CA2978840A1 - Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients - Google Patents

Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients Download PDF

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Publication number
CA2978840A1
CA2978840A1 CA2978840A CA2978840A CA2978840A1 CA 2978840 A1 CA2978840 A1 CA 2978840A1 CA 2978840 A CA2978840 A CA 2978840A CA 2978840 A CA2978840 A CA 2978840A CA 2978840 A1 CA2978840 A1 CA 2978840A1
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Prior art keywords
cells
cell
expression
seq
immune cells
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CA2978840A
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English (en)
French (fr)
Inventor
Philippe Duchateau
Jean-Pierre Cabaniols
Julien Valton
Laurent Poirot
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Cellectis SA
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Cellectis SA
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Publication of CA2978840A1 publication Critical patent/CA2978840A1/en
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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CA2978840A 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients Pending CA2978840A1 (en)

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Application Number Priority Date Filing Date Title
DKPA201570138 2015-03-11
DKPA201570138 2015-03-11
PCT/EP2016/055332 WO2016142532A1 (en) 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients

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CA2978840A1 true CA2978840A1 (en) 2016-09-15

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US (1) US11186824B2 (enExample)
EP (1) EP3268388A1 (enExample)
JP (1) JP2018509148A (enExample)
KR (1) KR20170137079A (enExample)
CN (1) CN107683333A (enExample)
AU (1) AU2016231061B2 (enExample)
BR (1) BR112017018224A2 (enExample)
CA (1) CA2978840A1 (enExample)
IL (1) IL253879A0 (enExample)
MX (1) MX2017011418A (enExample)
RU (1) RU2017134441A (enExample)
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RU2752933C2 (ru) 2014-03-11 2021-08-11 Селлектис Способ создания т-клеток, пригодных для аллогенной трансплантации
BR112018001232A2 (pt) 2015-07-21 2018-09-25 The Children's Medical Center Corporation pd-l1 que expressa células-tronco hematopoéticas e usos
WO2017093969A1 (en) 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
EP3515493A4 (en) * 2016-09-23 2020-08-19 University of Southern California CHEMERICAL ANTIGEN RECEPTORS, COORESPONDENT COMPOSITIONS AND METHODS OF USE
WO2018115189A1 (en) 2016-12-21 2018-06-28 Cellectis Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
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