JP2020503891A5 - - Google Patents
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- JP2020503891A5 JP2020503891A5 JP2019551736A JP2019551736A JP2020503891A5 JP 2020503891 A5 JP2020503891 A5 JP 2020503891A5 JP 2019551736 A JP2019551736 A JP 2019551736A JP 2019551736 A JP2019551736 A JP 2019551736A JP 2020503891 A5 JP2020503891 A5 JP 2020503891A5
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- JP
- Japan
- Prior art keywords
- seq
- cells
- cell
- car
- cell according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 16
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 15
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 15
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 11
- 210000000822 natural killer cell Anatomy 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 102000009058 Death Domain Receptors Human genes 0.000 claims 1
- 108010049207 Death Domain Receptors Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102000003800 Selectins Human genes 0.000 claims 1
- 108090000184 Selectins Proteins 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023017202A JP2023052980A (ja) | 2016-12-09 | 2023-02-07 | 操作されたナチュラルキラー細胞およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662432302P | 2016-12-09 | 2016-12-09 | |
| US62/432,302 | 2016-12-09 | ||
| PCT/EP2017/082292 WO2018104562A1 (en) | 2016-12-09 | 2017-12-11 | Engineered natural killer cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023017202A Division JP2023052980A (ja) | 2016-12-09 | 2023-02-07 | 操作されたナチュラルキラー細胞およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503891A JP2020503891A (ja) | 2020-02-06 |
| JP2020503891A5 true JP2020503891A5 (enExample) | 2021-01-21 |
| JP7228900B2 JP7228900B2 (ja) | 2023-02-27 |
Family
ID=60937693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551736A Active JP7228900B2 (ja) | 2016-12-09 | 2017-12-11 | 操作されたナチュラルキラー細胞およびその使用 |
| JP2023017202A Pending JP2023052980A (ja) | 2016-12-09 | 2023-02-07 | 操作されたナチュラルキラー細胞およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023017202A Pending JP2023052980A (ja) | 2016-12-09 | 2023-02-07 | 操作されたナチュラルキラー細胞およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10799536B2 (enExample) |
| EP (4) | EP3581190B1 (enExample) |
| JP (2) | JP7228900B2 (enExample) |
| KR (1) | KR20190114966A (enExample) |
| CN (2) | CN110248669B (enExample) |
| AU (1) | AU2017371517B2 (enExample) |
| BR (1) | BR112019011450A2 (enExample) |
| CA (1) | CA3045386A1 (enExample) |
| DK (2) | DK3454871T3 (enExample) |
| ES (3) | ES2926397T3 (enExample) |
| MX (1) | MX2019006598A (enExample) |
| WO (1) | WO2018104562A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| GB2567362B (en) * | 2016-07-15 | 2022-04-20 | Nantkwest Inc | HDAC inhibitors for use with NK cell based therapies |
| ES2926397T3 (es) * | 2016-12-09 | 2022-10-26 | Onk Therapeutics Ltd | Células asesinas naturales manipuladas y usos de las mismas |
| KR102846479B1 (ko) * | 2018-05-16 | 2025-08-18 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | Cas9 리보핵단백질을 사용하는 녹아웃 일차 및 확장된 인간 nk 세포의 생성 |
| EP3829605A4 (en) * | 2018-08-01 | 2022-10-19 | ImmunityBio, Inc. | QUADRICISTRONIC SYSTEM COMPRISING A homing or CYTOKINE RECEPTOR, AND CHIMERIC ANTIGEN RECEPTOR FOR GENETIC MODIFICATION OF IMMUNOTHERAPIES |
