AU2016231061B2 - Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients - Google Patents

Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients Download PDF

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AU2016231061B2
AU2016231061B2 AU2016231061A AU2016231061A AU2016231061B2 AU 2016231061 B2 AU2016231061 B2 AU 2016231061B2 AU 2016231061 A AU2016231061 A AU 2016231061A AU 2016231061 A AU2016231061 A AU 2016231061A AU 2016231061 B2 AU2016231061 B2 AU 2016231061B2
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cell
allogeneic
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expression
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AU2016231061A1 (en
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Jean-Pierre Cabaniols
Philippe Duchateau
Laurent Poirot
Julien Valton
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Cellectis SA
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AU2016231061A 2015-03-11 2016-03-11 Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients Active AU2016231061B2 (en)

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PCT/EP2016/055332 WO2016142532A1 (en) 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2782125T3 (es) * 2014-03-11 2020-09-10 Cellectis Método para generar linfocitos T compatibles para trasplante alogénico
CA2993201A1 (en) 2015-07-21 2017-01-26 The Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
CA3006432A1 (en) 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
JP2020501512A (ja) * 2016-09-23 2020-01-23 ユニバーシティ オブ サザン カリフォルニア キメラ抗原受容体およびその組成物ならびにそれらの使用の方法
WO2018115189A1 (en) 2016-12-21 2018-06-28 Cellectis Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
JP2020505025A (ja) * 2017-01-13 2020-02-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 免疫工学的な改変をした多能性細胞
SG11201907434RA (en) 2017-03-22 2019-10-30 Novartis Ag Compositions and methods for immunooncology
EP3612275A1 (en) * 2017-04-19 2020-02-26 Allogene Therapeutics, Inc. Improved t cell compositions and methods
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
EP3630837A1 (en) 2017-06-02 2020-04-08 Pfizer Inc Chimeric antigen receptors targeting flt3
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
MX2020004444A (es) * 2017-10-19 2020-07-22 Cellectis Integracion genica direccionada de genes de inhibidores de nk para terapia con celulas inmunes mejorada.
CN109836497A (zh) * 2017-11-25 2019-06-04 深圳宾德生物技术有限公司 一种靶向egfr的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
EP3694546A1 (en) 2018-01-30 2020-08-19 Cellectis Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen
US20230183313A1 (en) * 2018-02-11 2023-06-15 Jiangsu Hengrui Medicine Co., Ltd. Isolated chimeric antigen receptor, modified t cell comprising same and use thereof
BR112020021685A2 (pt) * 2018-04-26 2021-01-26 Baylor College Of Medicine receptores de defesa auto/aloimune para o direcionamento seletivo de células t e células nk patogênicas ativadas
GB201813178D0 (en) * 2018-08-13 2018-09-26 Autolus Ltd Cell
US12529041B2 (en) 2018-09-07 2026-01-20 Beam Therapeutics Inc. Compositions and methods for delivering a nucleobase editing system
WO2020051562A2 (en) 2018-09-07 2020-03-12 Beam Therapeutics Inc. Compositions and methods for improving base editing
CN109055380B (zh) * 2018-09-19 2021-08-27 深圳市菲鹏生物治疗股份有限公司 一种通用型car-t细胞的制备方法
US20220017926A1 (en) * 2018-09-21 2022-01-20 Cafa Therapeutics Limited Method for gene editing of cell on the basis of crispr/cas system
CN109293773B (zh) * 2018-09-25 2020-09-04 上海邦耀生物科技有限公司 靶向cd38蛋白的抗体、嵌合抗原受体和药物
EP4578507A3 (en) * 2018-11-01 2025-11-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
EP3877414A1 (en) * 2018-11-07 2021-09-15 CRISPR Therapeutics AG Anti-cd33 immune cell cancer therapy
CA3129501A1 (en) 2019-02-15 2020-08-20 University Of Southern California Lym-1 and lym-2 antibody compositions and improved car constructs
CA3130698A1 (en) * 2019-03-18 2020-09-24 Steven John GRECO Methods and clinical protocols and kits pertaining to making and using therapeutic compositions for cellular treatment
WO2020214606A1 (en) * 2019-04-15 2020-10-22 The Medical College Of Wisconsin, Inc. Recombinant pd-l1 peptides and methods of use
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
EP3966316A4 (en) 2019-05-10 2023-01-25 The Regents of The University of California MODIFIED PLURIPOTENT CELLS
JP7620548B2 (ja) * 2019-06-26 2025-01-23 武田薬品工業株式会社 トランスフェクション方法
US20220288118A1 (en) * 2019-07-31 2022-09-15 Forty Seven, Inc. Depletion regimes for engineered t-cell or nk-cell therapy
IL293716A (en) 2019-12-11 2022-08-01 A2 Biotherapeutics Inc Lilrb1-based chimeric antigen receptor
KR102246067B1 (ko) * 2020-05-13 2021-04-29 (주)세렌라이프 효능이 증진된 줄기세포를 포함하는 세포 생착능 증진용 조성물
CN115551998A (zh) * 2020-05-26 2022-12-30 希里欧斯株式会社 低免疫原性细胞
JP7634653B2 (ja) 2020-08-20 2025-02-21 エー2 バイオセラピューティクス, インコーポレイテッド メソテリン陽性がんを治療するための組成物及び方法
CA3188867A1 (en) 2020-08-20 2022-02-24 Xueyin Wang Compositions and methods for treating ceacam positive cancers
PL4058474T3 (pl) 2020-08-20 2024-09-23 A2 Biotherapeutics, Inc. Kompozycje i sposoby leczenia nowotworów egfr-dodatnich
US20240000938A1 (en) * 2020-11-24 2024-01-04 A2 Biotherapeutics, Inc. Adoptive cell therapy for treatment of cancer associated with loss of heterozygosity
JP2024500847A (ja) 2020-12-18 2024-01-10 センチュリー セラピューティクス,インコーポレイテッド 適合可能な受容体特異性を有するキメラ抗原受容体システム
JP2024510184A (ja) * 2021-03-10 2024-03-06 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 治療用t細胞毒性を減少させるための組成物および方法
EP4547825A1 (en) 2022-07-01 2025-05-07 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
CN121420058A (zh) 2023-06-30 2026-01-27 诺和诺德股份有限公司 增强神经祖细胞的神经元分化

