AR082852A1 - Hormona foliculoestimulante humana recombinante, composicion farmaceutica que la comprende y uso de la misma - Google Patents
Hormona foliculoestimulante humana recombinante, composicion farmaceutica que la comprende y uso de la mismaInfo
- Publication number
- AR082852A1 AR082852A1 ARP110102828A ARP110102828A AR082852A1 AR 082852 A1 AR082852 A1 AR 082852A1 AR P110102828 A ARP110102828 A AR P110102828A AR P110102828 A ARP110102828 A AR P110102828A AR 082852 A1 AR082852 A1 AR 082852A1
- Authority
- AR
- Argentina
- Prior art keywords
- stimulating hormone
- follicle stimulating
- human follicle
- relative amount
- foliculating
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 abstract 5
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 4
- 229920001503 Glucan Polymers 0.000 abstract 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 1
- 230000011496 cAMP-mediated signaling Effects 0.000 abstract 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 229950006780 n-acetylglucosamine Drugs 0.000 abstract 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pregnancy & Childbirth (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Preparaciones que comprenden una hormona foliculoestimulante humana mejorada que puede estimular la liberación de esteroides sexuales en una concentración mucho menor que la hormona foliculoestimulante humana de uso habitual, que es una hormona foliculoestimulante humana urinaria o una hormona foliculoestimulante humana recombinante que se obtiene de células CHO, y que actúa de manera independiente de la señalización del AMPc. Estas preparaciones que comprenden una hormona foliculoestimulante humana mejorada pueden usarse en el tratamiento de la infertilidad.Reivindicación 1: Una preparación de FSH recombinante, caracterizada porque la FSH recombinante en la preparación tiene un patrón de glucosilación que presenta una o más de las siguientes características: (i) una cantidad relativa de glucanos que presentan N-acetilglucosamina bisecada (bisGlcNAc) de al menos 20%; y/o (ii) una cantidad relativa de glucanos que presentan fucosa de al menos 30%; y/o (iii) una cantidad relativa de ácido siálico unido a través de enlaces 2,6 de al menos 30%; y/o (iv) una gran diversidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/004769 WO2012016576A1 (en) | 2010-08-04 | 2010-08-04 | Improved recombinant human follicle-stimulating hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082852A1 true AR082852A1 (es) | 2013-01-16 |
Family
ID=43242604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102828A AR082852A1 (es) | 2010-08-04 | 2011-08-04 | Hormona foliculoestimulante humana recombinante, composicion farmaceutica que la comprende y uso de la misma |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9527899B2 (es) |
| EP (2) | EP3075744B1 (es) |
| JP (2) | JP6001534B2 (es) |
| KR (1) | KR20130136448A (es) |
| CN (2) | CN106146646A (es) |
| AR (1) | AR082852A1 (es) |
| AU (1) | AU2011287525B2 (es) |
| BR (1) | BR112013004051A2 (es) |
| CA (1) | CA2805134C (es) |
| CU (1) | CU24043B1 (es) |
| CY (1) | CY1117778T1 (es) |
| DK (1) | DK2601210T3 (es) |
| EA (1) | EA029955B1 (es) |
| ES (2) | ES2576868T3 (es) |
| HR (1) | HRP20160671T1 (es) |
| HU (1) | HUE028357T2 (es) |
| IL (1) | IL223867B (es) |
| MX (1) | MX336489B (es) |
| NZ (1) | NZ604877A (es) |
| PL (1) | PL2601210T3 (es) |
| PT (1) | PT2601210T (es) |
| RS (1) | RS54905B1 (es) |
| SG (1) | SG186755A1 (es) |
| SI (1) | SI2601210T1 (es) |
| SM (1) | SMT201600219B (es) |
| WO (2) | WO2012016576A1 (es) |
| ZA (1) | ZA201209436B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| AR090095A1 (es) | 2011-06-06 | 2014-10-22 | Ferring Bv | Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| CN112409472A (zh) * | 2012-07-30 | 2021-02-26 | 特洛佛根股份有限公司 | 糖蛋白激素长效超激动剂 |
| CN104543416B (zh) * | 2013-10-09 | 2018-06-19 | 中国科学院大连化学物理研究所 | 一种调节雌性动物繁殖性能的功能性单糖饲料及其应用 |
| CN103740754B (zh) * | 2013-10-25 | 2015-06-24 | 中国食品药品检定研究院 | 含有鼠神经生长因子的表达载体及细胞 |
| US20170035854A1 (en) | 2014-04-18 | 2017-02-09 | Glycotope Gmbh | Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone |
