JP2017535284A5 - - Google Patents
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- JP2017535284A5 JP2017535284A5 JP2017543315A JP2017543315A JP2017535284A5 JP 2017535284 A5 JP2017535284 A5 JP 2017535284A5 JP 2017543315 A JP2017543315 A JP 2017543315A JP 2017543315 A JP2017543315 A JP 2017543315A JP 2017535284 A5 JP2017535284 A5 JP 2017535284A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- car
- antigen
- apc
- car polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 47
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 239000000427 antigen Substances 0.000 claims description 30
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- 102000036639 antigens Human genes 0.000 claims description 30
- 210000004027 cell Anatomy 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 14
- 230000002438 mitochondrial effect Effects 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 230000035772 mutation Effects 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 108700008625 Reporter Genes Proteins 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 108700019146 Transgenes Proteins 0.000 claims description 6
- 230000003834 intracellular effect Effects 0.000 claims description 6
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 4
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 4
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 4
- 230000005754 cellular signaling Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 230000000241 respiratory effect Effects 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 102000009109 Fc receptors Human genes 0.000 claims description 2
- 108010087819 Fc receptors Proteins 0.000 claims description 2
- 210000000173 T-lymphoid precursor cell Anatomy 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 239000012642 immune effector Substances 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000004068 intracellular signaling Effects 0.000 claims description 2
- 210000000265 leukocyte Anatomy 0.000 claims description 2
- 230000025608 mitochondrion localization Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 6
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 101100065514 Mus musculus Eral1 gene Proteins 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462075561P | 2014-11-05 | 2014-11-05 | |
| US201462075642P | 2014-11-05 | 2014-11-05 | |
| US201462075667P | 2014-11-05 | 2014-11-05 | |
| US62/075,642 | 2014-11-05 | ||
| US62/075,667 | 2014-11-05 | ||
| US62/075,561 | 2014-11-05 | ||
| US201562169979P | 2015-06-02 | 2015-06-02 | |
| US62/169,979 | 2015-06-02 | ||
| PCT/US2015/059293 WO2016073755A2 (en) | 2014-11-05 | 2015-11-05 | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019203260A Division JP2020022504A (ja) | 2014-11-05 | 2019-11-08 | 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017535284A JP2017535284A (ja) | 2017-11-30 |
| JP2017535284A5 true JP2017535284A5 (enExample) | 2018-12-13 |
Family
ID=54548288
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543315A Withdrawn JP2017535284A (ja) | 2014-11-05 | 2015-11-05 | 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 |
| JP2019203260A Pending JP2020022504A (ja) | 2014-11-05 | 2019-11-08 | 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019203260A Pending JP2020022504A (ja) | 2014-11-05 | 2019-11-08 | 免疫エフェクター細胞の拡大のための遺伝子改変免疫エフェクター細胞及び遺伝子操作細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20170333480A1 (enExample) |
| EP (2) | EP3536707A1 (enExample) |
| JP (2) | JP2017535284A (enExample) |
| KR (1) | KR20170075785A (enExample) |
| CN (1) | CN107207615A (enExample) |
| AU (2) | AU2015343013B2 (enExample) |
| CA (1) | CA2964785A1 (enExample) |
| HK (1) | HK1243441A1 (enExample) |
| WO (1) | WO2016073755A2 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| CN105408473B9 (zh) | 2013-05-14 | 2021-09-17 | 得克萨斯州大学系统董事会 | 工程化嵌合抗原受体(car)t细胞的人应用 |
| HK1223943A1 (zh) | 2013-05-24 | 2017-08-11 | Board Of Regents, The University Of Texas System | 嵌合的靶向抗原受体的单克隆抗体 |
| WO2015123642A1 (en) | 2014-02-14 | 2015-08-20 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors and methods of making |
| SG11201609118RA (en) | 2014-05-15 | 2016-11-29 | Univ Singapore | Modified natural killer cells and uses thereof |
| CA2964783C (en) | 2014-11-05 | 2024-01-23 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| WO2016100233A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| EP3240805B1 (en) | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| CN107667169B (zh) | 2015-02-24 | 2021-10-29 | 得克萨斯州大学系统董事会 | 遗传修饰的t细胞的选择方法 |