| TWI785268B (zh) * | 2018-08-29 | 2022-12-01 | 中央研究院 | 用於治療癌症的自然殺手細胞與環磷醯胺的組合 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR102292657B1 (ko) | 2019-03-15 | 2021-08-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| WO2020189942A1 (ko) * | 2019-03-15 | 2020-09-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| CN109970869A (zh) * | 2019-04-12 | 2019-07-05 | 南京卡提医学科技有限公司 | 一种靶向人trail死亡受体的嵌合受体配体及其应用 |
| WO2020220027A1 (en) * | 2019-04-25 | 2020-10-29 | Purdue Research Foundation | Engineered natural killer cells redirected toward purinergic signaling, constructs thereof, and methods for using the same |
| KR20220093337A (ko) * | 2019-10-31 | 2022-07-05 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | Cd38 녹아웃 일차 및 확장된 인간 nk 세포의 생성 |
| US20230036481A1 (en) * | 2020-01-16 | 2023-02-02 | Acepodia Biotechnologies Ltd. | A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| WO2021209625A1 (en) * | 2020-04-17 | 2021-10-21 | Onk Therapeutics Limited | High potency natural killer cells |
| JP7607749B2 (ja) * | 2020-08-27 | 2024-12-27 | 株式会社 セリッド | 新規コロナウイルス組換えスパイクタンパク質、それをコードするポリヌクレオチド、ポリヌクレオチドを含むベクター、およびベクターを含む、コロナウイルス感染を予防または処置するためのワクチン |
| WO2022047419A1 (en) | 2020-08-31 | 2022-03-03 | City Of Hope | Novel cell lines, methods of producing natural killer cells and uses thereof |
| CN114426583B (zh) * | 2020-10-29 | 2023-10-10 | 中国科学技术大学 | 用于急性髓系白血病的细胞疗法的嵌合抗原受体 |
| KR20220091426A (ko) * | 2020-12-23 | 2022-06-30 | 주식회사 휴먼셀바이오 | 혈액 유래 물질 및 면역세포를 포함하는 암 또는 면역질환의 예방 또는 치료용 약학조성물 |
| JP2024522756A (ja) | 2021-06-18 | 2024-06-21 | オーエヌケイ セラピューティクス リミテッド | ダブルノックアウトナチュラルキラー細胞 |
| AU2022301302A1 (en) | 2021-07-01 | 2024-01-25 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and related methods |
| WO2023010038A1 (en) * | 2021-07-29 | 2023-02-02 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Synthetic nucleic acid elements for enhancing car t cell efficacy |
| CA3231204A1 (en) * | 2021-09-18 | 2023-03-23 | Feng Wang-Johanning | Herv-k antibody, cell, vaccine, and drug therapeutics |
| US20240352123A1 (en) * | 2021-12-03 | 2024-10-24 | University Of Utah Research Foundation | High selective cd229 antigen binding domains and methods of use |
| CA3259982A1 (en) | 2022-06-30 | 2024-01-04 | Indapta Therapeutics, Inc. | COMBINATION OF MODIFIED NATURAL KILLER (NK) CELLS AND ANTIBODY THERAPY AND ASSOCIATED METHODS |
| EP4353741A1 (en) | 2022-10-14 | 2024-04-17 | ONK Therapeutics Limited | Double knockout natural killer cells |
| CN120091827A (zh) | 2022-11-10 | 2025-06-03 | 昂克医疗有限公司 | 使用免疫调节药物的联合疗法 |
| WO2024238387A1 (en) * | 2023-05-12 | 2024-11-21 | Nkmax Co., Ltd. | Method of treating alzheimer's disease with expanded natural killer cells |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025073908A1 (en) | 2023-10-05 | 2025-04-10 | Onk Therapeutics Limited | Optimised il-15 constructs |
| WO2025146467A1 (en) | 2024-01-04 | 2025-07-10 | Onk Therapeutics Limited | Targeted il-15 construct delivery |
| KR20250118299A (ko) | 2024-01-29 | 2025-08-06 | 인하대학교 산학협력단 | 전기자극 시스템을 활용한 자연살해세포의 암세포 살상 능력 증진 방법 |
