BR0207854A - Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido - Google Patents
Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbridoInfo
- Publication number
- BR0207854A BR0207854A BR0207854-6A BR0207854A BR0207854A BR 0207854 A BR0207854 A BR 0207854A BR 0207854 A BR0207854 A BR 0207854A BR 0207854 A BR0207854 A BR 0207854A
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- expression technology
- hybrid
- proteins containing
- antibody moiety
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"TECNOLOGIA DE EXPRESSãO PARA PROTEìNAS CONTENDO UMA PORçãO DE ANTICORPO DE ISOTIPO HìBRIDO". A presente invenção refere-se métodos e composições para eficientemente expressar as proteínas de fusão de anticorpo. As proteínas de fusão de anticorpo da invenção incluem uma porção de anticorpo híbrido contendo seq³ências de mais do que um tipo de anticorpo e/ou seq³ências de anticorpo mutantes. As proteínas de fusão de anticorpo híbrido da invenção podem ser produzidas em níveis elevados e podem combinar propriedades funcionais características de tipos de anticorpos diferentes além das propriedades funcionais de uma porção de não-anticorpo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27409601P | 2001-03-07 | 2001-03-07 | |
PCT/US2002/007011 WO2002072605A2 (en) | 2001-03-07 | 2002-03-07 | Expression technology for proteins containing a hybrid isotype antibody moiety |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207854A true BR0207854A (pt) | 2004-08-24 |
Family
ID=23046749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207854-6A BR0207854A (pt) | 2001-03-07 | 2002-03-07 | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
Country Status (17)
Country | Link |
---|---|
US (2) | US7148321B2 (pt) |
EP (1) | EP1366067B1 (pt) |
JP (1) | JP4234438B2 (pt) |
KR (2) | KR20090010127A (pt) |
CN (1) | CN1330664C (pt) |
AU (1) | AU2002248571B2 (pt) |
BR (1) | BR0207854A (pt) |
CA (1) | CA2440221C (pt) |
DK (1) | DK1366067T3 (pt) |
ES (1) | ES2393733T3 (pt) |
HU (1) | HUP0303428A2 (pt) |
MX (1) | MXPA03008031A (pt) |
PL (1) | PL206701B1 (pt) |
PT (1) | PT1366067E (pt) |
RU (1) | RU2003129528A (pt) |
WO (1) | WO2002072605A2 (pt) |
ZA (1) | ZA200307792B (pt) |
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2002
- 2002-03-07 PT PT02717581T patent/PT1366067E/pt unknown
- 2002-03-07 ES ES02717581T patent/ES2393733T3/es not_active Expired - Lifetime
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- 2002-03-07 RU RU2003129528/13A patent/RU2003129528A/ru unknown
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- 2002-03-07 JP JP2002571518A patent/JP4234438B2/ja not_active Expired - Fee Related
- 2002-03-07 DK DK02717581.9T patent/DK1366067T3/da active
- 2002-03-07 WO PCT/US2002/007011 patent/WO2002072605A2/en active Application Filing
- 2002-03-07 KR KR1020087032161A patent/KR20090010127A/ko not_active Application Discontinuation
- 2002-03-07 HU HU0303428A patent/HUP0303428A2/hu unknown
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- 2002-03-07 KR KR1020037011719A patent/KR100900176B1/ko not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
JP4234438B2 (ja) | 2009-03-04 |
KR20090010127A (ko) | 2009-01-28 |
ES2393733T3 (es) | 2012-12-27 |
CN1330664C (zh) | 2007-08-08 |
ZA200307792B (en) | 2004-07-06 |
KR100900176B1 (ko) | 2009-06-02 |
RU2003129528A (ru) | 2005-04-10 |
US8066994B2 (en) | 2011-11-29 |
CA2440221C (en) | 2013-02-05 |
CN1509293A (zh) | 2004-06-30 |
EP1366067B1 (en) | 2012-09-26 |
US7148321B2 (en) | 2006-12-12 |
US20030044423A1 (en) | 2003-03-06 |
EP1366067A2 (en) | 2003-12-03 |
EP1366067A4 (en) | 2005-07-20 |
US20060263856A1 (en) | 2006-11-23 |
WO2002072605A2 (en) | 2002-09-19 |
PL206701B1 (pl) | 2010-09-30 |
HUP0303428A2 (hu) | 2004-01-28 |
WO2002072605A3 (en) | 2002-11-14 |
MXPA03008031A (es) | 2003-12-04 |
KR20030092015A (ko) | 2003-12-03 |
AU2002248571B2 (en) | 2007-01-18 |
PT1366067E (pt) | 2012-11-29 |
CA2440221A1 (en) | 2002-09-19 |
DK1366067T3 (da) | 2012-10-22 |
PL366981A1 (en) | 2005-02-07 |
JP2004525630A (ja) | 2004-08-26 |
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