KR20170137079A - 그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들 - Google Patents

그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들 Download PDF

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KR20170137079A
KR20170137079A KR1020177028154A KR20177028154A KR20170137079A KR 20170137079 A KR20170137079 A KR 20170137079A KR 1020177028154 A KR1020177028154 A KR 1020177028154A KR 20177028154 A KR20177028154 A KR 20177028154A KR 20170137079 A KR20170137079 A KR 20170137079A
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cells
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expression
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필리페 두차토
장-피에르 카바니올스
줄리안 발통
로렝 포이로
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셀렉티스
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KR1020177028154A 2015-03-11 2016-03-11 그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들 Withdrawn KR20170137079A (ko)

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Application Number Priority Date Filing Date Title
DKPA201570138 2015-03-11
DKPA201570138 2015-03-11
PCT/EP2016/055332 WO2016142532A1 (en) 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients

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KR20170137079A true KR20170137079A (ko) 2017-12-12

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KR1020177028154A Withdrawn KR20170137079A (ko) 2015-03-11 2016-03-11 그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들

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US (1) US11186824B2 (enExample)
EP (1) EP3268388A1 (enExample)
JP (1) JP2018509148A (enExample)
KR (1) KR20170137079A (enExample)
CN (1) CN107683333A (enExample)
AU (1) AU2016231061B2 (enExample)
BR (1) BR112017018224A2 (enExample)
CA (1) CA2978840A1 (enExample)
IL (1) IL253879A0 (enExample)
MX (1) MX2017011418A (enExample)
RU (1) RU2017134441A (enExample)
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WO2015136001A1 (en) * 2014-03-11 2015-09-17 Cellectis Method for generating t-cells compatible for allogenic transplantation
JP2018520688A (ja) 2015-07-21 2018-08-02 ザ チルドレンズ メディカル センター コーポレーション Ｐｄ−ｌ１発現造血幹細胞およびその使用
IL259576B (en) 2015-12-04 2022-09-01 Novartis Ag grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy
IL265438B2 (en) * 2016-09-23 2023-10-01 Univ Southern California Chimeric antigen receptors and compositions and methods of use thereof
WO2018115189A1 (en) 2016-12-21 2018-06-28 Cellectis Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
EP3568464A1 (en) * 2017-01-13 2019-11-20 The Regents of The University of California Immunoengineered pluripotent cells
CA3054621A1 (en) 2017-03-22 2018-09-27 Novartis Ag Compositions and methods for immunooncology
US20200399343A1 (en) * 2017-04-19 2020-12-24 Allogene Therapeutics, Inc. Improved t cell compositions and methods
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
US12296012B2 (en) 2017-06-02 2025-05-13 Pfizer Inc. Chimeric antigen receptors targeting FLT3
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
CN111511903B (zh) * 2017-10-19 2024-10-11 塞勒克提斯公司 用于改善的免疫细胞疗法的nk抑制剂基因的靶向基因整合
CN109836497A (zh) * 2017-11-25 2019-06-04 深圳宾德生物技术有限公司 一种靶向egfr的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
US20230158070A1 (en) 2018-01-30 2023-05-25 Cellectis Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen
EP3757133A4 (en) * 2018-02-11 2021-12-01 Jiangsu Hengrui Medicine Co., Ltd. ISOLATED ANTIGENIC CHEMICAL RECEPTOR, MODIFIED T LYMPHOCYTE INCLUDING IT AND ASSOCIATED USE
CN112368013B (zh) * 2018-04-26 2025-05-16 贝勒医学院 用于选择性靶向活化的致病性t细胞和nk细胞的自体/同种异体免疫防御受体
GB201813178D0 (en) * 2018-08-13 2018-09-26 Autolus Ltd Cell
US12529041B2 (en) 2018-09-07 2026-01-20 Beam Therapeutics Inc. Compositions and methods for delivering a nucleobase editing system
US12454694B2 (en) 2018-09-07 2025-10-28 Beam Therapeutics Inc. Compositions and methods for improving base editing
CN109055380B (zh) * 2018-09-19 2021-08-27 深圳市菲鹏生物治疗股份有限公司 一种通用型car-t细胞的制备方法
US20220016166A1 (en) * 2018-09-21 2022-01-20 Cafa Therapeutics Limited T-cell expressing chimeric receptor
CN109293773B (zh) * 2018-09-25 2020-09-04 上海邦耀生物科技有限公司 靶向cd38蛋白的抗体、嵌合抗原受体和药物
KR20210125978A (ko) 2018-11-01 2021-10-19 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 T 세포 조작을 위한 조성물 및 방법
CN113227141A (zh) * 2018-11-07 2021-08-06 克里斯珀医疗股份公司 抗cd33免疫细胞癌症疗法
KR20210118945A (ko) 2019-02-15 2021-10-01 유니버시티 오브 써던 캘리포니아 Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물
CA3130698A1 (en) * 2019-03-18 2020-09-24 Steven John GRECO Methods and clinical protocols and kits pertaining to making and using therapeutic compositions for cellular treatment
WO2020214606A1 (en) * 2019-04-15 2020-10-22 The Medical College Of Wisconsin, Inc. Recombinant pd-l1 peptides and methods of use
AU2020274027A1 (en) 2019-05-10 2021-11-11 The Regents Of The University Of California Modified pluripotent cells
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
JP7620548B2 (ja) * 2019-06-26 2025-01-23 武田薬品工業株式会社 トランスフェクション方法
EP4003375A4 (en) * 2019-07-31 2023-09-06 Forty Seven, Inc. DEPLETION DIETS FOR MODIFIED T CELL OR NK CELL THERAPY
AU2020401315B2 (en) 2019-12-11 2023-11-09 A2 Biotherapeutics, Inc. LILRB1-based chimeric antigen receptor
KR102246067B1 (ko) * 2020-05-13 2021-04-29 (주)세렌라이프 효능이 증진된 줄기세포를 포함하는 세포 생착능 증진용 조성물
CN115551998A (zh) * 2020-05-26 2022-12-30 希里欧斯株式会社 低免疫原性细胞
EP4097486A4 (en) 2020-08-20 2023-09-06 A2 Biotherapeutics, Inc. COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM
EP4100028A4 (en) 2020-08-20 2023-07-26 A2 Biotherapeutics, Inc. Compositions and methods for treating mesothelin positive cancers
WO2022040444A1 (en) 2020-08-20 2022-02-24 A2 Biotherapeutics, Inc. Compositions and methods for treating egfr positive cancers
US20240000938A1 (en) * 2020-11-24 2024-01-04 A2 Biotherapeutics, Inc. Adoptive cell therapy for treatment of cancer associated with loss of heterozygosity
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
EP4284918A1 (en) 2021-01-29 2023-12-06 Allogene Therapeutics, Inc. Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products
US20240139322A1 (en) * 2021-03-10 2024-05-02 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods to reduce therapeutic t cell toxicity
EP4547825A1 (en) 2022-07-01 2025-05-07 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
WO2025003393A1 (en) 2023-06-30 2025-01-02 Novo Nordisk A/S Enhancing neuronal differentiation of neural progenitor cells

