BR112017008710A8 - Composições e métodos para estimular a eficácia de imunoterapia celular adotiva - Google Patents
Composições e métodos para estimular a eficácia de imunoterapia celular adotivaInfo
- Publication number
- BR112017008710A8 BR112017008710A8 BR112017008710A BR112017008710A BR112017008710A8 BR 112017008710 A8 BR112017008710 A8 BR 112017008710A8 BR 112017008710 A BR112017008710 A BR 112017008710A BR 112017008710 A BR112017008710 A BR 112017008710A BR 112017008710 A8 BR112017008710 A8 BR 112017008710A8
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- effectiveness
- methods
- compositions
- stimulate
- Prior art date
Links
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 102000025171 antigen binding proteins Human genes 0.000 abstract 2
- 108091000831 antigen binding proteins Proteins 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
A presente revelação fornece composições e métodos para estimular, aumentar ou aprimorar a eficácia da imunoterapia celular adotiva com o uso de células T modificadas que expressam uma proteína de ligação de antígeno em conjunto com células modificadas (tais como células progenitoras hematopoiéticas, células de sistema imunológico humanas modificadas ou uma combinação das mesmas) que expressam o antígeno especificamente ligado pela proteína de ligação de antígeno das células T modificadas.
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US201462069168P | 2014-10-27 | 2014-10-27 | |
PCT/US2015/057652 WO2016069647A1 (en) | 2014-10-27 | 2015-10-27 | Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy |
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BR112017008710A8 true BR112017008710A8 (pt) | 2023-04-25 |
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US11458167B2 (en) | 2015-08-07 | 2022-10-04 | Seattle Children's Hospital | Bispecific CAR T-cells for solid tumor targeting |
EA201891066A1 (ru) | 2015-10-30 | 2018-10-31 | ЭнБиИ-ТЕРАПЬЮТИКС АГ | Антитела к ror1 |
WO2017127664A1 (en) | 2016-01-20 | 2017-07-27 | The Scripps Research Institute | Ror1 antibody compositions and related methods |
US10968275B2 (en) | 2016-02-02 | 2021-04-06 | Fred Hutchinson Cancer Research Center | Anti-ROR1 antibodies and uses thereof |
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MA45025A (fr) * | 2016-05-20 | 2019-03-27 | Lilly Co Eli | Traitement d'association utilisant des inhibiteurs de notch et de pd-1 ou pd-l1 |
CN106199005B (zh) * | 2016-07-26 | 2019-02-01 | 浙江大学 | 采用cd137表达量检测淋巴细胞抗大肠癌活性的方法 |
BR112019011065A2 (pt) | 2016-12-03 | 2019-10-01 | Juno Therapeutics Inc | métodos para determinação da dosagem de células t car |
BR112019011207A2 (pt) | 2016-12-05 | 2019-10-08 | Juno Therapeutics Inc | produção de células modificadas para terapia celular adotiva |
CN110392736A (zh) * | 2017-01-18 | 2019-10-29 | 耶达研究及发展有限公司 | 遗传修饰的反抑细胞及其在免疫治疗中的用途 |
CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
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CA3070855A1 (en) * | 2017-08-11 | 2019-02-14 | Fred Hutchinson Cancer Research Center | Braf-specific tcrs and uses thereof |
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US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
EP3688143A4 (en) * | 2017-09-26 | 2021-09-22 | Longwood University | PD1 SPECIFIC CHIMERIC ANTIGEN RECEPTOR AS IMMUNOTHERAPY |
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JP2021508317A (ja) | 2017-12-01 | 2021-03-04 | ジュノー セラピューティクス インコーポレイテッド | 遺伝子操作された細胞の投与および調節のための方法 |
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