TR201819571T4 - Hem immün hücrelerde hem de patolojik hücrelerde bulunan antijenleri hedef almak amacıyla değiştirilmiş immünoterapiye yönelik hücreler. - Google Patents
Hem immün hücrelerde hem de patolojik hücrelerde bulunan antijenleri hedef almak amacıyla değiştirilmiş immünoterapiye yönelik hücreler.Info
- Publication number
- TR201819571T4 TR201819571T4 TR2018/19571T TR201819571T TR201819571T4 TR 201819571 T4 TR201819571 T4 TR 201819571T4 TR 2018/19571 T TR2018/19571 T TR 2018/19571T TR 201819571 T TR201819571 T TR 201819571T TR 201819571 T4 TR201819571 T4 TR 201819571T4
- Authority
- TR
- Turkey
- Prior art keywords
- cells
- immunotherapy
- pathological
- immune cells
- modified
- Prior art date
Links
- 210000002865 immune cell Anatomy 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 title abstract 3
- 238000009169 immunotherapy Methods 0.000 title abstract 2
- 230000001575 pathological effect Effects 0.000 title abstract 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 abstract 1
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 abstract 1
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 abstract 1
- 102100025221 CD70 antigen Human genes 0.000 abstract 1
- 108091033409 CRISPR Proteins 0.000 abstract 1
- 102100028801 Calsyntenin-1 Human genes 0.000 abstract 1
- 108010042407 Endonucleases Proteins 0.000 abstract 1
- 102000004533 Endonucleases Human genes 0.000 abstract 1
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 abstract 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 abstract 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 abstract 1
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 abstract 1
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 abstract 1
- 238000010459 TALEN Methods 0.000 abstract 1
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/463—Cellular immunotherapy characterised by recombinant expression
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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- A61K39/4644—Cancer antigens
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- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464429—Molecules with a "CD" designation not provided for elsewhere
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- A61K39/4643—Vertebrate antigens
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- A61K39/464436—Cytokines
- A61K39/464438—Tumor necrosis factors [TNF], CD70
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2510/00—Genetically modified cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Buluş, hem patolojik hücrelerde hem de immün hücrelerde (örn. CD38, CSl veya CD70) ortak olan bir antijen belirtecini, söz konusu belirteçleri kodlayan genlerin söz konusu immün hücrelerde TALEN, Cas9 veya argonaut gibi bir nadir kesici endonükleaz ile etkisizleştirilmesinden dolayı hedef alan kimerik antijen reseptörleriyle donatılabilen, immünoterapiye yönelik genetiği değiştirilmiş immün hücrelerin geliştirilmesine ilişkin yöntemler ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201470076 | 2014-02-14 |
Publications (1)
Publication Number | Publication Date |
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TR201819571T4 true TR201819571T4 (tr) | 2019-01-21 |
Family
ID=50114255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2018/19571T TR201819571T4 (tr) | 2014-02-14 | 2015-02-13 | Hem immün hücrelerde hem de patolojik hücrelerde bulunan antijenleri hedef almak amacıyla değiştirilmiş immünoterapiye yönelik hücreler. |
Country Status (19)
Country | Link |
---|---|
US (3) | US10836998B2 (tr) |
EP (2) | EP3105317B1 (tr) |
JP (1) | JP6673838B2 (tr) |
KR (1) | KR102157924B1 (tr) |
CN (1) | CN106029875A (tr) |
AU (1) | AU2015216875B2 (tr) |
BR (1) | BR112016017806B1 (tr) |
CA (1) | CA2937711C (tr) |
DK (1) | DK3105317T3 (tr) |
ES (1) | ES2711498T3 (tr) |
HU (1) | HUE041497T2 (tr) |
IL (1) | IL246645B (tr) |
MX (1) | MX2016010345A (tr) |
NO (1) | NO20161276A1 (tr) |
PL (1) | PL3105317T3 (tr) |
PT (1) | PT3105317T (tr) |
RU (1) | RU2714258C2 (tr) |
TR (1) | TR201819571T4 (tr) |
WO (1) | WO2015121454A1 (tr) |
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WO2015121454A1 (en) | 2015-08-20 |
JP2017506636A (ja) | 2017-03-09 |
BR112016017806A2 (pt) | 2017-10-10 |
US20180201901A1 (en) | 2018-07-19 |
US11692169B2 (en) | 2023-07-04 |
NO20161276A1 (en) | 2016-08-09 |
IL246645B (en) | 2021-02-28 |
EP3105317B1 (en) | 2018-09-19 |
KR102157924B1 (ko) | 2020-10-26 |
KR20160138404A (ko) | 2016-12-05 |
US20200407682A1 (en) | 2020-12-31 |
US20230357719A1 (en) | 2023-11-09 |
JP6673838B2 (ja) | 2020-04-01 |
PL3105317T3 (pl) | 2019-02-28 |
PT3105317T (pt) | 2019-02-27 |
AU2015216875B2 (en) | 2021-02-25 |
IL246645A0 (en) | 2016-08-31 |
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