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US5574205A (en) * 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
AU4328801A (en) 2000-02-24 2001-09-03 Xcyte Therapies Inc Simultaneous stimulation and concentration of cells
US20060222633A1 (en) 2000-05-11 2006-10-05 Yale University Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
US7094874B2 (en) * 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
EP1620537B1 (en) 2003-03-14 2012-10-24 Cellectis SA Large volume ex vivo electroporation method
CA2563313C (en) 2004-04-05 2014-06-03 The Regents Of The University Of California Modulation of nkg2d
US8986712B2 (en) 2009-11-29 2015-03-24 Yeda Research And Development Co., Ltd. Peptides derived from HIV-1 gp41 transmembrane domain for t-immunomodulation
CA3253628A1 (en) * 2010-03-05 2025-11-29 The Johns Hopkins University Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
CA3111953C (en) 2011-04-05 2023-10-24 Cellectis Method for the generation of compact tale-nucleases and uses thereof
US9212224B2 (en) 2012-05-15 2015-12-15 Bristol-Myers Squibb Company Antibodies that bind PD-L1 and uses thereof
SG10201806573TA (en) 2012-05-25 2018-09-27 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
AU2013312838B2 (en) 2012-09-04 2018-11-29 Cellectis Multi-chain chimeric antigen receptor and uses thereof
US9902973B2 (en) 2013-04-11 2018-02-27 Caribou Biosciences, Inc. Methods of modifying a target nucleic acid with an argonaute
RU2725542C2 (ru) 2013-05-13 2020-07-02 Селлектис Способы конструирования высокоактивных т-клеток для иммунотерапии
US9890393B2 (en) 2013-05-29 2018-02-13 Cellectis Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
US10836998B2 (en) 2014-02-14 2020-11-17 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
CA2943008C (en) 2014-03-19 2021-03-30 Cellectis Cd123 specific chimeric antigen receptors for cancer immunotherapy

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