JP2018509148A5 - - Google Patents
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- JP2018509148A5 JP2018509148A5 JP2017547087A JP2017547087A JP2018509148A5 JP 2018509148 A5 JP2018509148 A5 JP 2018509148A5 JP 2017547087 A JP2017547087 A JP 2017547087A JP 2017547087 A JP2017547087 A JP 2017547087A JP 2018509148 A5 JP2018509148 A5 JP 2018509148A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- immune cells
- cell
- allogeneic
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201570138 | 2015-03-11 | ||
| DKPA201570138 | 2015-03-11 | ||
| PCT/EP2016/055332 WO2016142532A1 (en) | 2015-03-11 | 2016-03-11 | Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018509148A JP2018509148A (ja) | 2018-04-05 |
| JP2018509148A5 true JP2018509148A5 (enExample) | 2019-04-11 |
Family
ID=52682595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547087A Pending JP2018509148A (ja) | 2015-03-11 | 2016-03-11 | 患者における持続性および／または生着を増加させるために同種ｔ細胞を改変する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11186824B2 (enExample) |
| EP (1) | EP3268388A1 (enExample) |
| JP (1) | JP2018509148A (enExample) |
| KR (1) | KR20170137079A (enExample) |
| CN (1) | CN107683333A (enExample) |
| AU (1) | AU2016231061B2 (enExample) |
| BR (1) | BR112017018224A2 (enExample) |
| CA (1) | CA2978840A1 (enExample) |
| IL (1) | IL253879A0 (enExample) |
| MX (1) | MX2017011418A (enExample) |
| RU (1) | RU2017134441A (enExample) |
| WO (1) | WO2016142532A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015136001A1 (en) * | 2014-03-11 | 2015-09-17 | Cellectis | Method for generating t-cells compatible for allogenic transplantation |
| JP2018520688A (ja) | 2015-07-21 | 2018-08-02 | ザ チルドレンズ メディカル センター コーポレーション | Ｐｄ−ｌ１発現造血幹細胞およびその使用 |
| IL259576B (en) | 2015-12-04 | 2022-09-01 | Novartis Ag | grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy |
| IL265438B2 (en) * | 2016-09-23 | 2023-10-01 | Univ Southern California | Chimeric antigen receptors and compositions and methods of use thereof |
| WO2018115189A1 (en) | 2016-12-21 | 2018-06-28 | Cellectis | Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy |
| EP3568464A1 (en) * | 2017-01-13 | 2019-11-20 | The Regents of The University of California | Immunoengineered pluripotent cells |
| CA3054621A1 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| US20200399343A1 (en) * | 2017-04-19 | 2020-12-24 | Allogene Therapeutics, Inc. | Improved t cell compositions and methods |
| CN107177632B (zh) * | 2017-05-27 | 2020-02-07 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用 |
| US12296012B2 (en) | 2017-06-02 | 2025-05-13 | Pfizer Inc. | Chimeric antigen receptors targeting FLT3 |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| CN111511903B (zh) * | 2017-10-19 | 2024-10-11 | 塞勒克提斯公司 | 用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合 |
| CN109836497A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种靶向egfr的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| US20230158070A1 (en) | 2018-01-30 | 2023-05-25 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen |
| EP3757133A4 (en) * | 2018-02-11 | 2021-12-01 | Jiangsu Hengrui Medicine Co., Ltd. | ISOLATED ANTIGENIC CHEMICAL RECEPTOR, MODIFIED T LYMPHOCYTE INCLUDING IT AND ASSOCIATED USE |
| CN112368013B (zh) * | 2018-04-26 | 2025-05-16 | 贝勒医学院 | 用于选择性靶向活化的致病性t细胞和nk细胞的自体/同种异体免疫防御受体 |
| GB201813178D0 (en) * | 2018-08-13 | 2018-09-26 | Autolus Ltd | Cell |
| US12529041B2 (en) | 2018-09-07 | 2026-01-20 | Beam Therapeutics Inc. | Compositions and methods for delivering a nucleobase editing system |
| US12454694B2 (en) | 2018-09-07 | 2025-10-28 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| CN109055380B (zh) * | 2018-09-19 | 2021-08-27 | 深圳市菲鹏生物治疗股份有限公司 | 一种通用型car-t细胞的制备方法 |
| US20220016166A1 (en) * | 2018-09-21 | 2022-01-20 | Cafa Therapeutics Limited | T-cell expressing chimeric receptor |
| CN109293773B (zh) * | 2018-09-25 | 2020-09-04 | 上海邦耀生物科技有限公司 | 靶向cd38蛋白的抗体、嵌合抗原受体和药物 |
| KR20210125978A (ko) | 2018-11-01 | 2021-10-19 | 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 | T 세포 조작을 위한 조성물 및 방법 |
| CN113227141A (zh) * | 2018-11-07 | 2021-08-06 | 克里斯珀医疗股份公司 | 抗cd33免疫细胞癌症疗法 |
| KR20210118945A (ko) | 2019-02-15 | 2021-10-01 | 유니버시티 오브 써던 캘리포니아 | Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물 |
| CA3130698A1 (en) * | 2019-03-18 | 2020-09-24 | Steven John GRECO | Methods and clinical protocols and kits pertaining to making and using therapeutic compositions for cellular treatment |
| WO2020214606A1 (en) * | 2019-04-15 | 2020-10-22 | The Medical College Of Wisconsin, Inc. | Recombinant pd-l1 peptides and methods of use |
