MX2020005463A - Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer. - Google Patents

Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer.

Info

Publication number
MX2020005463A
MX2020005463A MX2020005463A MX2020005463A MX2020005463A MX 2020005463 A MX2020005463 A MX 2020005463A MX 2020005463 A MX2020005463 A MX 2020005463A MX 2020005463 A MX2020005463 A MX 2020005463A MX 2020005463 A MX2020005463 A MX 2020005463A
Authority
MX
Mexico
Prior art keywords
antibodies
treating cancer
including masked
cancer
disorders
Prior art date
Application number
MX2020005463A
Other languages
English (en)
Inventor
Michael Feldhaus
Shyra Gardai
Lori Westendorf
Matthew Levengood
Vivian Trang
Christopher Carosino
Che-Leung Law
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2020005463A publication Critical patent/MX2020005463A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan anticuerpos humanizados, incluidos anticuerpos enmascarados que se unen específicamente a CD47. Se proporcionan métodos para usar anticuerpos anti-CD47, incluidos los anticuerpos enmascarados, para modular la actividad de (por ejemplo, inhibir la proliferación de) las células que expresan un CD47, así como para el tratamiento de una o más enfermedades o trastornos (por ejemplo, cáncer) asociados con células que expresan CD47.
MX2020005463A 2017-12-01 2018-11-29 Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer. MX2020005463A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762593712P 2017-12-01 2017-12-01
PCT/US2018/062961 WO2019108733A2 (en) 2017-12-01 2018-11-29 Cd47 antibodies and uses thereof for treating cancer

Publications (1)

Publication Number Publication Date
MX2020005463A true MX2020005463A (es) 2020-09-07

Family

ID=64665131

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005463A MX2020005463A (es) 2017-12-01 2018-11-29 Anticuerpos anti grupo de diferenciacion 47 (anti-cd47) y sus usos para tratar cancer.

Country Status (17)

Country Link
US (2) US11180552B2 (es)
EP (1) EP3717515A2 (es)
JP (2) JP7391845B2 (es)
KR (1) KR20200091901A (es)
CN (1) CN111448213A (es)
AR (1) AR113862A1 (es)
AU (1) AU2018375375A1 (es)
BR (1) BR112020009805A2 (es)
CA (1) CA3083946A1 (es)
EA (1) EA202091339A1 (es)
IL (1) IL274519A (es)
MA (1) MA51208A (es)
MX (1) MX2020005463A (es)
SG (1) SG11202004864TA (es)
TW (1) TWI831759B (es)
WO (1) WO2019108733A2 (es)
ZA (1) ZA202002923B (es)

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