EA201390194A1 - Улучшенный рекомбинантный фолликул-стимулирующий гормон человека - Google Patents

Улучшенный рекомбинантный фолликул-стимулирующий гормон человека

Info

Publication number
EA201390194A1
EA201390194A1 EA201390194A EA201390194A EA201390194A1 EA 201390194 A1 EA201390194 A1 EA 201390194A1 EA 201390194 A EA201390194 A EA 201390194A EA 201390194 A EA201390194 A EA 201390194A EA 201390194 A1 EA201390194 A1 EA 201390194A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fsh
improved recombinant
stimulating human
human hormone
recombinant follicle
Prior art date
Application number
EA201390194A
Other languages
English (en)
Other versions
EA029955B1 (ru
Inventor
Штеффен Голетц
Ларс Штекль
Original Assignee
Гликотоп Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43242604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390194(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Гликотоп Гмбх filed Critical Гликотоп Гмбх
Publication of EA201390194A1 publication Critical patent/EA201390194A1/ru
Publication of EA029955B1 publication Critical patent/EA029955B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к улучшенным препаратам FSH, которые способны в намного меньших концентрациях, чем обычно используемый FSH, получаемый из мочи, или рекомбинантный FSH, получаемый из клеток СНО, стимулировать выделение половых стероидов, которые действуют независимо от сигнализации цАМФ. Эти улучшенные препараты FSH могут быть использованы в лечении бесплодия.
EA201390194A 2010-08-04 2011-08-04 Препарат рекомбинантного фолликулстимулирующего гормона человека и его применение EA029955B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2010/004769 WO2012016576A1 (en) 2010-08-04 2010-08-04 Improved recombinant human follicle-stimulating hormone
PCT/EP2011/063492 WO2012017058A1 (en) 2010-08-04 2011-08-04 Improved recombinant human follicle-stimulating hormone

Publications (2)

Publication Number Publication Date
EA201390194A1 true EA201390194A1 (ru) 2013-06-28
EA029955B1 EA029955B1 (ru) 2018-06-29

Family

ID=43242604

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390194A EA029955B1 (ru) 2010-08-04 2011-08-04 Препарат рекомбинантного фолликулстимулирующего гормона человека и его применение

Country Status (27)

Country Link
US (1) US9527899B2 (ru)
EP (2) EP3075744B1 (ru)
JP (2) JP6001534B2 (ru)
KR (1) KR20130136448A (ru)
CN (2) CN103068839B (ru)
AR (1) AR082852A1 (ru)
AU (1) AU2011287525B2 (ru)
BR (1) BR112013004051A2 (ru)
CA (1) CA2805134C (ru)
CU (1) CU24043B1 (ru)
CY (1) CY1117778T1 (ru)
DK (1) DK2601210T3 (ru)
EA (1) EA029955B1 (ru)
ES (2) ES2764083T3 (ru)
HR (1) HRP20160671T1 (ru)
HU (1) HUE028357T2 (ru)
IL (1) IL223867B (ru)
MX (1) MX336489B (ru)
NZ (1) NZ604877A (ru)
PL (1) PL2601210T3 (ru)
PT (1) PT2601210T (ru)
RS (1) RS54905B1 (ru)
SG (1) SG186755A1 (ru)
SI (1) SI2601210T1 (ru)
SM (1) SMT201600219B (ru)
WO (2) WO2012016576A1 (ru)
ZA (1) ZA201209436B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI488640B (zh) * 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2013296709B2 (en) * 2012-07-30 2018-03-08 Trophogen Inc. Glycoprotein hormone long-acting superagonists
CN104543416B (zh) * 2013-10-09 2018-06-19 中国科学院大连化学物理研究所 一种调节雌性动物繁殖性能的功能性单糖饲料及其应用
CN103740754B (zh) * 2013-10-25 2015-06-24 中国食品药品检定研究院 含有鼠神经生长因子的表达载体及细胞
MX2016013449A (es) * 2014-04-18 2017-05-04 Glycotope Gmbh Hiperestimulacion ovarica controlada con la hormona estimuladora folicular humana recombinante mejorada.
EP3091033A1 (en) * 2015-05-06 2016-11-09 Gamamabs Pharma Anti-human-her3 antibodies and uses thereof
WO2017025566A1 (en) * 2015-08-10 2017-02-16 Glycotope Gmbh Improved recombinant factor vii
MX2018002921A (es) * 2015-09-17 2018-12-10 Glycotope Gmbh Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.
CN106053861A (zh) * 2016-07-28 2016-10-26 高常青 一种卵泡刺激素生物活性强度检测方法
CA3160345A1 (en) * 2019-11-06 2021-05-14 The Regents Of The University Of Colorado, A Body Corporate Modified follicle-stimulating hormone and methods of using the same
CN116063490A (zh) * 2021-09-07 2023-05-05 苏州晟济药业有限公司 一种vhh抗体或其抗原片段的突变体及其用途
WO2023215914A1 (en) * 2022-05-06 2023-11-09 The Regents Of The University Of Colorado, A Body Corporate Modified follicle-stimulating hormone and methods of using the same
WO2024100548A1 (en) * 2022-11-08 2024-05-16 Oncogreen Therapeutics S.A. Compound with anti-metastatic effect
WO2024100549A1 (en) * 2022-11-08 2024-05-16 Oncogreen Therapeutics S.A. Compounds for use in macrophage reprogramming