| AU2020274027A1 (en) | 2019-05-10 | 2021-11-11 | The Regents Of The University Of California | Modified pluripotent cells |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| JP7620548B2 (ja) * | 2019-06-26 | 2025-01-23 | 武田薬品工業株式会社 | トランスフェクション方法 |
| EP4003375A4 (en) * | 2019-07-31 | 2023-09-06 | Forty Seven, Inc. | DEPLETION DIETS FOR MODIFIED T CELL OR NK CELL THERAPY |
| AU2020401315B2 (en) | 2019-12-11 | 2023-11-09 | A2 Biotherapeutics, Inc. | LILRB1-based chimeric antigen receptor |
| KR102246067B1 (ko) * | 2020-05-13 | 2021-04-29 | (주)세렌라이프 | 효능이 증진된 줄기세포를 포함하는 세포 생착능 증진용 조성물 |
| CN115551998A (zh) * | 2020-05-26 | 2022-12-30 | 希里欧斯株式会社 | 低免疫原性细胞 |
| EP4097486A4 (en) | 2020-08-20 | 2023-09-06 | A2 Biotherapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM |
| EP4100028A4 (en) | 2020-08-20 | 2023-07-26 | A2 Biotherapeutics, Inc. | Compositions and methods for treating mesothelin positive cancers |
| WO2022040444A1 (en) | 2020-08-20 | 2022-02-24 | A2 Biotherapeutics, Inc. | Compositions and methods for treating egfr positive cancers |
| US20240000938A1 (en) * | 2020-11-24 | 2024-01-04 | A2 Biotherapeutics, Inc. | Adoptive cell therapy for treatment of cancer associated with loss of heterozygosity |
| CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
| EP4284918A1 (en) | 2021-01-29 | 2023-12-06 | Allogene Therapeutics, Inc. | Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products |
| US20240139322A1 (en) * | 2021-03-10 | 2024-05-02 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Compositions and methods to reduce therapeutic t cell toxicity |
| EP4547825A1 (en) | 2022-07-01 | 2025-05-07 | Novo Nordisk A/S | Enhancing neuronal differentiation of ventral midbrain neural progenitor cells |
| WO2025003393A1 (en) | 2023-06-30 | 2025-01-02 | Novo Nordisk A/S | Enhancing neuronal differentiation of neural progenitor cells |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5574205A (en) * | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU4328801A (en) | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| US20060222633A1 (en) | 2000-05-11 | 2006-10-05 | Yale University | Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host |
| US7094874B2 (en) * | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| EP1620537B1 (en) | 2003-03-14 | 2012-10-24 | Cellectis SA | Large volume ex vivo electroporation method |
| CA2563313C (en) | 2004-04-05 | 2014-06-03 | The Regents Of The University Of California | Modulation of nkg2d |
| US8986712B2 (en) | 2009-11-29 | 2015-03-24 | Yeda Research And Development Co., Ltd. | Peptides derived from HIV-1 gp41 transmembrane domain for t-immunomodulation |
| CA3253628A1 (en) * | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| CA3111953C (en) | 2011-04-05 | 2023-10-24 | Cellectis | Method for the generation of compact tale-nucleases and uses thereof |
| US9212224B2 (en) | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
| SG10201806573TA (en) | 2012-05-25 | 2018-09-27 | Cellectis | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
| US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| AU2013312838B2 (en) | 2012-09-04 | 2018-11-29 | Cellectis | Multi-chain chimeric antigen receptor and uses thereof |
| US9902973B2 (en) | 2013-04-11 | 2018-02-27 | Caribou Biosciences, Inc. | Methods of modifying a target nucleic acid with an argonaute |
| RU2725542C2 (ru) | 2013-05-13 | 2020-07-02 | Селлектис | Способы конструирования высокоактивных т-клеток для иммунотерапии |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| US10836998B2 (en) | 2014-02-14 | 2020-11-17 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| CA2943008C (en) | 2014-03-19 | 2021-03-30 | Cellectis | Cd123 specific chimeric antigen receptors for cancer immunotherapy |
-
2016
- 2016-03-11 KR KR1020177028154A patent/KR20170137079A/ko not_active Withdrawn
- 2016-03-11 CN CN201680014457.5A patent/CN107683333A/zh active Pending
- 2016-03-11 WO PCT/EP2016/055332 patent/WO2016142532A1/en not_active Ceased
- 2016-03-11 RU RU2017134441A patent/RU2017134441A/ru not_active Application Discontinuation
- 2016-03-11 AU AU2016231061A patent/AU2016231061B2/en active Active
- 2016-03-11 CA CA2978840A patent/CA2978840A1/en active Pending
- 2016-03-11 JP JP2017547087A patent/JP2018509148A/ja active Pending
- 2016-03-11 MX MX2017011418A patent/MX2017011418A/es unknown
- 2016-03-11 BR BR112017018224A patent/BR112017018224A2/pt not_active IP Right Cessation
- 2016-03-11 US US15/556,558 patent/US11186824B2/en active Active
- 2016-03-11 EP EP16710948.7A patent/EP3268388A1/en active Pending
-
2017
- 2017-08-07 IL IL253879A patent/IL253879A0/en unknown
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