BR112016017806A2 - células para imunoterapia engenheiradas para direcionamento de antígeno presente em ambas as células imunes e células patológicas - Google Patents

células para imunoterapia engenheiradas para direcionamento de antígeno presente em ambas as células imunes e células patológicas

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Publication number
BR112016017806A2
BR112016017806A2 BR112016017806A BR112016017806A BR112016017806A2 BR 112016017806 A2 BR112016017806 A2 BR 112016017806A2 BR 112016017806 A BR112016017806 A BR 112016017806A BR 112016017806 A BR112016017806 A BR 112016017806A BR 112016017806 A2 BR112016017806 A2 BR 112016017806A2
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Brazil
Prior art keywords
cells
pathological
immune cells
antigen present
targeting antigen
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BR112016017806A
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English (en)
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BR112016017806B1 (pt
Inventor
Poirot Laurent
Duchateau Philippe
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Cellectis
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Application filed by Cellectis filed Critical Cellectis
Publication of BR112016017806A2 publication Critical patent/BR112016017806A2/pt
Publication of BR112016017806B1 publication Critical patent/BR112016017806B1/pt

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    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • A61K39/4644—Cancer antigens
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/4643—Vertebrate antigens
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    • C12N5/0634—Cells from the blood or the immune system
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

métodos de desenvolver células imunes geneticamente engenheiradas para imunoterapia, que podem ser dotadas com receptores de antígeno quimérico que têm como alvo um marcador de antígeno que é comum a ambas as células patológicas e referidas células imunes (ex: cd38, cs1 ou cd70), pelo fato que os genes que codificam referidos marcadores são inativados nas referidas células imunes por uma endonuclease de corte incomum, tais como talen, cas9, ou argonaute.
BR112016017806-8A 2014-02-14 2015-02-13 Uso de células t engenheiradas para imunoterapia contra células patológicas, e método ex vivo para preparação das mesmas BR112016017806B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201470076 2014-02-14
DKPA201470076 2014-02-14
PCT/EP2015/053162 WO2015121454A1 (en) 2014-02-14 2015-02-13 Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells

Publications (2)

Publication Number Publication Date
BR112016017806A2 true BR112016017806A2 (pt) 2017-10-10
BR112016017806B1 BR112016017806B1 (pt) 2023-05-02

Family

ID=50114255

Family Applications (1)

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BR112016017806-8A BR112016017806B1 (pt) 2014-02-14 2015-02-13 Uso de células t engenheiradas para imunoterapia contra células patológicas, e método ex vivo para preparação das mesmas

Country Status (19)

Country Link
US (3) US10836998B2 (pt)
EP (2) EP3105317B1 (pt)
JP (1) JP6673838B2 (pt)
KR (1) KR102157924B1 (pt)
CN (1) CN106029875A (pt)
AU (1) AU2015216875B2 (pt)
BR (1) BR112016017806B1 (pt)
CA (1) CA2937711C (pt)
DK (1) DK3105317T3 (pt)
ES (1) ES2711498T3 (pt)
HU (1) HUE041497T2 (pt)
IL (1) IL246645B (pt)
MX (1) MX2016010345A (pt)
NO (1) NO20161276A1 (pt)
PL (1) PL3105317T3 (pt)
PT (1) PT3105317T (pt)
RU (1) RU2714258C2 (pt)
TR (1) TR201819571T4 (pt)
WO (1) WO2015121454A1 (pt)

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US11730797B2 (en) 2014-12-05 2023-08-22 City Of Hope CS1 targeted chimeric antigen receptor-modified T cells

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