| WO2016145146A1 (en) | 2015-03-11 | 2016-09-15 | Board Of Regents, The University Of Texas System | Transposase polypeptides and uses thereof |
| US10633445B2 (en) | 2015-09-15 | 2020-04-28 | Board Of Regents The University Of Texas System | T-cell receptor (TCR)-binding antibodies and uses thereof |
| US11059879B2 (en) | 2015-10-27 | 2021-07-13 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| EP3468994A1 (en) | 2016-06-08 | 2019-04-17 | Intrexon Corporation | Cd33 specific chimeric antigen receptors |
| EP4353750A3 (en) * | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| CN106117366A (zh) * | 2016-06-24 | 2016-11-16 | 安徽未名细胞治疗有限公司 | 一种cd19特异性嵌合抗原受体及其编码基因、应用 |
| KR20190057308A (ko) | 2016-09-02 | 2019-05-28 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물 |
| US11219646B2 (en) * | 2016-09-30 | 2022-01-11 | Baylor College Of Medicine | Chimeric antigen receptor therapy with reduced cytotoxicity for viral disease |
| FI3535290T3 (fi) * | 2016-11-07 | 2024-02-05 | Genovie Ab | Keinotekoinen kaksiosainen solulaite T-solun reseptorin vuorovaikutuksen havaitsemiseksi ja luonnehtimiseksi kognaattiantigeenin kanssa |
| ES2968633T3 (es) * | 2016-11-07 | 2024-05-13 | Genovie Ab | Sistema multicomponente modificado por ingeniería para la identificación y caracterización de receptores de linfocitos T y antígenos de linfocitos T |
| US11274309B2 (en) | 2016-11-07 | 2022-03-15 | Genovie Ab | Two-part device for T-cell receptor synthesis and stable genomic integration to TCR-presenting cells |
| CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| JP7288401B2 (ja) | 2017-01-10 | 2023-06-07 | プレシゲン，インコーポレイテッド | 新規の遺伝子スイッチ発現系を介したポリペプチドの発現のモジュレーション |
| CN108424458A (zh) * | 2017-02-13 | 2018-08-21 | 上海恒润达生生物科技有限公司 | 靶向ny-eso-1的嵌合抗原受体及其用途 |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための組成物および方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN110636851B (zh) | 2017-03-27 | 2023-11-03 | 新加坡国立大学 | 截短的nkg2d嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| RU2019128544A (ru) | 2017-03-27 | 2021-04-28 | Нэшнл Юниверсити Оф Сингапур | Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров |
| ES2905377T3 (es) * | 2017-04-18 | 2022-04-08 | Autolus Ltd | Célula |
| AU2018281316B2 (en) | 2017-06-07 | 2024-05-30 | Precigen, Inc. | Expression of novel cell tags |
| EP3658163A4 (en) * | 2017-07-25 | 2021-08-04 | Board Of Regents, The University Of Texas System | IMPROVED ANTIGENIC CHEMICAL RECEPTORS AND THEIR USES |
| GB201713078D0 (en) * | 2017-08-15 | 2017-09-27 | Adaptimmune Ltd | T Cell Modification |
| JP7391015B2 (ja) * | 2017-09-29 | 2023-12-04 | アメリカ合衆国 | Ｐ５３がん特異的変異に対して抗原特異性を有するｔ細胞を単離する方法 |
| EP3710471A1 (en) * | 2017-11-16 | 2020-09-23 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| CN108103106A (zh) * | 2018-01-09 | 2018-06-01 | 河南省华隆生物技术有限公司 | 一种pFTM3GW重组载体及其制备方法和应用 |
| CA3089319A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| CN110093351B (zh) * | 2018-01-29 | 2023-06-23 | 华南生物医药研究院 | 可分离的核酸、多肽、重组载体、重组细胞及应用 |
| EP4656653A3 (en) | 2018-02-09 | 2025-12-17 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Tethered interleukin-15 and interleukin-21 |
| CA3089170A1 (en) * | 2018-02-09 | 2019-08-15 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| WO2019182425A1 (ko) * | 2018-03-23 | 2019-09-26 | 주식회사 에스엘바이젠 | 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도 |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CA3103610A1 (en) * | 2018-06-12 | 2019-12-19 | The Regents Of The University Of California | Single-chain bispecific chimeric antigen receptors for the treatment of cancer |
| EP3815711A4 (en) * | 2018-06-29 | 2022-08-10 | Taiho Pharmaceutical Co., Ltd. | ANTITUMOR AGENT AND ITS METHOD OF EVALUATION |
| US12391739B2 (en) * | 2018-07-13 | 2025-08-19 | Kyoto University | Method for producing gamma delta T cells |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US20210317184A1 (en) * | 2018-09-05 | 2021-10-14 | GlaxoSmithKline Intellectual Property Devolopment Limited | T cell modification |
| WO2020085480A1 (ja) * | 2018-10-26 | 2020-04-30 | キッセイ薬品工業株式会社 | 高効率な遺伝子改変細胞の作製方法 |
| CN111378046B (zh) * | 2018-12-27 | 2024-03-15 | 上海细胞治疗集团有限公司 | 一种免疫效应细胞转换受体 |
| WO2020163755A1 (en) * | 2019-02-08 | 2020-08-13 | Dna Twopointo Inc. | Transposon-based modifications of immune cells |
| CN111544585B (zh) * | 2019-02-11 | 2024-12-27 | 北京卡替医疗技术有限公司 | 一种可助推免疫细胞在体内扩增的佐剂 |
| US20220169695A1 (en) * | 2019-03-04 | 2022-06-02 | University Health Network | T cell receptors and methods of use thereof |