| WO2025184169A1 (en) * | 2024-02-26 | 2025-09-04 | The Regents Of The University Of California | Oleate-mediated enhancement of human natural killer cell function |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004213432A1 (en) * | 2003-02-14 | 2004-09-02 | Sagres Discovery, Inc. | Novel therapeutic targets in cancer |
| MX2007011064A (es) | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| TR201910145T4 (tr) | 2006-09-26 | 2019-08-21 | Genmab As | Tümörlerin tedavi edilmesine yönelik anti-CD38 artı kortikosteroidler artı bir kortikosteroid-olmayan kemoterapötik. |
| AU2007311002B2 (en) | 2006-10-19 | 2012-01-12 | Csl Limited | Antibody antagonists of interleukin-13 receptor alpha 1 |
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| EP2580243B1 (en) * | 2010-06-09 | 2019-10-16 | Genmab A/S | Antibodies against human cd38 |
| WO2014138704A1 (en) | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Targeting cd138 in cancer |
| US10934346B2 (en) * | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| EP3505623B1 (en) * | 2014-02-14 | 2025-12-24 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| PL3237436T3 (pl) | 2014-12-24 | 2020-03-31 | Aadigen, Llc | Peptydy i nanocząsteczki do wewnątrzkomórkowego dostarczania cząsteczek |
| JP6797803B2 (ja) * | 2014-12-31 | 2020-12-09 | セルジーン コーポレイション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| CN108603170A (zh) | 2015-06-12 | 2018-09-28 | 莱蒂恩技术公司 | 用工程改造的t细胞治疗癌症的方法 |
| WO2016210293A1 (en) | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| EP3317401B1 (en) | 2015-07-29 | 2018-10-03 | Onkimmune Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| CN105384825B (zh) | 2015-08-11 | 2018-06-01 | 南京传奇生物科技有限公司 | 一种基于单域抗体的双特异性嵌合抗原受体及其应用 |
| ES2926397T3 (es) | 2016-12-09 | 2022-10-26 | Onk Therapeutics Ltd | Células asesinas naturales manipuladas y usos de las mismas |
-
2017
- 2017-12-11 ES ES21160170T patent/ES2926397T3/es active Active
- 2017-12-11 WO PCT/EP2017/082292 patent/WO2018104562A1/en not_active Ceased
- 2017-12-11 EP EP19176141.0A patent/EP3581190B1/en active Active
- 2017-12-11 ES ES17825774T patent/ES2746856T3/es active Active
- 2017-12-11 EP EP22179362.3A patent/EP4104841A1/en active Pending
- 2017-12-11 ES ES19176141T patent/ES2875005T3/es active Active
- 2017-12-11 AU AU2017371517A patent/AU2017371517B2/en active Active
- 2017-12-11 EP EP17825774.7A patent/EP3454871B1/en active Active
- 2017-12-11 KR KR1020197019363A patent/KR20190114966A/ko not_active Ceased
- 2017-12-11 EP EP21160170.3A patent/EP3895712B1/en active Active
- 2017-12-11 BR BR112019011450A patent/BR112019011450A2/pt not_active IP Right Cessation
- 2017-12-11 MX MX2019006598A patent/MX2019006598A/es unknown
- 2017-12-11 CA CA3045386A patent/CA3045386A1/en active Pending
- 2017-12-11 DK DK17825774.7T patent/DK3454871T3/da active
- 2017-12-11 CN CN201780085686.0A patent/CN110248669B/zh active Active
- 2017-12-11 JP JP2019551736A patent/JP7228900B2/ja active Active
- 2017-12-11 DK DK19176141.0T patent/DK3581190T3/da active
- 2017-12-11 CN CN202311063691.5A patent/CN117305250A/zh active Pending
- 2017-12-11 US US15/837,576 patent/US10799536B2/en active Active
-
2020
- 2020-08-31 US US17/008,506 patent/US20210046118A1/en active Pending
-
2023
- 2023-02-07 JP JP2023017202A patent/JP2023052980A/ja active Pending
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