SG10201803094QA - Monoliths with attached recognition compounds, arrays thereof and uses thereof - Google Patents

Monoliths with attached recognition compounds, arrays thereof and uses thereof

Info

Publication number
SG10201803094QA
SG10201803094QA SG10201803094QA SG10201803094QA SG10201803094QA SG 10201803094Q A SG10201803094Q A SG 10201803094QA SG 10201803094Q A SG10201803094Q A SG 10201803094QA SG 10201803094Q A SG10201803094Q A SG 10201803094QA SG 10201803094Q A SG10201803094Q A SG 10201803094QA
Authority
SG
Singapore
Prior art keywords
monoliths
arrays
recognition compounds
attached recognition
attached
Prior art date
Application number
SG10201803094QA
Inventor
Pehr Harbury
Madan Paidhungat
Robin Prince
Original Assignee
Dice Molecules Sv Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dice Molecules Sv Llc filed Critical Dice Molecules Sv Llc
Publication of SG10201803094QA publication Critical patent/SG10201803094QA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00504—Pins
    • B01J2219/00509—Microcolumns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

MONOLITHS WITH ATTACHED RECOGNITION COMPOUNDS, ARRAYS THEREOF AND USES THEREOF Provided herein are monoliths with attached recognition compounds which 5 selectively bind ligands, methods of preparing such monoliths, arrays thereof and uses thereof. For example, monoliths provide herein can be used in columns and arrays thereof. (FIG. 4)
SG10201803094QA 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof SG10201803094QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461932747P 2014-01-28 2014-01-28
US201462006845P 2014-06-02 2014-06-02

Publications (1)

Publication Number Publication Date
SG10201803094QA true SG10201803094QA (en) 2018-06-28

Family

ID=53678148

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SG10201803094QA SG10201803094QA (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof
SG11201606921PA SG11201606921PA (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof

Family Applications After (1)

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Country Status (16)

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US (3) US10358641B2 (en)
EP (1) EP3099799B1 (en)
JP (1) JP6602772B2 (en)
KR (1) KR20160122174A (en)
CN (1) CN106459978B (en)
AU (1) AU2015211020A1 (en)
BR (1) BR112016017152A2 (en)
CA (1) CA2940526A1 (en)
DK (1) DK3099799T3 (en)
ES (1) ES2732054T3 (en)
HK (1) HK1231511A1 (en)
IL (1) IL246784A0 (en)
MX (1) MX369674B (en)
RU (1) RU2016132972A (en)
SG (2) SG10201803094QA (en)
WO (1) WO2015116739A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
JP7033923B2 (en) * 2016-01-08 2022-03-11 株式会社ジーンデザイン Carrier for nucleic acid synthesis using an inorganic porous body produced by the sol-gel method
EP3464590A4 (en) * 2016-06-05 2020-04-01 Dice Molecules SV, LLC Methods of routing, compositions and uses thereof
EP3837344A4 (en) * 2018-08-17 2022-01-26 Sierra Biosystems, Inc. Row-independent oligonucleotide synthesis
CN110724623A (en) * 2019-09-10 2020-01-24 深圳市百迈生命科学有限公司 1536 well solid phase synthesis and extraction plate

