MX2020005235A - Celula humana transformada y uso de la misma. - Google Patents

Celula humana transformada y uso de la misma.

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Publication number
MX2020005235A
MX2020005235A MX2020005235A MX2020005235A MX2020005235A MX 2020005235 A MX2020005235 A MX 2020005235A MX 2020005235 A MX2020005235 A MX 2020005235A MX 2020005235 A MX2020005235 A MX 2020005235A MX 2020005235 A MX2020005235 A MX 2020005235A
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MX
Mexico
Prior art keywords
cell
transformed
human cell
mhc
vivo
Prior art date
Application number
MX2020005235A
Other languages
English (en)
Inventor
Ok Jae Lim
Yun Jung Lee
Mun Kyung Kim
Jee Won Lee
Woo Seok Yang
Yu Young Kim
Young Eun Kwon
Seung Hyon Choe
Original Assignee
Mogam Inst Biomedical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mogam Inst Biomedical Res filed Critical Mogam Inst Biomedical Res
Publication of MX2020005235A publication Critical patent/MX2020005235A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2510/00—Genetically modified cells

Abstract

La presente invención se refiere a una célula humana transformada y al uso de la misma y, muy particularmente, a una célula transformada con un gen para codificar un receptor de membrana celular MHC I y un receptor de membrana celular MHC II usando un sistema de supresión de expresión génica usando un ARN guía, y el del mismo. Dicha célula transformada puede presentar efectivamente el efecto terapéutico de las células incluso in vivo, y no puede ser eliminada por una respuesta inmunitaria in vivo. Por lo tanto, se espera que una composición que comprende el inmunocito como ingrediente activo pueda usarse útilmente para el tratamiento de cáncer, enfermedades infecciosas, enfermedades degenerativas o enfermedades inmunológicas.
MX2020005235A 2017-11-16 2018-11-16 Celula humana transformada y uso de la misma. MX2020005235A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762587068P 2017-11-16 2017-11-16
PCT/KR2018/014112 WO2019098759A2 (ko) 2017-11-16 2018-11-16 형질전환된 인간세포 및 이의 용도

Publications (1)

Publication Number Publication Date
MX2020005235A true MX2020005235A (es) 2020-08-24

Family

ID=66537875

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005235A MX2020005235A (es) 2017-11-16 2018-11-16 Celula humana transformada y uso de la misma.

Country Status (11)

Country Link
US (1) US20200407713A1 (es)
EP (1) EP3712268A4 (es)
JP (1) JP2021503284A (es)
KR (1) KR20200074954A (es)
CN (1) CN111742049A (es)
AU (1) AU2018367792A1 (es)
CA (1) CA3082331A1 (es)
IL (1) IL274691A (es)
MX (1) MX2020005235A (es)
SG (1) SG11202004529XA (es)
WO (1) WO2019098759A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220005208A (ko) * 2020-07-06 2022-01-13 주식회사 지씨셀 면역원성이 감소된 신규한 이식용 세포
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144855A1 (en) 2020-12-31 2022-07-07 Crispr Therapeutics Ag Universal donor cells

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2910489A1 (en) * 2013-05-15 2014-11-20 Sangamo Biosciences, Inc. Methods and compositions for treatment of a genetic condition
KR101826904B1 (ko) * 2014-08-06 2018-02-08 기초과학연구원 조직적합성항원 유전자들의 교정을 통하여 구축한, 면역적합형 세포
EP3215623A4 (en) * 2014-11-06 2018-09-26 President and Fellows of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
CN108368520B (zh) * 2015-11-04 2023-01-17 菲特治疗公司 多能细胞的基因组工程改造
US20180362975A1 (en) * 2015-12-04 2018-12-20 Novartis Ag Compositions and methods for immunooncology
CN108699132B (zh) * 2015-12-18 2023-08-11 桑格摩生物治疗股份有限公司 Mhc细胞受体的靶向破坏
JP2019500043A (ja) * 2015-12-28 2019-01-10 ノバルティス アーゲー 異常ヘモグロビン症の治療用組成物および方法
WO2017143210A1 (en) * 2016-02-19 2017-08-24 The General Hospital Corporation Methods for generating universal and custom mhc/hla-compatible hematopoietic progenitor cells
AU2017226172B9 (en) * 2016-03-04 2023-08-24 Editas Medicine, Inc. CRISPR/Cpf1-related methods, compositions and components for cancer immunotherapy

Also Published As

Publication number Publication date
CA3082331A1 (en) 2019-05-23
CN111742049A (zh) 2020-10-02
JP2021503284A (ja) 2021-02-12
EP3712268A2 (en) 2020-09-23
AU2018367792A1 (en) 2020-06-11
WO2019098759A3 (ko) 2019-07-18
IL274691A (en) 2020-06-30
SG11202004529XA (en) 2020-06-29
EP3712268A4 (en) 2022-03-23
KR20200074954A (ko) 2020-06-25
WO2019098759A2 (ko) 2019-05-23
US20200407713A1 (en) 2020-12-31

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