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2372714A1 (en) 1999-05-07 2000-11-16 Stephen Franks The use of luteinizing hormone in the induction of pauci-or unifolliculogenesis
AU2002340562B2 (en) * 2001-10-22 2008-10-23 Merck Serono Sa Compositions of FSH with high sialylation degree and their use for the preparation of medicaments
EP1725673A1 (en) * 2004-02-13 2006-11-29 Glycotope Gmbh Sialytated glycoproteins-process conditions and an efficient method for their production
BRPI0716997B8 (pt) 2006-09-10 2021-05-25 Glycotope Gmbh proteína ou composição de moléculas de proteína, métodos para produção e uso da mesma
GB2459641B (en) * 2008-04-16 2012-06-27 Ubiquisys Ltd Basestation power control
TWI488640B (zh) * 2008-04-16 2015-06-21 Ferring Int Ct Sa 藥學製劑
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
HRP20160671T1 (hr) 2016-09-23
EP3075744B1 (en) 2019-12-18
CN106146646A (zh) 2016-11-23
EP2601210B1 (en) 2016-05-11
US9527899B2 (en) 2016-12-27
CA2805134C (en) 2020-01-28
AR082852A1 (es) 2013-01-16
US20130137636A1 (en) 2013-05-30
AU2011287525A1 (en) 2013-01-17
JP2013535481A (ja) 2013-09-12
KR20130136448A (ko) 2013-12-12
JP2016168055A (ja) 2016-09-23
ZA201209436B (en) 2014-02-26
CN103068839A (zh) 2013-04-24
NZ604877A (en) 2014-09-26
PT2601210T (pt) 2016-07-07
WO2012017058A1 (en) 2012-02-09
SI2601210T1 (sl) 2016-09-30
MX336489B (es) 2016-01-21
RS54905B1 (sr) 2016-10-31
BR112013004051A2 (pt) 2016-07-05
JP6001534B2 (ja) 2016-10-05
EA029955B1 (ru) 2018-06-29
CU20130019A7 (es) 2013-05-31
SMT201600219B (it) 2016-08-31
WO2012017058A8 (en) 2016-04-07
PL2601210T3 (pl) 2016-11-30
EP3075744A1 (en) 2016-10-05
IL223867B (en) 2018-04-30
EP2601210A1 (en) 2013-06-12
ES2764083T3 (es) 2020-06-02
SG186755A1 (en) 2013-02-28
DK2601210T3 (en) 2016-07-04
WO2012016576A1 (en) 2012-02-09
ES2576868T3 (es) 2016-07-11
CY1117778T1 (el) 2017-05-17
CU24043B1 (es) 2014-11-27
MX2013000500A (es) 2013-02-21
CA2805134A1 (en) 2012-02-09
CN103068839B (zh) 2016-06-22
AU2011287525B2 (en) 2014-09-25
HUE028357T2 (en) 2016-12-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU