BR112017014258A2 - anticorpos anti-cd47 e usos dos mesmos - Google Patents

anticorpos anti-cd47 e usos dos mesmos

Info

Publication number
BR112017014258A2
BR112017014258A2 BR112017014258A BR112017014258A BR112017014258A2 BR 112017014258 A2 BR112017014258 A2 BR 112017014258A2 BR 112017014258 A BR112017014258 A BR 112017014258A BR 112017014258 A BR112017014258 A BR 112017014258A BR 112017014258 A2 BR112017014258 A2 BR 112017014258A2
Authority
BR
Brazil
Prior art keywords
methods
antibodies
compositions
human
producing
Prior art date
Application number
BR112017014258A
Other languages
English (en)
Inventor
Sato Aaron
Yang Junhao
stafford Ryan
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BR112017014258A2 publication Critical patent/BR112017014258A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

composições, métodos e usos envolvendo anticorpos que se ligam especificamente ao cd47 humano são fornecidos aqui. também são fornecidos usos e métodos, tais como métodos terapêuticos, métodos de diagnóstico e métodos para produzir tais anticorpos.
BR112017014258A 2014-12-30 2015-12-28 anticorpos anti-cd47 e usos dos mesmos BR112017014258A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098291P 2014-12-30 2014-12-30
PCT/US2015/067642 WO2016109415A1 (en) 2014-12-30 2015-12-28 Anti-cd47 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112017014258A2 true BR112017014258A2 (pt) 2018-03-06

Family

ID=56284963

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017014258A BR112017014258A2 (pt) 2014-12-30 2015-12-28 anticorpos anti-cd47 e usos dos mesmos

Country Status (17)

Country Link
US (2) US10870699B2 (pt)
EP (1) EP3240569A4 (pt)
JP (2) JP6850255B2 (pt)
KR (1) KR102489471B1 (pt)
CN (1) CN107530421B (pt)
AU (1) AU2015374301B2 (pt)
BR (1) BR112017014258A2 (pt)
CA (1) CA2972604C (pt)
CL (1) CL2017001736A1 (pt)
CO (1) CO2017007673A2 (pt)
EA (1) EA037654B1 (pt)
EC (1) ECSP17041865A (pt)
HK (1) HK1245154A1 (pt)
MX (1) MX2017008819A (pt)
SG (2) SG11201705310TA (pt)
WO (1) WO2016109415A1 (pt)
ZA (1) ZA201704467B (pt)

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Also Published As

Publication number Publication date
HK1245154A1 (zh) 2018-08-24
SG11201705310TA (en) 2017-07-28
EA201791485A1 (ru) 2018-02-28
JP6850255B2 (ja) 2021-03-31
US10870699B2 (en) 2020-12-22
JP2021048858A (ja) 2021-04-01
US11787860B2 (en) 2023-10-17
ZA201704467B (en) 2019-09-25
ECSP17041865A (es) 2017-08-31
CL2017001736A1 (es) 2018-03-16
SG10202007176TA (en) 2020-08-28
EA037654B1 (ru) 2021-04-27
WO2016109415A1 (en) 2016-07-07
CN107530421B (zh) 2021-07-20
EP3240569A4 (en) 2018-05-30
US20210054070A1 (en) 2021-02-25
JP2018506964A (ja) 2018-03-15
KR20170100652A (ko) 2017-09-04
AU2015374301B2 (en) 2021-02-11
AU2015374301A1 (en) 2017-07-20
MX2017008819A (es) 2018-03-14
CN107530421A (zh) 2018-01-02
EP3240569A1 (en) 2017-11-08
US20170369572A1 (en) 2017-12-28
CO2017007673A2 (es) 2018-01-05
CA2972604A1 (en) 2016-07-07
CA2972604C (en) 2023-07-04
KR102489471B1 (ko) 2023-01-18

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