 | 肿瘤联合免疫治疗 |
| CN111381020B (zh) * | 2018-12-27 | 2024-06-28 | 上海细胞治疗集团股份有限公司 | 一种间皮素car-t细胞免疫组化染色试剂盒及其应用 |
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| KR102070016B1 (ko) * | 2019-01-21 | 2020-01-29 | (주)녹십자셀 | 메소텔린 특이적인 키메라 항원 수용체 및 이를 발현하는 t 세포 |
| JP2022523749A (ja) | 2019-02-01 | 2022-04-26 | クレージュ メディカル カンパニー,リミテッド | Tcr融合タンパク質およびtcr融合タンパク質を発現する細胞 |
| CN110055269B (zh) * | 2019-03-20 | 2021-03-16 | 英威福赛生物技术有限公司 | 人间皮素嵌合抗原受体、其t细胞及其制备方法和用途 |
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- 2016-08-22 CN CN201610704504.0A patent/CN106467573B/zh active Active
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- 2016-08-22 NZ NZ740855A patent/NZ740855A/en not_active IP Right Cessation
- 2016-08-22 KR KR1020187007893A patent/KR20180055824A/ko not_active Ceased
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- 2016-08-22 WO PCT/CN2016/096292 patent/WO2017032293A1/zh not_active Ceased
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| NZ740855A (en) | 2022-04-29 |
| RU2748281C2 (ru) | 2021-05-21 |
| RU2018107802A (ru) | 2019-09-23 |
| CN106467573B (zh) | 2021-05-25 |
| US20180244796A1 (en) | 2018-08-30 |
| CL2018000457A1 (es) | 2018-08-24 |
| JP2018529327A (ja) | 2018-10-11 |
| IL257563A (en) | 2018-04-30 |
| EP3339326A1 (en) | 2018-06-27 |
| HK1251948A1 (en) | 2019-05-03 |
| BR112018003339A8 (pt) | 2022-10-18 |
| SG11201801351RA (en) | 2018-03-28 |
| KR20180055824A (ko) | 2018-05-25 |
| US10793641B2 (en) | 2020-10-06 |
| CN106467573A (zh) | 2017-03-01 |
| CA2996060A1 (en) | 2017-03-02 |
| RU2018107802A3 (enExample) | 2019-09-23 |
| AU2016312015A1 (en) | 2018-04-12 |
| EP3339326A4 (en) | 2019-01-09 |
| WO2017032293A1 (zh) | 2017-03-02 |
| BR112018003339A2 (pt) | 2018-11-21 |
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