MX2018002921A - Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada. - Google Patents

Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.

Info

Publication number
MX2018002921A
MX2018002921A MX2018002921A MX2018002921A MX2018002921A MX 2018002921 A MX2018002921 A MX 2018002921A MX 2018002921 A MX2018002921 A MX 2018002921A MX 2018002921 A MX2018002921 A MX 2018002921A MX 2018002921 A MX2018002921 A MX 2018002921A
Authority
MX
Mexico
Prior art keywords
stimulating hormone
increased stability
hormone composition
follicle
mammalian follicle
Prior art date
Application number
MX2018002921A
Other languages
English (en)
Inventor
Stoeckl Lars
Goletz Steffen
Original Assignee
Glycotope Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycotope Gmbh filed Critical Glycotope Gmbh
Publication of MX2018002921A publication Critical patent/MX2018002921A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere al campo de gonadotropinas. En particular, se proporciona una composición mejorada que comprende hormona folículo-estimulante humana recombinante y clorocresol. Esta composición mejorada tiene una estabilidad incrementada a altas temperaturas y es útil en el tratamiento de infertilidad, en particular en pacientes humanos.
MX2018002921A 2015-09-17 2016-09-16 Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada. MX2018002921A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU92831 2015-09-17
PCT/EP2016/071917 WO2017046295A1 (en) 2015-09-17 2016-09-16 Mammalian follicle-stimulating hormone composition with increased stability

Publications (1)

Publication Number Publication Date
MX2018002921A true MX2018002921A (es) 2018-12-10

Family

ID=54256805

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018002921A MX2018002921A (es) 2015-09-17 2016-09-16 Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.

Country Status (12)

Country Link
US (1) US20180264086A1 (es)
EP (1) EP3349728A1 (es)
JP (1) JP7255050B2 (es)
KR (1) KR20180052128A (es)
CN (2) CN108348465B (es)
AU (1) AU2016323541A1 (es)
BR (1) BR112018003455A2 (es)
CA (1) CA2994044A1 (es)
EA (1) EA201890163A1 (es)
IL (1) IL257815A (es)
MX (1) MX2018002921A (es)
WO (1) WO2017046295A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018002921A (es) 2015-09-17 2018-12-10 Glycotope Gmbh Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.
CN109731097A (zh) * 2018-12-25 2019-05-10 长春圣金诺生物制药有限公司 一种rh-FSH制剂及其制备方法
KR102357795B1 (ko) * 2019-04-19 2022-02-04 한양대학교 산학협력단 포스파티딘산 함유 온도 감응성 조성물 및 이의 용도
KR20230133595A (ko) 2022-03-11 2023-09-19 한국한의약진흥원 등검은말벌독에 함유된 세로토닌의 안정성을 유지하기 위한 조성물
CN115429751B (zh) * 2022-09-21 2023-11-17 景泽生物医药(合肥)股份有限公司 一种人重组卵泡刺激素注射剂及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272135A (en) 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
JP4719357B2 (ja) * 1998-07-23 2011-07-06 アレス トレイディング ソシエテ アノニム Ｆｓｈ及びｆｓｈ変異体の製剤、製品及び方法
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
CN102821782B (zh) * 2010-02-12 2015-07-15 印塔斯生物制药有限公司 促卵泡激素的液体配制品
WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
WO2012168680A1 (en) * 2011-06-06 2012-12-13 Ferring B.V. Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
MX2018002921A (es) 2015-09-17 2018-12-10 Glycotope Gmbh Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.

Also Published As

Publication number Publication date
CN108348465B (zh) 2020-11-10
IL257815A (en) 2018-04-30
BR112018003455A2 (pt) 2018-09-25
AU2016323541A1 (en) 2018-04-12
KR20180052128A (ko) 2018-05-17
US20180264086A1 (en) 2018-09-20
EP3349728A1 (en) 2018-07-25
CA2994044A1 (en) 2017-03-23
JP7255050B2 (ja) 2023-04-11
JP2018528224A (ja) 2018-09-27
WO2017046295A1 (en) 2017-03-23
CN113198005A (zh) 2021-08-03
EA201890163A1 (ru) 2018-10-31
CN108348465A (zh) 2018-07-31

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