MX2017002134A - Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes. - Google Patents

Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes.

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Publication number
MX2017002134A
MX2017002134A MX2017002134A MX2017002134A MX2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A
Authority
MX
Mexico
Prior art keywords
multifunctionality
immune cells
immune cell
biguanide
buformin
Prior art date
Application number
MX2017002134A
Other languages
English (en)
Inventor
Udono Heiichiro
Eikawa Shingo
TOYOOKA Shin-ichi
Original Assignee
Nat Univ Corporation Okayama Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Corporation Okayama Univ filed Critical Nat Univ Corporation Okayama Univ
Publication of MX2017002134A publication Critical patent/MX2017002134A/es

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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
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  • Epidemiology (AREA)
  • Biotechnology (AREA)
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  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Rehabilitation Therapy (AREA)
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Abstract

La presente invención proporciona un método para mejorar la función de células inmunes al reactivar varias células ex vivo y proporciona células inmunes con función mejorada; la invención adicionalmente proporciona un método de evaluación de multifuncionalidad relacionado a células inmunes; un fármaco antidiabético de biguanida seleccionado de metformina, fenformína, y buformina es capaz de mejorar la multifuncionalidad de células inmunes al incrementar células TCD8+ que tienen una alta habilidad para producir IL-2, TNF-a, e IFN?; la multifuncionalidad de células inmunes puede ser evaluada al comparar células inmunes tratadas con un fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina, contra células inmunes control que no fueron tratadas con el fármaco antidiabético de biguanida; cuando la multifuncionalidad de células inmunes tratadas con el fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina se determina que es incrementada significativamente en comparación con el control, se puede evaluar que la sensibilidad de las células inmunes al agente terapéutico es mejorada.
MX2017002134A 2014-08-19 2015-08-17 Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes. MX2017002134A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014166593 2014-08-19
JP2015085556 2015-04-20
PCT/JP2015/073011 WO2016027764A1 (ja) 2014-08-19 2015-08-17 免疫細胞の機能増強方法及び免疫細胞の多機能性評価方法

Publications (1)

Publication Number Publication Date
MX2017002134A true MX2017002134A (es) 2017-09-13

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MX2017002134A MX2017002134A (es) 2014-08-19 2015-08-17 Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes.

Country Status (15)

Country Link
US (2) US20170231929A1 (es)
EP (2) EP3192517A4 (es)
JP (3) JP6629211B2 (es)
KR (1) KR20170042778A (es)
CN (1) CN107148274A (es)
AU (1) AU2015304448B2 (es)
BR (1) BR112017002807A2 (es)
CA (1) CA2958573A1 (es)
ES (1) ES2915849T3 (es)
IL (1) IL250639B (es)
MX (1) MX2017002134A (es)
PH (1) PH12017500224A1 (es)
RU (2) RU2020127099A (es)
SG (2) SG10202005315SA (es)
WO (1) WO2016027764A1 (es)

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CR20160319A (es) 2013-12-12 2016-11-08 Jiangsu Hengrui Medicine Co Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este
CN117586403A (zh) 2016-10-11 2024-02-23 艾吉纳斯公司 抗lag-3抗体及其使用方法
CN107082812B (zh) 2017-03-29 2018-11-13 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
BR112019025478A8 (pt) * 2017-06-02 2022-12-06 Bayer Ag Combinação de regorafenib e inibidores de pd-1/pd-l1(2) para tratamento de câncer
JPWO2019069449A1 (ja) * 2017-10-06 2019-11-14 純児 赤木 測定方法
JPWO2019124423A1 (ja) * 2017-12-19 2020-10-22 国立大学法人 岡山大学 がんの進行抑制、治療、予防及び／又は再発予防剤
JP2019112353A (ja) * 2017-12-25 2019-07-11 合同会社チューモス 自家腫瘍ワクチン及び免疫誘導方法
US11959916B2 (en) * 2017-12-26 2024-04-16 Tamio Yamauchi Method, system, and program for supplying immunodynamics-related information
IL264068B2 (en) * 2018-01-05 2023-07-01 Great Novel Therapeutics Biotech & Medicals Corp Aggregate and pharmaceutical preparation containing an hdac inhibitor and an nsaid aggregate together with an immune checkpoint inhibitor for use in a method for removing immunosuppression in the microenvironment of a tumor or stimulating an immune system against cancer cells
WO2019202473A1 (en) * 2018-04-16 2019-10-24 Université de Lausanne Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade
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