BR112016023513A2 - expressão de transgene relacionada com fármacos - Google Patents

expressão de transgene relacionada com fármacos

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Publication number
BR112016023513A2
BR112016023513A2 BR112016023513A BR112016023513A BR112016023513A2 BR 112016023513 A2 BR112016023513 A2 BR 112016023513A2 BR 112016023513 A BR112016023513 A BR 112016023513A BR 112016023513 A BR112016023513 A BR 112016023513A BR 112016023513 A2 BR112016023513 A2 BR 112016023513A2
Authority
BR
Brazil
Prior art keywords
cells
polynucleotide
methods
inducible promoter
central memory
Prior art date
Application number
BR112016023513A
Other languages
English (en)
Inventor
C Jensen Michael
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of BR112016023513A2 publication Critical patent/BR112016023513A2/pt

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    • C12N2820/00—Vectors comprising a special origin of replication system
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Abstract

a presente invenção proporciona ácidos nucleicos, vetores, células hospedeiras, métodos e composições para conferir e/ou aumentar as respostas imunes mediadas por imunoterapia celular, tais como por transferir adotivamente as células t de memória central cd8+ ou combinações de células t de memória central, com células t cd4+ que são geneticamente modificadas para expressar um receptor quimérico sob o controle de um promotor induzível. em algumas alternativas a célula hospedeira geneticamente modificada compreende um ácido nucleico compreendendo um polinucleotídeo que codifica para um receptor de antígeno quimérico que compreende um domínio de ligação ao ligante, um polinucleotídeo compreendendo uma região espaçadora, um polinucleotídeo compreendendo um domínio transmembranar, e um polinucleotídeo que compreende um domínio de sinalização intracelular sob o controle de um promotor induzível por fármacos. controlar a expressão do receptor quimérico prevê a capacidade de transformar a expressão on e off, dependendo do estado do paciente. as formulações farmacêuticas produzidas pelo método, e os métodos de utilização dos mesmos, também são descritos.
BR112016023513A 2014-04-10 2015-04-08 expressão de transgene relacionada com fármacos BR112016023513A2 (pt)

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US201462089730P 2014-12-09 2014-12-09
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