BR112019021857A2 - Métodos e composições de célula t aperfeiçoada - Google Patents

Métodos e composições de célula t aperfeiçoada Download PDF

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Publication number
BR112019021857A2
BR112019021857A2 BR112019021857-2A BR112019021857A BR112019021857A2 BR 112019021857 A2 BR112019021857 A2 BR 112019021857A2 BR 112019021857 A BR112019021857 A BR 112019021857A BR 112019021857 A2 BR112019021857 A2 BR 112019021857A2
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compositions
cells
methods
perfected
car
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BR112019021857-2A
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Fernando Chaparro Riggers Javier
John Van Blarcom Thomas
Andre Boldajipour Bijan
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Allogene Therapeutics, Inc.
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Publication of BR112019021857A2 publication Critical patent/BR112019021857A2/pt

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
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    • A61K39/46434—Antigens related to induction of tolerance to non-self
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0602—Vertebrate cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

a presente invenção fornece composições e métodos que regulam de forma descendente a expressão da superfície celular das moléculas principais de histocompatibilidade classe i e o uso de tais composições e métodos para melhorar as atividades funcionais de células t isoladas (por exemplo, células t específicas de antígeno modificado por gene, como células t receptoras de antígeno quimérico (car-t)). em particular, a presente invenção fornece métodos e composições para reforçar a eficácia terapêutica das células car-t.
BR112019021857-2A 2017-04-19 2018-04-18 Métodos e composições de célula t aperfeiçoada BR112019021857A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487215P 2017-04-19 2017-04-19
US62/487,215 2017-04-19
PCT/IB2018/052698 WO2018193394A1 (en) 2017-04-19 2018-04-18 Improved t cell compositions and methods

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BR112019021857A2 true BR112019021857A2 (pt) 2020-06-02

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BR112019021857-2A BR112019021857A2 (pt) 2017-04-19 2018-04-18 Métodos e composições de célula t aperfeiçoada

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US (1) US20200399343A1 (pt)
EP (1) EP3612275A1 (pt)
JP (2) JP2020517244A (pt)
KR (1) KR20190141206A (pt)
CN (1) CN110520196A (pt)
AU (1) AU2018255926B9 (pt)
BR (1) BR112019021857A2 (pt)
CA (1) CA3057265A1 (pt)
IL (1) IL269334A (pt)
MX (1) MX2019012360A (pt)
RU (1) RU2019136640A (pt)
TW (1) TWI694149B (pt)
WO (1) WO2018193394A1 (pt)

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US20220249558A1 (en) 2019-04-30 2022-08-11 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
MX2022000016A (es) * 2019-06-27 2022-02-24 Crispr Therapeutics Ag Uso de linfocitos t con receptor de antigeno quimerico e inhibidores de linfocitos citoliticos naturales para el tratamiento del cancer.
AU2020339559A1 (en) * 2019-08-28 2022-04-14 Nanjing Legend Biotech Co., Ltd. Engineered T cells and methods of producing thereof
US20210253712A1 (en) * 2020-01-30 2021-08-19 ST Phi Therapeutics Universal T Cells and the Method of Use Thereof
CN115516086A (zh) * 2020-05-13 2022-12-23 南京传奇生物科技有限公司 类猿icp47及变体减少同种异体细胞宿主排斥的组合物及方法
US20230405047A1 (en) 2020-11-09 2023-12-21 Miltenyi Biotec B.V. & Co. KG Methods and compositions for eliminating engineered immune cells
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WO2023141472A2 (en) * 2022-01-19 2023-07-27 Nkarta, Inc. Engineered immune cells with enhanced potency and uses of same in immunotherapy

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Publication number Publication date
RU2019136640A (ru) 2021-05-19
IL269334A (en) 2019-11-28
WO2018193394A1 (en) 2018-10-25
JP2020517244A (ja) 2020-06-18
RU2019136640A3 (pt) 2021-12-16
US20200399343A1 (en) 2020-12-24
TWI694149B (zh) 2020-05-21
AU2018255926B2 (en) 2023-10-12
AU2018255926B9 (en) 2023-10-19
CA3057265A1 (en) 2018-10-25
AU2018255926A1 (en) 2019-10-10
CN110520196A (zh) 2019-11-29
EP3612275A1 (en) 2020-02-26
JP2023086732A (ja) 2023-06-22
KR20190141206A (ko) 2019-12-23
TW201903143A (zh) 2019-01-16
MX2019012360A (es) 2019-11-28

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