| SG11202109057XA (en) * | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JP2022527081A (ja) * | 2019-03-26 | 2022-05-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血液がんおよび固形がんの治療のためのキメラ抗原受容体改変ｔ細胞（ｃａｒ－ｔ） |
| WO2021019706A1 (ja) * | 2019-07-31 | 2021-02-04 | 国立大学法人信州大学 | Ｃａｒ発現免疫細胞を含む細胞集団の製造方法 |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| WO2021100585A1 (ja) * | 2019-11-20 | 2021-05-27 | 国立大学法人東海国立大学機構 | キメラ抗原受容体遺伝子改変リンパ球の調製方法 |
| GB201918908D0 (en) * | 2019-12-19 | 2020-02-05 | Autolus Ltd | Cell |
| CN111264469B (zh) * | 2020-02-27 | 2022-03-25 | 西安交通大学医学院第一附属医院 | 一种基因免疫诱导的甲状腺相关性眼病动物模型的构建方法及雷帕霉素类药物的应用 |
| EP4127141A1 (en) * | 2020-04-03 | 2023-02-08 | Cellvie Inc. | Enhancement of adoptive cell transfer |
| JP2023537048A (ja) | 2020-08-07 | 2023-08-30 | ネオジン セラピューティクス ビー．ブイ． | 遺伝子改変したｔ細胞の濃縮方法 |
| BR112023014436A2 (pt) * | 2021-01-20 | 2023-10-31 | Neogene Therapeutics B V | Células apresentadoras de antígenos manipuladas |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| EP4589005A1 (en) * | 2022-09-13 | 2025-07-23 | Cyto-Facto Inc. | T cells for transplantation and production method thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| DE69435010T2 (de) * | 1993-04-20 | 2008-04-30 | Hipler Partners Llp | Verfahren und stoffe für die behandlung von individuen, die infiziert sind mit intrazellulär infektiösen agentien |
| US6461867B1 (en) | 1995-03-08 | 2002-10-08 | The Scripps Research Institute | Synthetic antigen presenting matrix |
| AU723355B2 (en) | 1996-05-23 | 2000-08-24 | Scripps Research Institute, The | MHC class II antigen presenting systems and methods for activating CD4+ T cells |
| KR20000076157A (ko) | 1997-03-11 | 2000-12-26 | 리전츠 오브 더 유니버스티 오브 미네소타 | 세포의 디엔에이로 핵산을 도입하는 디엔에이-기초 전이인자 시스템 |
| WO1999047687A1 (en) * | 1998-03-20 | 1999-09-23 | Genzyme Corporation | Enhanced anti-tumor immunity |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US6790662B1 (en) | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| US7955845B2 (en) * | 2001-11-20 | 2011-06-07 | Dana Farber Cancer Institute, Inc. | Modified antigen-presenting cells |
| AU2003231048A1 (en) | 2002-04-22 | 2003-11-03 | Regents Of The University Of Minnesota | Transposon system and methods of use |
| JP4733635B2 (ja) | 2003-07-31 | 2011-07-27 | イミューノメディクス、インコーポレイテッド | 抗ｃｄ１９抗体 |
| US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| EP2327763B1 (en) * | 2005-08-05 | 2018-03-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Generation of antigen specific T cells |
| CA2643337C (en) | 2006-03-01 | 2016-01-12 | Janssen Pharmaceutica N.V. | Cancer treatment combining lymphodepleting agent with ctls and cytokines |
| US8124408B2 (en) | 2006-10-04 | 2012-02-28 | Janssen Pharmaceutica N.V. | Preparation of inactivated artificial antigen presenting cells and their use in cell therapies |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| AR075896A1 (es) | 2009-03-20 | 2011-05-04 | Genentech Inc | Anticuerpos anti-her (factor de crecimiento epidermico) |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2768863B1 (en) | 2011-10-20 | 2017-09-27 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd22 chimeric antigen receptors |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| HK1223943A1 (zh) | 2013-05-24 | 2017-08-11 | Board Of Regents, The University Of Texas System | 嵌合的靶向抗原受体的单克隆抗体 |
| WO2015123642A1 (en) | 2014-02-14 | 2015-08-20 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors and methods of making |
-
2015
- 2015-11-05 CA CA2964785A patent/CA2964785A1/en not_active Abandoned
- 2015-11-05 EP EP19152625.0A patent/EP3536707A1/en not_active Withdrawn
- 2015-11-05 JP JP2017543315A patent/JP2017535284A/ja not_active Withdrawn
- 2015-11-05 US US15/524,328 patent/US20170333480A1/en not_active Abandoned
- 2015-11-05 WO PCT/US2015/059293 patent/WO2016073755A2/en not_active Ceased
- 2015-11-05 KR KR1020177014630A patent/KR20170075785A/ko not_active Withdrawn
- 2015-11-05 AU AU2015343013A patent/AU2015343013B2/en not_active Ceased
- 2015-11-05 HK HK18103028.0A patent/HK1243441A1/zh unknown
- 2015-11-05 CN CN201580064711.8A patent/CN107207615A/zh active Pending
- 2015-11-05 EP EP15795304.3A patent/EP3215535A2/en not_active Withdrawn
-
2019
- 2019-11-08 JP JP2019203260A patent/JP2020022504A/ja active Pending
-
2020
- 2020-10-08 AU AU2020250247A patent/AU2020250247A1/en not_active Abandoned
-
2021
- 2021-07-09 US US17/371,924 patent/US20220072041A1/en not_active Abandoned
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