JP2017513472A5 - - Google Patents
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- JP2017513472A5 JP2017513472A5 JP2016561746A JP2016561746A JP2017513472A5 JP 2017513472 A5 JP2017513472 A5 JP 2017513472A5 JP 2016561746 A JP2016561746 A JP 2016561746A JP 2016561746 A JP2016561746 A JP 2016561746A JP 2017513472 A5 JP2017513472 A5 JP 2017513472A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- immune cell
- engineered immune
- rare
- endonuclease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000002865 immune cell Anatomy 0.000 claims description 57
- 102100031780 Endonuclease Human genes 0.000 claims description 35
- 108010042407 Endonucleases Proteins 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 101000926525 Homo sapiens eIF-2-alpha kinase GCN2 Proteins 0.000 claims description 16
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 12
- 108010009975 Positive Regulatory Domain I-Binding Factor 1 Proteins 0.000 claims description 12
- 102100034175 eIF-2-alpha kinase GCN2 Human genes 0.000 claims description 12
- 230000000415 inactivating effect Effects 0.000 claims description 12
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 8
- 108091008874 T cell receptors Proteins 0.000 claims description 8
- 230000007018 DNA scission Effects 0.000 claims description 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 5
- 108091033409 CRISPR Proteins 0.000 claims description 4
- 230000003211 malignant effect Effects 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 102000004452 Arginase Human genes 0.000 claims description 2
- 108700024123 Arginases Proteins 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims description 2
- 230000007017 scission Effects 0.000 claims description 2
- 102100024894 PR domain zinc finger protein 1 Human genes 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 102000009844 Positive Regulatory Domain I-Binding Factor 1 Human genes 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 101000687344 Homo sapiens PR domain zinc finger protein 1 Proteins 0.000 description 4
- 102000049001 human EIF2AK4 Human genes 0.000 description 4
- 102000043685 human PRDM1 Human genes 0.000 description 4
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 2
- 101001005269 Arabidopsis thaliana Ceramide synthase 1 LOH3 Proteins 0.000 description 2
- 101001005312 Arabidopsis thaliana Ceramide synthase LOH1 Proteins 0.000 description 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 2
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
- 102100028801 Calsyntenin-1 Human genes 0.000 description 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 description 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 description 2
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 description 2
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 description 2
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 description 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 description 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 2
- 101000668858 Spinacia oleracea 30S ribosomal protein S1, chloroplastic Proteins 0.000 description 2
- 101000898746 Streptomyces clavuligerus Clavaminate synthase 1 Proteins 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100033579 Trophoblast glycoprotein Human genes 0.000 description 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470209 | 2014-04-11 | ||
| DKPA201470209 | 2014-04-11 | ||
| PCT/EP2015/057865 WO2015155341A1 (en) | 2014-04-11 | 2015-04-10 | Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017513472A JP2017513472A (ja) | 2017-06-01 |
| JP2017513472A5 true JP2017513472A5 (enExample) | 2018-05-31 |
Family
ID=58805110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016561746A Pending JP2017513472A (ja) | 2014-04-11 | 2015-04-10 | アルギニンおよび／またはトリプトファン枯渇微小環境に対して抵抗性を有する免疫細胞を作製するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10765728B2 (enExample) |
| EP (1) | EP3129473B8 (enExample) |
| JP (1) | JP2017513472A (enExample) |
| AU (1) | AU2015245469B2 (enExample) |
| CA (1) | CA2945238C (enExample) |
| WO (1) | WO2015155341A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
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| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
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| BR112017008693A2 (pt) | 2014-10-31 | 2018-02-27 | The Trustees Of The University Of Pennsylvania | célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. |
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| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
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| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
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| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
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| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| CA3037387A1 (en) | 2016-10-13 | 2018-04-19 | Juno Therapeutics, Inc. | Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| JP2020513248A (ja) | 2016-10-19 | 2020-05-14 | フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． | 音響による親和性細胞抽出 |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
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| CN107043775B (zh) * | 2017-04-24 | 2020-06-16 | 中国农业科学院生物技术研究所 | 一种能促进棉花侧根发育的sgRNA及其应用 |
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| CN107177632B (zh) * | 2017-05-27 | 2020-02-07 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用 |
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| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
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| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001342T5 (de) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| GB2614813B (en) | 2020-05-08 | 2025-05-07 | Harvard College | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
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| CN112871212B (zh) * | 2021-03-11 | 2022-09-13 | 福州大学 | 一种基于精氨酸适配体的光催化剂的制备方法及应用 |
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-
2015
- 2015-04-10 US US15/302,913 patent/US10765728B2/en active Active
- 2015-04-10 WO PCT/EP2015/057865 patent/WO2015155341A1/en not_active Ceased
- 2015-04-10 EP EP15715273.7A patent/EP3129473B8/en active Active
- 2015-04-10 CA CA2945238A patent/CA2945238C/en active Active
- 2015-04-10 JP JP2016561746A patent/JP2017513472A/ja active Pending
- 2015-04-10 AU AU2015245469A patent/AU2015245469B2/en active Active
-
2020
- 2020-08-13 US US16/993,160 patent/US12171820B2/en active Active
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