MX2022010807A - Productos de celulas t modificadas de genes de composicion definida. - Google Patents

Productos de celulas t modificadas de genes de composicion definida.

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Publication number
MX2022010807A
MX2022010807A MX2022010807A MX2022010807A MX2022010807A MX 2022010807 A MX2022010807 A MX 2022010807A MX 2022010807 A MX2022010807 A MX 2022010807A MX 2022010807 A MX2022010807 A MX 2022010807A MX 2022010807 A MX2022010807 A MX 2022010807A
Authority
MX
Mexico
Prior art keywords
cells
cell
isolated
genetically modified
cell products
Prior art date
Application number
MX2022010807A
Other languages
English (en)
Inventor
Michael C Jensen
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54288361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022010807(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of MX2022010807A publication Critical patent/MX2022010807A/es

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Abstract

Los aspectos de la invención descrita en la presente se refieren a planteamientos para producir células T genéticamente modificadas que comprenden un receptor de antígeno quimérico para terapia humana. En algunas alternativas, los métodos utilizan una selección y/o aislamiento de células T CD4+ y/o CD8+ de una población de células T mezcladas, tal como, células mononucleares de sangre periférica o derivas de aféresis. Una vez seleccionadas/aisladas, las células T CD4+ y/o CD8+ se activan entonces, se modifican genéticamente y se propagan, preferentemente, en cultivos separados o aislados en la presencia de una o más citocinas que soportan la supervivencia, injerto y/o proliferación de las células, así como, que promueven o inducen de forma preferente la retención de los receptores de superficie celular, tal como CD62L, CD28, y/o CD27. En la presente se incluyen también métodos de tratamiento, inhibición, mejora, o eliminación de un cáncer al administrar a un sujeto en necesidad de lo mismo, uno o más tipos de las células T genéticamente modificadas o composiciones que comprenden la célula T genéticamente modificada preparada como se describe en la presente.
MX2022010807A 2014-04-10 2016-10-06 Productos de celulas t modificadas de genes de composicion definida. MX2022010807A (es)

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MX2016013160A MX2016013160A (es) 2014-04-10 2015-04-08 Marcas geneticas de transgenes y metodos de uso.
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MX2016013160A MX2016013160A (es) 2014-04-10 2015-04-08 Marcas geneticas de transgenes y metodos de uso.
MX2016013144A MX2016013144A (es) 2014-04-10 2015-04-08 Metodo y composiciones para inmunoterapia celular.
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