EA201691631A1 - Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции - Google Patents
Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляцииInfo
- Publication number
- EA201691631A1 EA201691631A1 EA201691631A EA201691631A EA201691631A1 EA 201691631 A1 EA201691631 A1 EA 201691631A1 EA 201691631 A EA201691631 A EA 201691631A EA 201691631 A EA201691631 A EA 201691631A EA 201691631 A1 EA201691631 A1 EA 201691631A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- local
- combination
- cancer immunotherapy
- immune stimulation
- systemic immune
- Prior art date
Links
- 230000000638 stimulation Effects 0.000 title abstract 2
- 230000009885 systemic effect Effects 0.000 title abstract 2
- 238000002619 cancer immunotherapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 210000005007 innate immune system Anatomy 0.000 abstract 1
- 230000002601 intratumoral effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем изобретении предлагаются композиции и способы иммунотерапии раковых заболеваний, причем в указанных способах комбинируется системная вакцинация рекомбинантным экспрессионным вектором, кодирующим вирусный антиген и/или опухолевый(е) антиген(ы), специфический(е) к раку, с целью индуцирования активированных CD8 Т-клеток путем местной (например, внутриопухолевой) стимуляции иммунной системы с использованием стандартного или модифицированного применения агониста TLR для индуцирования местных воспалительных и врожденных иммунных ответов, которые вовлекают Т-клетки в опухоль.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US201461940109P | 2014-02-14 | 2014-02-14 | |
US201461985787P | 2014-04-29 | 2014-04-29 | |
US201462022070P | 2014-07-08 | 2014-07-08 | |
US201462072548P | 2014-10-30 | 2014-10-30 | |
US201562101335P | 2015-01-08 | 2015-01-08 | |
PCT/US2015/015767 WO2015123496A1 (en) | 2014-02-14 | 2015-02-13 | Immunotherapy of cancer through combination of local and systemic immune stimulation |
Publications (2)
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EA201691631A1 true EA201691631A1 (ru) | 2017-01-30 |
EA035259B1 EA035259B1 (ru) | 2020-05-21 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA201691631A EA035259B1 (ru) | 2014-02-14 | 2015-02-13 | Иммунотерапия рака с применением комбинации местной и системной иммунной стимуляции |
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US (1) | US20160058852A1 (ru) |
EP (2) | EP3542816A1 (ru) |
JP (2) | JP6581101B2 (ru) |
AU (1) | AU2015218365A1 (ru) |
BR (1) | BR112016018521A2 (ru) |
CA (1) | CA2939093A1 (ru) |
EA (1) | EA035259B1 (ru) |
ES (1) | ES2738582T3 (ru) |
IL (1) | IL247066B (ru) |
MX (1) | MX2016010565A (ru) |
SG (1) | SG11201606625RA (ru) |
WO (1) | WO2015123496A1 (ru) |
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2015
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- 2015-02-13 AU AU2015218365A patent/AU2015218365A1/en not_active Abandoned
- 2015-02-13 EA EA201691631A patent/EA035259B1/ru not_active IP Right Cessation
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- 2015-02-13 JP JP2016551828A patent/JP6581101B2/ja not_active Expired - Fee Related
- 2015-02-13 US US14/621,685 patent/US20160058852A1/en not_active Abandoned
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US20160058852A1 (en) | 2016-03-03 |
EP3104878B1 (en) | 2019-05-22 |
EA035259B1 (ru) | 2020-05-21 |
SG11201606625RA (en) | 2016-09-29 |
CA2939093A1 (en) | 2015-08-20 |
MX2016010565A (es) | 2017-05-10 |
EP3542816A1 (en) | 2019-09-25 |
IL247066B (en) | 2020-11-30 |
IL247066A0 (en) | 2016-09-29 |
JP2019203013A (ja) | 2019-11-28 |
WO2015123496A1 (en) | 2015-08-20 |
BR112016018521A2 (pt) | 2017-10-17 |
JP2017506641A (ja) | 2017-03-09 |
JP6581101B2 (ja) | 2019-09-25 |
AU2015218365A1 (en) | 2016-09-01 |
ES2738582T3 (es) | 2020-01-23 |
EP3104878A1 (en) | 2016-12-21 |
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