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1123878A (en) 1966-08-23 1968-08-14 Ici Ltd Synthesis of norbornene derivatives
US4889632A (en) 1987-12-10 1989-12-26 Ceskoslovenska Akademie Ved Macroporous polymeric membranes for the separation of polymers and a method of their application
WO1992007882A1 (en) 1990-10-26 1992-05-14 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5281368A (en) 1992-03-31 1994-01-25 Exxon Chemical Patents Inc. Norbornene polymerization initiators and process for preparing same
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
CN1268979A (en) 1997-07-22 2000-10-04 拉普吉恩公司 Multiple functionilities within an array element and uses thereof
JP4883837B2 (en) 1998-06-12 2012-02-22 ウォーターズ・テクノロジーズ・コーポレーション A novel ion-exchange porous resin for solid-phase extraction and chromatography
US6238565B1 (en) 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules
AU1318400A (en) * 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6919181B2 (en) 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
US7473367B2 (en) 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
WO2004064974A2 (en) * 2003-01-17 2004-08-05 Northeastern University Narrow i.d. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules
US20050095602A1 (en) 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
US8586350B2 (en) 2004-02-12 2013-11-19 Gl Sciences Incorporated Mechanism of separating and purifying DNA and the like
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
JP2006015333A (en) 2004-05-31 2006-01-19 Showa Denko Kk Organic polymer monolith, and production method and production application therefor
EP1786552A1 (en) * 2004-08-27 2007-05-23 Applera Corporation Method of making polymer monolith composite substrate and resulting substrate as well as beads and bead array
WO2006047791A2 (en) * 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
US8394492B1 (en) 2004-10-28 2013-03-12 The United States Of America As Represented By The United States National Aeronautics And Space Administration Surface modified aerogel monoliths
CN101400993A (en) 2005-11-10 2009-04-01 阿普尔拉股份有限公司 Microfluidic systems including porous polymer electrodes
DE102005059315A1 (en) 2005-12-09 2007-06-14 Qiagen Gmbh Process for the enrichment of short-chain nucleic acids
EP2041318A2 (en) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
GB0614727D0 (en) 2006-07-25 2006-09-06 Chromatide Ltd Solid support
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
WO2008130186A2 (en) 2007-04-23 2008-10-30 Lg Chem, Ltd. A retardation film, a method for preparing retardation film and polarizer comprising the retardation film
JP4840514B2 (en) 2007-10-17 2011-12-21 株式会社島津製作所 Monolith separation medium for chromatography and method for producing the same
EP2174916B9 (en) 2008-10-09 2017-11-22 Université Des Sciences Et Technologies De Lille Highly pure silica monoliths and method of synthesizing same
CN102272363A (en) 2008-11-06 2011-12-07 新加坡科技研究局 Apparatus for biopolymer synthesis
EP2335820A1 (en) 2009-12-18 2011-06-22 Leopold-Franzens-Universität Innsbruck Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces
EP2521612B1 (en) 2010-01-08 2017-05-17 University Of Tasmania Use of porous polymer monoliths
US20110240541A1 (en) 2010-04-06 2011-10-06 Binghe Gu Monolithic column technology for liquid chromatography
EP2571892A2 (en) 2010-05-18 2013-03-27 AbbVie Inc. Apparatus and process of purification of proteins
US8603833B2 (en) 2010-06-03 2013-12-10 University Of South Florida Germania-silica-based sol-gel monolith and uses thereof
ES2510766T3 (en) 2010-06-08 2014-10-21 Firmenich Sa Bicyclo-ketones as perfuming ingredients
EP2405000A1 (en) 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
US20150315569A1 (en) 2014-05-02 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method for screening a nucleic acid-programmed small molecule library

Also Published As

Publication number Publication date
KR20160122174A (en) 2016-10-21
CN106459978B (en) 2020-05-19
HK1231511A1 (en) 2017-12-22
BR112016017152A2 (en) 2017-08-08
WO2015116739A1 (en) 2015-08-06
US10358641B2 (en) 2019-07-23
EP3099799A4 (en) 2017-09-20
AU2015211020A2 (en) 2016-08-25
US20150209753A1 (en) 2015-07-30
JP2017503522A (en) 2017-02-02
RU2016132972A (en) 2018-03-05
JP6602772B2 (en) 2019-11-06
AU2015211020A1 (en) 2016-08-11
EP3099799A1 (en) 2016-12-07
CN106459978A (en) 2017-02-22
SG11201606921PA (en) 2016-10-28
MX2016009798A (en) 2017-02-28
US20180179517A9 (en) 2018-06-28
US20170191056A1 (en) 2017-07-06
DK3099799T3 (en) 2019-07-01
US20190270985A1 (en) 2019-09-05
IL246784A0 (en) 2016-08-31
EP3099799B1 (en) 2019-05-15
MX369674B (en) 2019-11-15
CA2940526A1 (en) 2015-08-06
ES2732054T3 (en) 2019-11-20

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