BR112017018224A2 - métodos para manipulação de célula t alogênica para aumentar sua persistência e/ou implante em pacientes - Google Patents

métodos para manipulação de célula t alogênica para aumentar sua persistência e/ou implante em pacientes

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Publication number
BR112017018224A2
BR112017018224A2 BR112017018224A BR112017018224A BR112017018224A2 BR 112017018224 A2 BR112017018224 A2 BR 112017018224A2 BR 112017018224 A BR112017018224 A BR 112017018224A BR 112017018224 A BR112017018224 A BR 112017018224A BR 112017018224 A2 BR112017018224 A2 BR 112017018224A2
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BR
Brazil
Prior art keywords
implantation
methods
allogeneic
patients
cell manipulation
Prior art date
Application number
BR112017018224A
Other languages
English (en)
Portuguese (pt)
Inventor
Cabaniols Jean-Pierre
Valton Julien
Poirot Laurent
Duchateau Philippe
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of BR112017018224A2 publication Critical patent/BR112017018224A2/pt

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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BR112017018224A 2015-03-11 2016-03-11 métodos para manipulação de célula t alogênica para aumentar sua persistência e/ou implante em pacientes BR112017018224A2 (pt)

Applications Claiming Priority (2)

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DKPA201570138 2015-03-11
PCT/EP2016/055332 WO2016142532A1 (en) 2015-03-11 2016-03-11 Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients

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BR112017018224A2 true BR112017018224A2 (pt) 2018-04-17

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US (1) US11186824B2 (enExample)
EP (1) EP3268388A1 (enExample)
JP (1) JP2018509148A (enExample)
KR (1) KR20170137079A (enExample)
CN (1) CN107683333A (enExample)
AU (1) AU2016231061B2 (enExample)
BR (1) BR112017018224A2 (enExample)
CA (1) CA2978840A1 (enExample)
IL (1) IL253879A0 (enExample)
MX (1) MX2017011418A (enExample)
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EP3693384B1 (en) * 2014-03-11 2024-01-24 Cellectis Method for generating t-cells compatible for allogenic transplantation
CA2993201A1 (en) 2015-07-21 2017-01-26 The Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
HK1257295A1 (zh) 2015-12-04 2019-10-18 Novartis Ag 用於免疫肿瘤学的组合物和方法
JP2020501512A (ja) * 2016-09-23 2020-01-23 ユニバーシティ オブ サザン カリフォルニア キメラ抗原受容体およびその組成物ならびにそれらの使用の方法
WO2018115189A1 (en) 2016-12-21 2018-06-28 Cellectis Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
EP3568464A1 (en) * 2017-01-13 2019-11-20 The Regents of The University of California Immunoengineered pluripotent cells
EP3601561A2 (en) 2017-03-22 2020-02-05 Novartis AG Compositions and methods for immunooncology
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