CN115003802A - 一种经修饰的免疫效应细胞及其制备方法 - Google Patents

一种经修饰的免疫效应细胞及其制备方法 Download PDF

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CN115003802A
CN115003802A CN202080090688.0A CN202080090688A CN115003802A CN 115003802 A CN115003802 A CN 115003802A CN 202080090688 A CN202080090688 A CN 202080090688A CN 115003802 A CN115003802 A CN 115003802A
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gene
immune effector
cell
hla
effector cell
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尚小云
蒋海娟
王丹
沈慧
马丽
辛雨
徐凡丽
李甲璐
马少文
赵丹
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Ningbo Maoxing Biomedical Technology Co ltd
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Ningbo Maoxing Biomedical Technology Co ltd
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Abstract

提供了一种经修饰的免疫效应细胞，其中与未经所述修饰的相应细胞中相应基因的表达和/或活性相比，TRAC基因和HLA‑A基因的表达和/或活性被下调，B2M基因的表达和/或活性未被下调，且CIITA基因的表达和/或活性未被下调。提供制备所述的经修饰的免疫效应细胞的方法。

Description

PCT国内申请，说明书已公开。

Claims (49)

  1. PCT国内申请，权利要求书已公开。
CN202080090688.0A 2020-01-02 2020-12-29 一种经修饰的免疫效应细胞及其制备方法 Pending CN115003802A (zh)

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WO2023274386A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向egfr的通用型car-t细胞及其制备方法
CA3224476A1 (en) * 2021-07-01 2023-01-05 Xiaoyun SHANG Antigen-binding polypeptide targeting b7h3 and application thereof
WO2023274387A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向gd2的通用型car-t细胞及其制备方法和应用
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