JP2018500006A5 - - Google Patents
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- JP2018500006A5 JP2018500006A5 JP2017523296A JP2017523296A JP2018500006A5 JP 2018500006 A5 JP2018500006 A5 JP 2018500006A5 JP 2017523296 A JP2017523296 A JP 2017523296A JP 2017523296 A JP2017523296 A JP 2017523296A JP 2018500006 A5 JP2018500006 A5 JP 2018500006A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- modified
- chain
- cells
- crispr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091008874 T cell receptors Proteins 0.000 claims 55
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 55
- 210000001744 T-lymphocyte Anatomy 0.000 claims 28
- 238000010354 CRISPR gene editing Methods 0.000 claims 17
- 108091033409 CRISPR Proteins 0.000 claims 14
- 238000012217 deletion Methods 0.000 claims 12
- 230000037430 deletion Effects 0.000 claims 12
- 238000003780 insertion Methods 0.000 claims 12
- 230000037431 insertion Effects 0.000 claims 12
- 230000001404 mediated effect Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 230000000139 costimulatory effect Effects 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 230000011664 signaling Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 230000002222 downregulating effect Effects 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000004520 electroporation Methods 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 238000009172 cell transfer therapy Methods 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073651P | 2014-10-31 | 2014-10-31 | |
| US62/073,651 | 2014-10-31 | ||
| PCT/US2015/055780 WO2016069282A1 (en) | 2014-10-31 | 2015-10-15 | Altering gene expression in modified t cells and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018500006A JP2018500006A (ja) | 2018-01-11 |
| JP2018500006A5 true JP2018500006A5 (enExample) | 2018-11-22 |
Family
ID=55858177
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523296A Ceased JP2018500006A (ja) | 2014-10-31 | 2015-10-15 | 改変ｔ細胞における遺伝子発現の改変およびその使用 |
| JP2017523279A Active JP6879910B2 (ja) | 2014-10-31 | 2015-10-15 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2020208069A Pending JP2021058196A (ja) | 2014-10-31 | 2020-12-16 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2023004286A Active JP7657474B2 (ja) | 2014-10-31 | 2023-01-16 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2025043131A Pending JP2025089344A (ja) | 2014-10-31 | 2025-03-18 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523279A Active JP6879910B2 (ja) | 2014-10-31 | 2015-10-15 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2020208069A Pending JP2021058196A (ja) | 2014-10-31 | 2020-12-16 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2023004286A Active JP7657474B2 (ja) | 2014-10-31 | 2023-01-16 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
| JP2025043131A Pending JP2025089344A (ja) | 2014-10-31 | 2025-03-18 | Ｃａｒｔ細胞における遺伝子発現の改変およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US11208661B2 (enExample) |
| EP (4) | EP4427809A3 (enExample) |
| JP (5) | JP2018500006A (enExample) |
| KR (5) | KR20240075936A (enExample) |
| CN (3) | CN114836385B (enExample) |
| AU (4) | AU2015339744B2 (enExample) |
| BR (1) | BR112017008693A2 (enExample) |
| CA (2) | CA2964948A1 (enExample) |
| EA (1) | EA201790953A1 (enExample) |
| ES (1) | ES2983094T3 (enExample) |
| MX (2) | MX2017005698A (enExample) |
| PL (1) | PL3215166T3 (enExample) |
| WO (2) | WO2016069283A1 (enExample) |
Families Citing this family (205)
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| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
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