BR112017008693A2 - célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. - Google Patents

célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição.

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Publication number
BR112017008693A2
BR112017008693A2 BR112017008693-0A BR112017008693A BR112017008693A2 BR 112017008693 A2 BR112017008693 A2 BR 112017008693A2 BR 112017008693 A BR112017008693 A BR 112017008693A BR 112017008693 A2 BR112017008693 A2 BR 112017008693A2
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Brazil
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cell
modified
methods
generating
condition
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BR112017008693-0A
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English (en)
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Zhao Yangbing
Ren Jiangtao
Liu Xiaojun
H. June Carl
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The Trustees Of The University Of Pennsylvania
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Publication of BR112017008693A2 publication Critical patent/BR112017008693A2/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

a presente invenção se refere às composições e métodos para gerar uma célula t modificada com um ácido nucleico capaz de infrarregular a expressão de gene endógeno selecionado a partir do grupo que consiste em cadeia ¿ de tcr, cadeia ß de tcr, beta-2 microglobulina, uma molécula hla, ctla-4, pd1, e fas e compreendendo adicionalmente um ácido nucleico codificando um receptor de célula t (tcr) modificado compreendendo afinidade para um antígeno de superfície em uma célula alvo ou um ácido nucleico eletroporado codificando um receptor antigênico quimérico (car). também são incluídos métodos e composições farmacêuticas compreendendo a célula t modificada para terapia adotiva e tratamento de uma condição, tal como uma doença autoimune.
BR112017008693-0A 2014-10-31 2015-10-15 célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. BR112017008693A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462073651P 2014-10-31 2014-10-31
US62/073651 2014-10-31
PCT/US2015/055799 WO2016069283A1 (en) 2014-10-31 2015-10-15 Altering gene expression in cart cells and uses thereof

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BR112017008693A2 true BR112017008693A2 (pt) 2018-02-27

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US (6) US11208661B2 (pt)
EP (3) EP3215166A4 (pt)
JP (4) JP6879910B2 (pt)
KR (3) KR102546296B1 (pt)
CN (3) CN107249606A (pt)
AU (3) AU2015339744B2 (pt)
BR (1) BR112017008693A2 (pt)
CA (2) CA2964948A1 (pt)
EA (1) EA201790953A1 (pt)
HK (1) HK1243332A1 (pt)
MX (2) MX2017005698A (pt)
WO (2) WO2016069283A1 (pt)

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