JP2015535691A5 - - Google Patents

Info

Publication number

JP2015535691A5

JP2015535691A5 JP2015535829A JP2015535829A JP2015535691A5 JP 2015535691 A5 JP2015535691 A5 JP 2015535691A5 JP 2015535829 A JP2015535829 A JP 2015535829A JP 2015535829 A JP2015535829 A JP 2015535829A JP 2015535691 A5 JP2015535691 A5 JP 2015535691A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

cdrs

nucleotide sequence

Prior art date

2013-10-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 85
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims description 2
• 102000048776 human CD274 Human genes 0.000 claims description 2
• 239000002773 nucleotide Substances 0.000 claims 28
• 125000003729 nucleotide group Chemical group 0.000 claims 28
• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 239000000427 antigen Substances 0.000 claims 11
• 102000036639 antigens Human genes 0.000 claims 11
• 108091007433 antigens Proteins 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims 5
• 208000036142 Viral infection Diseases 0.000 claims 4
• 150000007523 nucleic acids Chemical group 0.000 claims 4
• 230000009385 viral infection Effects 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 230000001684 chronic effect Effects 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
• 108700012439 CA9 Proteins 0.000 claims 2
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 2
• 108010001857 Cell Surface Receptors Proteins 0.000 claims 2
• 102000000844 Cell Surface Receptors Human genes 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
• 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000004540 complement-dependent cytotoxicity Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 210000004881 tumor cell Anatomy 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
• 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
• 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
• 102000004527 Interleukin-21 Receptors Human genes 0.000 claims 1
• 108010017411 Interleukin-21 Receptors Proteins 0.000 claims 1
• 102000012220 Member 14 Tumor Necrosis Factor Receptors Human genes 0.000 claims 1
• 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 102000003675 cytokine receptors Human genes 0.000 claims 1
• 108010057085 cytokine receptors Proteins 0.000 claims 1
• 210000003162 effector t lymphocyte Anatomy 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 1