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017911A1 (en) * 1993-12-30 1995-07-06 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
ES2302726T3 (es) 2000-02-24 2008-08-01 Invitrogen Corporation Estimulacion y concentracion simultanea de celulas.
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20060222633A1 (en) 2000-05-11 2006-10-05 Yale University Prevention, decrease, and/or treatment of immunoreactivity by depleting and/or inactivating antigen presenting cells in the host
US7094874B2 (en) * 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
CN1826408B (zh) 2003-03-14 2011-01-26 塞托·帕尔斯科技公司 大容量离体电穿孔法
WO2005097160A2 (en) * 2004-04-05 2005-10-20 The Regents Of The University Of California Modulation of nkg2d
WO2011064779A2 (en) 2009-11-29 2011-06-03 Yeda Research And Development Co. Ltd. PEPTIDES DERIVED FROM HIV-1 gp41 TRANSMEMBRANE DOMAIN AND METHODS OF USE THEREOF
DK2542590T4 (da) * 2010-03-05 2020-07-13 Univ Johns Hopkins Sammensætninger og fremgangsmåde til målrettede immunomodulatoriske antistof-fer og fusionproteiner
SG10201602651YA (en) 2011-04-05 2016-05-30 Cellectis Method for the generation of compact tale-nucleases and uses thereof
CA3213528A1 (en) 2012-05-15 2013-11-21 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
KR102247979B1 (ko) 2012-05-25 2021-05-04 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법
US20150017136A1 (en) 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
CN104769103B (zh) 2012-09-04 2018-06-08 塞勒克提斯公司 多链嵌合抗原受体和其用途
US9902973B2 (en) 2013-04-11 2018-02-27 Caribou Biosciences, Inc. Methods of modifying a target nucleic acid with an argonaute
AU2014266833B2 (en) 2013-05-13 2020-07-02 Cellectis Methods for engineering highly active T cell for immunotherapy
EP3004337B1 (en) * 2013-05-29 2017-08-02 Cellectis Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
TR201819571T4 (tr) 2014-02-14 2019-01-21 Cellectis Hem immün hücrelerde hem de patolojik hücrelerde bulunan antijenleri hedef almak amacıyla değiştirilmiş immünoterapiye yönelik hücreler.
TR201910814T4 (tr) 2014-03-19 2019-08-21 Cellectis Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017911A1 (en) * 1993-12-30 1995-07-06 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts

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