| EP3091033A1 (en) * | 2015-05-06 | 2016-11-09 | Gamamabs Pharma | Anti-human-her3 antibodies and uses thereof |
| WO2017025566A1 (en) * | 2015-08-10 | 2017-02-16 | Glycotope Gmbh | Improved recombinant factor vii |
| CN113198005B (zh) | 2015-09-17 | 2024-09-06 | 广州汉腾生物科技有限公司 | 具有提高的稳定性的哺乳动物促卵泡激素组合物 |
| CN106053861A (zh) * | 2016-07-28 | 2016-10-26 | 高常青 | 一种卵泡刺激素生物活性强度检测方法 |
| EP4055038A4 (en) * | 2019-11-06 | 2023-11-15 | The Regents of the University of Colorado, a body corporate | MODIFIED FOLLICLE-STIMULATING HORMONE AND METHOD OF USE THEREOF |
| CN116375862A (zh) * | 2021-09-07 | 2023-07-04 | 苏州晟济药业有限公司 | 一种单域抗体或其抗原结合片段及其应用 |
| WO2023215914A1 (en) * | 2022-05-06 | 2023-11-09 | The Regents Of The University Of Colorado, A Body Corporate | Modified follicle-stimulating hormone and methods of using the same |
| WO2024100548A1 (en) * | 2022-11-08 | 2024-05-16 | Oncogreen Therapeutics S.A. | Compound with anti-metastatic effect |
| WO2024100549A1 (en) * | 2022-11-08 | 2024-05-16 | Oncogreen Therapeutics S.A. | Compounds for use in macrophage reprogramming |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60029318T3 (de) | 1999-05-07 | 2016-03-10 | Merck Serono Sa | Gonadotrophine |
| UA87433C2 (ru) * | 2001-10-22 | 2009-07-27 | Еплайд Рісьорч Системз Ерс Холдінг Н.В. | Гонадотропины для стимулирования фолликулогенеза |
| EP1725673A1 (en) * | 2004-02-13 | 2006-11-29 | Glycotope Gmbh | Sialytated glycoproteins-process conditions and an efficient method for their production |
| KR101603632B1 (ko) | 2006-09-10 | 2016-03-16 | 글리코토페 게엠베하 | 항체 발현을 위한 골수성 백혈병 기원의 인간 세포의 용도 |
| TWI488640B (zh) * | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| GB2459641B (en) * | 2008-04-16 | 2012-06-27 | Ubiquisys Ltd | Basestation power control |
| EP2325194A1 (en) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
-
2010
- 2010-08-04 WO PCT/EP2010/004769 patent/WO2012016576A1/en active Application Filing
-
2011
- 2011-08-04 SI SI201130854A patent/SI2601210T1/sl unknown
- 2011-08-04 SG SG2012093191A patent/SG186755A1/en unknown
- 2011-08-04 PL PL11757190.1T patent/PL2601210T3/pl unknown
- 2011-08-04 KR KR1020137005553A patent/KR20130136448A/ko not_active Application Discontinuation
- 2011-08-04 HU HUE11757190A patent/HUE028357T2/en unknown
- 2011-08-04 RS RS20160459A patent/RS54905B1/sr unknown
- 2011-08-04 CA CA2805134A patent/CA2805134C/en not_active Expired - Fee Related
- 2011-08-04 MX MX2013000500A patent/MX336489B/es unknown
- 2011-08-04 NZ NZ604877A patent/NZ604877A/en not_active IP Right Cessation
- 2011-08-04 ES ES11757190.1T patent/ES2576868T3/es active Active
- 2011-08-04 CN CN201610363950.XA patent/CN106146646A/zh active Pending
- 2011-08-04 CN CN201180037096.3A patent/CN103068839B/zh active Active
- 2011-08-04 AU AU2011287525A patent/AU2011287525B2/en not_active Ceased
- 2011-08-04 EP EP16168841.1A patent/EP3075744B1/en not_active Revoked
- 2011-08-04 BR BR112013004051A patent/BR112013004051A2/pt not_active Application Discontinuation
- 2011-08-04 WO PCT/EP2011/063492 patent/WO2012017058A1/en active Application Filing
- 2011-08-04 EA EA201390194A patent/EA029955B1/ru not_active IP Right Cessation
- 2011-08-04 PT PT117571901T patent/PT2601210T/pt unknown
- 2011-08-04 DK DK11757190.1T patent/DK2601210T3/en active
- 2011-08-04 ES ES16168841T patent/ES2764083T3/es active Active
- 2011-08-04 EP EP11757190.1A patent/EP2601210B1/en not_active Revoked
- 2011-08-04 AR ARP110102828A patent/AR082852A1/es unknown
- 2011-08-04 JP JP2013522259A patent/JP6001534B2/ja not_active Expired - Fee Related
- 2011-08-04 US US13/814,059 patent/US9527899B2/en active Active
-
2012
- 2012-12-12 ZA ZA2012/09436A patent/ZA201209436B/en unknown
- 2012-12-25 IL IL223867A patent/IL223867B/en active IP Right Grant
-
2013
- 2013-02-04 CU CU2013000019A patent/CU24043B1/es active IP Right Grant
-
2016
- 2016-06-13 HR HRP20160671TT patent/HRP20160671T1/hr unknown
- 2016-06-16 CY CY20161100539T patent/CY1117778T1/el unknown
- 2016-06-24 JP JP2016125181A patent/JP2016168055A/ja not_active Withdrawn
- 2016-07-06 SM SM201600219T patent/SMT201600219B/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |