CL2017001736A1 - Anticuerpos anti-cd47 y uso de los mismos. - Google Patents
Anticuerpos anti-cd47 y uso de los mismos.Info
- Publication number
- CL2017001736A1 CL2017001736A1 CL2017001736A CL2017001736A CL2017001736A1 CL 2017001736 A1 CL2017001736 A1 CL 2017001736A1 CL 2017001736 A CL2017001736 A CL 2017001736A CL 2017001736 A CL2017001736 A CL 2017001736A CL 2017001736 A1 CL2017001736 A1 CL 2017001736A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- antibodies
- prepare
- compositions
- diagnostic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
<p>SE PROPORCIONAN AQUÍ COMPOSICIONES, MÉTODOS Y USOS QUE IMPLICAN ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE A CD47 HUMANO. TAMBIÉN SE PROPORCIONAN USOS Y MÉTODOS, TALES COMO MÉTODOS TERAPÉUTICOS, MÉTODOS DE DIAGNÓSTICO Y MÉTODOS PARA PREPARAR DICHOS ANTICUERPOS.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462098291P | 2014-12-30 | 2014-12-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017001736A1 true CL2017001736A1 (es) | 2018-03-16 |
Family
ID=56284963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017001736A CL2017001736A1 (es) | 2014-12-30 | 2017-06-29 | Anticuerpos anti-cd47 y uso de los mismos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US10870699B2 (es) |
EP (1) | EP3240569A4 (es) |
JP (2) | JP6850255B2 (es) |
KR (1) | KR102489471B1 (es) |
CN (1) | CN107530421B (es) |
AU (1) | AU2015374301B2 (es) |
BR (1) | BR112017014258A2 (es) |
CA (1) | CA2972604C (es) |
CL (1) | CL2017001736A1 (es) |
CO (1) | CO2017007673A2 (es) |
EA (1) | EA037654B1 (es) |
EC (1) | ECSP17041865A (es) |
HK (1) | HK1245154A1 (es) |
MX (1) | MX2017008819A (es) |
SG (2) | SG11201705310TA (es) |
WO (1) | WO2016109415A1 (es) |
ZA (1) | ZA201704467B (es) |
Families Citing this family (62)
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SG11201705310TA (en) | 2014-12-30 | 2017-07-28 | Celgene Corp | Anti-cd47 antibodies and uses thereof |
CN107636014B (zh) * | 2015-05-04 | 2021-12-07 | 皮里斯制药有限公司 | 抗癌融合多肽 |
TW201811824A (zh) * | 2016-07-06 | 2018-04-01 | 美商西建公司 | 具有低免疫原性之抗體及其用途 |
IL265605B1 (en) | 2016-09-29 | 2024-02-01 | Beijing Hanmi Pharmaceutical Co Ltd | Heterodimeric immunoglobulin structures, a pharmaceutical preparation containing them, their use and methods for their preparation |
BR112019008010A2 (pt) | 2016-10-20 | 2019-07-09 | I Mab | anticorpo monoclonal isolado ou fragmento imunologicamente ativo do mesmo, anticorpo monoclonal biespecífico isolado, composição farmacêutica, método para tratamento de uma doença em um sujeito humano em necessidade do mesmo, proteína de fusão, epítopo imunodominante codificado pelo gene cd47, e, molécula biológica |
US11779631B2 (en) | 2016-11-03 | 2023-10-10 | Pfizer Inc. | CD47 blockade therapy by HDAC inhibitors |
EP3538557A4 (en) * | 2016-11-08 | 2020-11-18 | Ablexis, LLC | ANTI-CD47 ANTIBODIES |
US11319378B2 (en) | 2016-11-18 | 2022-05-03 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-PD-1/anti-HER2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same |
EP3574009A4 (en) * | 2017-01-26 | 2020-11-25 | Zlip Holding Limited | CD47 ANTIGEN BINDING UNIT AND ITS USES |
WO2018152033A1 (en) * | 2017-02-14 | 2018-08-23 | Promab Biotechnologies, Inc. | Cd47-car-t cells |
MX2019011624A (es) | 2017-03-27 | 2019-12-05 | Celgene Corp | Metodos y composiciones para la reduccion de la inmunogenicidad. |
EP3610022A1 (en) | 2017-04-14 | 2020-02-19 | Tollnine, Inc. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
US11401329B2 (en) * | 2017-08-02 | 2022-08-02 | Phanes Therapeutics, Inc. | Anti-CD47 antibodies and uses thereof |
SG11202001425TA (en) * | 2017-08-18 | 2020-03-30 | Ultrahuman Four Ltd | Binding agents |
CA3044097A1 (en) * | 2017-11-10 | 2019-05-16 | I-Mab | Fusion proteins containing cd47 antibodies and cytokines |
MX2020005463A (es) | 2017-12-01 | 2020-09-07 | Seattle Genetics Inc | Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer. |
SG11202005216XA (en) * | 2017-12-04 | 2020-07-29 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-l1/anti-cd47 bispecific antibody with structure like natural antibody and in form of heterodimer and preparation thereof |
AU2019212674A1 (en) * | 2018-01-24 | 2020-09-03 | Nanjing Legend Biotech Co., Ltd. | Anti-CD47 antibodies that do not cause significant red blood cell agglutination |
WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
GB201804860D0 (en) * | 2018-03-27 | 2018-05-09 | Ultrahuman Two Ltd | CD47 Binding agents |
CN110577597B (zh) * | 2018-06-11 | 2021-10-22 | 康诺亚生物医药科技(成都)有限公司 | 一种阻断CD47和SIRPα相互作用的抗体 |
CN112566662A (zh) | 2018-06-15 | 2021-03-26 | 阿库鲁斯生物科学公司 | 针对cd47的阻断抗体及其使用方法 |
WO2020009725A1 (en) * | 2018-07-05 | 2020-01-09 | Trican Biotechnology Co., Ltd | Human anti-cd47 antibodies and uses thereof |
CN110872348B (zh) * | 2018-09-03 | 2021-09-03 | 长春金赛药业有限责任公司 | 人源化抗cd47单克隆抗体及其应用 |
JP2022500357A (ja) * | 2018-10-31 | 2022-01-04 | アイ−マブ バイオファーマ ユーエス リミテッド | 新規cd47抗体およびその使用方法 |
JP2022523543A (ja) * | 2019-03-06 | 2022-04-25 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 二機能性融合タンパク質及びその医薬的使用 |
TW202104260A (zh) | 2019-04-05 | 2021-02-01 | 美商西建公司 | 腫瘤選擇性結合cd47之抗體之工程 |
US20200400662A1 (en) | 2019-06-07 | 2020-12-24 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
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KR20220085796A (ko) | 2019-10-18 | 2022-06-22 | 포티 세븐, 인코포레이티드 | 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료 |
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US20140140989A1 (en) | 2012-02-06 | 2014-05-22 | Inhibrx Llc | Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof |
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2015
- 2015-12-28 SG SG11201705310TA patent/SG11201705310TA/en unknown
- 2015-12-28 JP JP2017535814A patent/JP6850255B2/ja active Active
- 2015-12-28 CA CA2972604A patent/CA2972604C/en active Active
- 2015-12-28 CN CN201580077136.5A patent/CN107530421B/zh active Active
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- 2015-12-28 WO PCT/US2015/067642 patent/WO2016109415A1/en active Application Filing
- 2015-12-28 EA EA201791485A patent/EA037654B1/ru unknown
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Publication number | Publication date |
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ZA201704467B (en) | 2019-09-25 |
EA201791485A1 (ru) | 2018-02-28 |
US11787860B2 (en) | 2023-10-17 |
US10870699B2 (en) | 2020-12-22 |
KR20170100652A (ko) | 2017-09-04 |
CO2017007673A2 (es) | 2018-01-05 |
US20210054070A1 (en) | 2021-02-25 |
CN107530421B (zh) | 2021-07-20 |
JP6850255B2 (ja) | 2021-03-31 |
AU2015374301A1 (en) | 2017-07-20 |
MX2017008819A (es) | 2018-03-14 |
JP2021048858A (ja) | 2021-04-01 |
KR102489471B1 (ko) | 2023-01-18 |
US20170369572A1 (en) | 2017-12-28 |
EP3240569A4 (en) | 2018-05-30 |
SG11201705310TA (en) | 2017-07-28 |
AU2015374301B2 (en) | 2021-02-11 |
SG10202007176TA (en) | 2020-08-28 |
EA037654B1 (ru) | 2021-04-27 |
CN107530421A (zh) | 2018-01-02 |
CA2972604A1 (en) | 2016-07-07 |
EP3240569A1 (en) | 2017-11-08 |
CA2972604C (en) | 2023-07-04 |
JP2018506964A (ja) | 2018-03-15 |
ECSP17041865A (es) | 2017-08-31 |
HK1245154A1 (zh) | 2018-08-24 |
BR112017014258A2 (pt) | 2018-03-06 |
WO2016109415A1 (en) | 2016-07-07 |
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